Effect of Modified Shenhong Tongluo Prescription on Cell Apoptosis in Rats with Myocardial Ischemia-reperfusion Injury by Bcl-2/Bax/Caspase-3 Signaling Pathway
|更新时间:2024-04-30
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Effect of Modified Shenhong Tongluo Prescription on Cell Apoptosis in Rats with Myocardial Ischemia-reperfusion Injury by Bcl-2/Bax/Caspase-3 Signaling Pathway
“An important progress has been made in the study of the mechanism of the effect of modified Shenhong Tongluo Formula on cell apoptosis in rats with myocardial ischemia-reperfusion injury. The research team successfully prepared a rat model of myocardial ischemia-reperfusion injury through carefully designed experiments, and observed the effect of modified Shenhong Tongluo Formula on myocardial cell apoptosis in the model rats. The experimental results showed that the modified Shenhong Tongluo Formula can significantly reduce the levels of creatine kinase isoenzyme, interleukin-6, and tumor necrosis factor - α in serum, while reducing the apoptosis rate of myocardial cells. In terms of protein expression, the modified Shenhong Tongluo Formula significantly downregulated the expression of apoptosis related proteins Bax and Caspase-3, while promoting the expression of anti apoptotic protein Bcl-2. This discovery indicates that the modified Shenhong Tongluo Formula has a protective effect on myocardial ischemia-reperfusion injury, and its mechanism may be related to inhibiting cell apoptosis and regulating the expression of apoptosis related proteins. This study not only provides experimental evidence for further exploring the pharmacological effects of Shenhong Tongluo Formula, but also provides new ideas and methods for the treatment of myocardial ischemia-reperfusion injury. In the future, the research team will continue to delve into the specific mechanism of action of Shenhong Tongluo Formula, in order to provide more effective drug choices for the prevention and treatment of related diseases.”
Chinese Journal of Experimental Traditional Medical FormulaeVol. 30, Issue 11, Pages: 104-110(2024)
LAI Yingrong,ZHAO Qianlin,JIANG Lihong.Effect of Modified Shenhong Tongluo Prescription on Cell Apoptosis in Rats with Myocardial Ischemia-reperfusion Injury by Bcl-2/Bax/Caspase-3 Signaling Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):104-110.
LAI Yingrong,ZHAO Qianlin,JIANG Lihong.Effect of Modified Shenhong Tongluo Prescription on Cell Apoptosis in Rats with Myocardial Ischemia-reperfusion Injury by Bcl-2/Bax/Caspase-3 Signaling Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):104-110. DOI: 10.13422/j.cnki.syfjx.20240211.
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HAO Wei
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