Effect of Astragalus Formula Diet Nutrition Support Combined with Piracetam on Yin Deficiency and Yang Hyperactivity Syndrome and Serum TRAIL，TGF-<italic style="font-style: italic">β</italic><sub>1</sub> in Patients with Hypertensive Cerebral Hemorrhage

WANG Guanglyu; PAN Mingyuan; DENG Feng; CHEN Kun; MO Yimin; YE Tengda

doi:10.13422/j.cnki.syfjx.20232499

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Effect of Astragalus Formula Diet Nutrition Support Combined with Piracetam on Yin Deficiency and Yang Hyperactivity Syndrome and Serum TRAIL，TGF-β₁ in Patients with Hypertensive Cerebral Hemorrhage

XXXX | 更新时间：2023-10-10

- Effect of Astragalus Formula Diet Nutrition Support Combined with Piracetam on Yin Deficiency and Yang Hyperactivity Syndrome and Serum TRAIL，TGF-β₁ in Patients with Hypertensive Cerebral Hemorrhage
- Chinese Journal of Experimental Traditional Medical Formulae Pages: 1-7(2023)
- 作者机构：
  
  北海市人民医院，广西北海 536000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20232499
  CLC： R242;R2-031;R287;R259;R619;R255.2
- Received：08 May 2023，
  
  Published Online：10 October 2023，
- 稿件说明：
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WANG Guanglyu, PAN Mingyuan, DENG Feng, et al. Effect of Astragalus Formula Diet Nutrition Support Combined with Piracetam on Yin Deficiency and Yang Hyperactivity Syndrome and Serum TRAIL，TGF-β₁ in Patients with Hypertensive Cerebral Hemorrhage[J/OL]. Chinese journal of experimental traditional medical formulae, 2023, 1-7.
DOI：

WANG Guanglyu, PAN Mingyuan, DENG Feng, et al. Effect of Astragalus Formula Diet Nutrition Support Combined with Piracetam on Yin Deficiency and Yang Hyperactivity Syndrome and Serum TRAIL，TGF-β₁ in Patients with Hypertensive Cerebral Hemorrhage[J/OL]. Chinese journal of experimental traditional medical formulae, 2023, 1-7. DOI： 10.13422/j.cnki.syfjx.20232499.

摘要

目的

评估黄芪配方膳营养支持联合吡拉西坦对高血压脑出血术后阴虚阳亢证疗效及血清肿瘤坏死因子相关凋亡诱导配体（TRAIL）、转化生长因子-

（TGF-

）的影响。

方法

纳入2021年6月至2022年12月期间北海市人民医院神经外科收治的70例接受定向软通道微创血肿引流术的高血压脑出血患者，采用随机数字表法将患者按1∶1分为对照组和观察组。对照组术后给予吡拉西坦，观察组在对照组的基础上给予黄芪配方膳营养支持，均治疗3周。分别于治疗前后采用美国国立卫生院卒中量表（NIHSS）评分量表评估患者神经功能缺损情况，采用Barthel指数量表评估患者日常生活能力。分别于治疗前后采集患者血清样本，采用硝酸盐还原酶法检测一氧化氮（NO）水平，采用放射免疫分析法检测内皮素-1（ET-1）水平，采用酶联免疫吸附法检测TRAIL、TGF-

