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Effect of Danggui Niantongtang on Intestinal Flora of Knee Osteoarthritis Mice Based on 16S rDNA Sequencing
更新时间：2024-04-30
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    • Effect of Danggui Niantongtang on Intestinal Flora of Knee Osteoarthritis Mice Based on 16S rDNA Sequencing

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    • “一项关于当归拈痛汤治疗膝骨关节炎（KOA）机制的研究取得新进展。研究团队利用16S rDNA技术，深入探讨了当归拈痛汤调控肠道菌群对KOA的治疗作用。实验结果显示，高剂量当归拈痛汤能显著缓解KOA小鼠的疼痛症状，改善关节结构紊乱，维持膝关节软骨完整性，并调整肠道菌群物种丰富度与结构。通过对比假手术组、模型组及当归拈痛汤组，研究团队发现模型组中部分菌群丰度显著提高，而当归拈痛汤组则能显著降低这些菌群丰度，同时提升其他菌群丰度。这些发现表明，当归拈痛汤可能通过调节肠道菌群结构、促进益生菌生长、抑制有害致病菌，实现对KOA的有效治疗。这一研究成果不仅为KOA的治疗提供了新的思路，也为中药与肠道菌群相互作用的研究开辟了新方向。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 9-17(2024)

    • DOI：10.13422/j.cnki.syfjx.20232442    

      CLC： R2-0;R33;R289;R684.3

    • Published：05 June 2024，

      Published Online：01 February 2024，

      Received：10 October 2023，

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  • WU Shuang,YUAN Lixia,LIAO Qing,et al.Effect of Danggui Niantongtang on Intestinal Flora of Knee Osteoarthritis Mice Based on 16S rDNA Sequencing[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):9-17. DOI： 10.13422/j.cnki.syfjx.20232442.

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