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Mechanism of Linggui Zhugantang in Promoting Astrocyte Endocytosis and Degradation of Amyloid β
更新时间：2024-04-30
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    • Mechanism of Linggui Zhugantang in Promoting Astrocyte Endocytosis and Degradation of Amyloid β

    • “科研团队深入探讨了传统中药苓桂术甘汤（LGZGT）在阿尔茨海默病（AD）治疗中的潜力。研究通过构建β淀粉样蛋白1-42（Aβ1-42）诱导的大鼠原代星形胶质细胞（AS）AD模型，观察了LGZGT含药血清对该模型的影响。实验结果显示，Aβ1-42对AS的增殖具有抑制作用，而LGZGT含药血清能显著提高细胞存活率，降低乳酸脱氢酶（LDH）活力，减轻细胞损伤。此外，LGZGT还能上调Aβ相关降解酶如胰岛素降解酶（IDE）和组织蛋白酶D（CTSD）的表达，增强组织蛋白酶B（CTSB）的荧光强度，降低细胞内Aβ1-42含量。这一发现表明，LGZGT对Aβ1-42诱导的AS具有保护作用，并能促进Aβ的降解。其机制可能与减轻Aβ毒性、增强细胞活力、促进IDE、CTSD、CTSB的表达及恢复溶酶体的功能相关。这为AD的治疗提供了新的候选药物和研究方向。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 1-8(2024)

    • DOI：10.13422/j.cnki.syfjx.20232444    

      CLC： R2-0;R33;R289;R742

    • Published：05 June 2024，

      Published Online：02 February 2024，

      Received：28 November 2023，

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  • GAO Min,CHENG Xiaojing,TIAN Qingrong,et al.Mechanism of Linggui Zhugantang in Promoting Astrocyte Endocytosis and Degradation of Amyloid β[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):1-8. DOI： 10.13422/j.cnki.syfjx.20232444.

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