水平，并比较两组患者中医证候积分及临床疗效。

结果

治疗后观察组总有效率为91.43%（32/35），高于对照组的71.43%（25/35），差异具有统计学意义（

=8.068，

0.05）。观察组患者术后苏醒时间短于对照组（

0.01），中医证候证积分改善优于对照组（

0.01）。与本组治疗前比较，治疗后两组患者NIHSS评分均显著降低、Barthel评分均显著升高（

0.01）；与对照组治疗后比较，观察组患者治疗后NIHSS评分显著降低、而Barthel评分显著升高（

0.01）。与本组治疗前比较，治疗后两组患者ET-1、TRAIL表达水平均显著降低（

0.01）；与对照组治疗后比较，观察组患者ET-1、TRAIL表达降低更显著（

0.01）。与本组治疗前比较，治疗后两组不安者NO和TGF-

的表达水平均显著升高（

0.01）；与对照组治疗后比较，观察组患者NO和TGF-

表达水平升高更显著（

0.01）。治疗期间，两组患者不良反应总发生率差异无统计学意义。

结论

黄芪配方膳营养支持联合吡拉西坦可有效改善高血压脑出血患者的阴虚阳亢证、神经功能缺损、日常生活能力及血管内皮功能损伤，且不增加不良反应发生率。

Abstract

Objective

Evaluate clinical effect of astragalus formula diet combined with piracetam on Yin deficiency and Yang hyperactivity after hypertensive cerebral hemorrhage and impact on expression of tumor necrosis factor related apoptosis inducing ligand （TRAIL） and transforming growth factor-

（TGF-

）.

Methods

Seventy patients with hypertensive intracerebral hemorrhage who underwent minimally invasive drainage of hematoma through a soft-channel were enrolled during June 2021 to December 2022，and 1∶1 randomly divided into control group and observation group. The control group was given piracetam after operation，while observation group was additionally given astragalus formula diet as nutritional support. Both groups were treated continuously for 3 weeks.the National Institutes of Health Stroke Scale （NIHSS） score scale was used to evaluate the neurological impairment of the patients before and after treatment，and the Barthel index scale was used to evaluate the daily living ability of the patients. Serum samples of the patients were collected before and after treatment and endothelin-1 （NO） levels were detected by nitrate reductase method，endothelin-1 （ET-1） levels were detected by radioimmunoassay，TRAIL and TGF-

levels were detected by enzyme-linked immunosorbent assay. Traditional Chinese medicine（TCM）syndrome score and clinical efficacy were compared between the two groups.

Result

After treatment，the total effective rate of the observation group was higher than that of the control group，the postoperative recovery time was shorter than that of the control group （

0.05），and the improvement of TCM syndrome score was better than that of the control group （

0.01）. Compared with before treatment，NIHSS was decreased and Barthel score was increased in both groups after treatment （

0.01）. Compared with control group，NIHSS score was lower and Barthel score was higher in observation group after treatment （

0.01）. Compared with before treatment，the expression levels of ET-1 and TRAIL in both groups were decreased after treatment，and compared with control group，the expression levels of ET-1 and TRAIL in observation group were decreased （

0.01）. Compared with before treatment，the expression levels of NO and TGF-

were increased after treatment，and compared with the control group，the expression levels of NO and TGF-

were increased in the observation group （

0.01）. During treatment，there was no difference in the total incidence of adverse reactions between the two groups.

Conclusion

Astragalus formula diet nutritional support combined with piracetam can effectively improve the syndrome，neurological deficit，daily living function and vascular endothelial function damage in patients with hypertensive cerebral hemorrhage，and does not increase the incidence of adverse reactions.

关键词

Keywords

references

ZHAO X H ， ZHANG S Z ， FENG J ， et al . Efficacy of neuroendoscopic surgery versus craniotomy for supratentorial hypertensive intracerebral hemorrhage：A meta-analysis of randomized controlled trials ［J］. Brain Behav ， 2019 ， 9 （ 12 ）： e01471 .

中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组 . 中国脑出血诊治指南（2019）［J］. 中华神经科杂志， 2019 ， 52 （ 12 ）： 994 - 1005 .

LI C X ， LI L ， ZHANG J F ， et al . Tripartite intensive intervention for prevention of rebleeding in elderly patients with hypertensive cerebral hemorrhage ［J］. World J Clin Cases ， 2021 ， 9 （ 33 ）： 10106 - 10115 .

TENG L ， CHEN W ， YIN C ， et al . Dexmedetomidine improves cerebral ischemia-reperfusion injury in rats via extracellular signal-regulated kinase/cyclic adenosine monophosphate response element binding protein signaling pathway ［J］. World Neurosurg ， 2019 ， 127 ： e624 - e630 .

中华中医药学会脑病分会，广东省中医药学会脑病专业委员会，广东省中西医结合学会卒中专业委员会 . 中西医结合脑卒中循证实践指南（2019）［J］. 中国循证医学杂志， 2020 ， 20 （ 8 ）： 901 - 912 .

CAO D ， LIU F ， LIU Q ， et al . Correlation analysis between TSP2，MMP-9 and perihematoma edema，as well as the short-term prognosis of patients with hypertensive intracerebral hemorrhage ［J］. Ann Palliat Med ， 2021 ， 10 （ 10 ）： 10930 - 10937 .

王丽颖，刘兴方，刘孟宇，等 . 高血压病中医诊疗指南释义［J］. 中华中医药杂志， 2015 ， 30 （ 10 ）： 3577 - 3579 .

ZHANG Y ， SONG L ， ZHAO J . Role of scalp hypothermia in patients undergoing minimally invasive evacuation of hypertensive cerebral hemorrhage ［J］. Pak J Med Sci ， 2019 ， 35 （ 5 ）： 1451 - 1455 .

SONG H ， MEN H ， SONG C ， et al . Low-molecular-weight heparin reduces the formation of lower limb deep venous thrombosis in patients with hypertensive intracerebral hemorrhage ［J］. Am J Transl Res ， 2021 ， 13 （ 9 ）： 10509 - 10516 .

李改，胡兵，张会敏 . 瘦素、IL-18、NLRP3与高血压性脑出血严重程度、预后的关系及其在预后评估中的价值［J］. 实用医学杂志， 2020 ， 36 （ 5 ）： 628 - 633 .

赵睿学，王停，朱佩轩，等 . 从厥阴“络”“风”角度探讨高血压［J］. 中国实验方剂学杂志， 2022 ， 28 （ 6 ）： 199 - 205

孟醒，熊兴江 . 《高血压中医诊疗专家共识》解读［J］. 中国实验方剂学杂志， 2022 ， 28 （ 11 ）： 192 - 205 .

WANG Y ， YAO W ， WANG L ， et al . The effect of butylphthalide injection on the cognitive function and the TLRs/NF- κ B pathway in hypertensive intracerebral hemorrhage ［J］. Am J Transl Res ， 2021 ， 13 （ 8 ）： 9578 - 9585 .

陈帅，韦姗姗，贾勇，等 . 代谢组学在高血压研究中的应用［J］. 中国实验方剂学杂志， 2020 ， 26 （ 2 ）： 210 - 217 .

李奕，李坤宁，姜春宁，等 . 中风先兆证的中医药疗法研究进展［J］. 中国中医急症， 2020 ， 29 （ 1 ）： 168 - 170，173 .

邢锡熙，吴绍钦，王益俊，等 . 高血压脑出血的中西医治疗进展［J］. 医学综述， 2020 ， 26 （ 5 ）： 997 - 1001 .

SALEHI N ， FIREK A ， MUNIR I . Pituitary apoplexy presenting as ophthalmoplegia and altered level of consciousness without headache ［J］. Case Rep Endocrinol ， 2018 ， 2018 ： 7124364 .

苏优拉，陈贵林 . 黄芪中黄酮类成分的研究进展［J］. 食品安全质量检测学报， 2021 ， 12 （ 3 ）： 849 - 857 .

SOEDA S ， KOZAKO T ， IWATA K ， et al . Oversulfated fucoidan inhibits the basic fibroblast growth factor-induced tube formation by human umbilical vein endothelial cells：Its possible mechanism of action ［J］. Biochim Biophys Acta ， 2000 ， 1497 （ 1 ）： 127 - 134 .

LIU J ， GAO D Y ， LI J N . Correlations of endothelin-1 gene polymorphisms and hypertensive intracerebral hemorrhage ［J］. Eur Rev Med Pharmacol Sci ， 2020 ， 24 （ 22 ）： 11776 - 11782 .

XIAO W ， JIANG Z ， WAN W ， et al . miR-145-5p targets MMP2 to protect brain injury in hypertensive intracerebral hemorrhage via inactivation of the Wnt/ β -catenin signaling pathway ［J］. Ann Transl Med ， 2022 ， 10 （ 10 ）： 571 .

TANG X ， WANG H ， CHEN H ， et al . Protective effects of astragalus membranaceus and ligustrazine on rat brain microvascular endothelial cell injury after oxygen-glucose deprivation/reoxygenation by suppressing the PKC δ /MARCKS pathway ［J］. Comb Chem High Throughput Screen ， 2021 ， 24 （ 7 ）： 947 - 956 .

BEYER K ， BAUKLOH A K ， STOYANOVA A ， et al . Interactions of tumor necrosis factor-related apoptosis-inducing ligand （TRAIL） with the immune system：Implications for inflammation and cancer ［J］. Cancers （Basel）， 2019 ， 11 （ 8 ）： 1161 .

ALTINTAS KADIRHAN O ， KUCUKDAGLI O T ， GULEN B . The effectiveness of serum S100B，TRAIL，and adropin levels in predicting clinical outcome，final infarct core，and stroke subtypes of acute ischemic stroke patients ［J］. Biomedica ， 2022 ，42（Sp. 1 ）： 55 - 63 .

WU D ， DENG S ， LI L ， et al . Correction：TGF- β 1 -mediated exosomal lnc-MMP2-2 increases blood-brain barrier permeability via the miRNA-1207-5p/EPB41L5 axis to promote non-small cell lung cancer brain metastasis ［J］. Cell Death Dis ， 2021 ， 12 （ 10 ）： 916 .

杨晓光，王朝林，张旭，等 . 血清IL-6、TRAIL在高血压脑出血患者中的表达及意义［J］. 疑难病杂志， 2017 ， 16 （ 6 ）： 554 - 557 .

张峰，李燕，李伟华 . 黄芪总黄酮对肝硬化大鼠肝组织病理、代谢指标及NF- κ B表达的影响［J］. 解剖学杂志， 2022 ， 45 （ 6 ）： 526 - 531 .

QIN Z ， CHEN L ， LIU M ， et al . Hesperidin reduces adverse symptomatic intracerebral hemorrhage by promoting TGF- β 1 for treating ischemic stroke using tissue plasminogen activator ［J］. Neurol Sci ， 2020 ， 41 （ 1 ）： 139 - 147 .

HSIEH H L ， LIU S H ， CHEN Y L ， et al . Astragaloside IV suppresses inflammatory response via suppression of NF- κ B，and MAPK signalling in human bronchial epithelial cells ［J］. Arch Physiol Biochem ， 2022 ， 128 （ 3 ）： 757 - 766 .

BAMODU O A ， KUO K T ， WANG C H ， et al . Astragalus polysaccharides （PG 2 ） enhances the M1 polarization of macrophages，functional maturation of dendritic cells，and T cell-mediated anticancer immune responses in patients with lung cancer ［J］. Nutrients ， 2019 ， 11 （ 10 ）： 2264 .

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Effect of Astragalus Formula Diet Nutrition Support Combined with Piracetam on Yin Deficiency and Yang Hyperactivity Syndrome and Serum TRAIL，TGF-β1 in Patients with Hypertensive Cerebral Hemorrhage

DOI：10.13422/j.cnki.syfjx.20232499

摘要

Abstract

关键词

Keywords

references

Effect of Astragalus Formula Diet Nutrition Support Combined with Piracetam on Yin Deficiency and Yang Hyperactivity Syndrome and Serum TRAIL，TGF-β₁ in Patients with Hypertensive Cerebral Hemorrhage