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Effect of Modified Shenhong Tongluo Prescription on Cell Apoptosis in Rats with Myocardial Ischemia-reperfusion Injury by Bcl-2/Bax/Caspase-3 Signaling Pathway
更新时间：2024-04-30
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    • Effect of Modified Shenhong Tongluo Prescription on Cell Apoptosis in Rats with Myocardial Ischemia-reperfusion Injury by Bcl-2/Bax/Caspase-3 Signaling Pathway

    • “一项关于参红通络方加减对心肌缺血再灌注损伤大鼠细胞凋亡作用机制的研究取得重要进展。研究团队通过精心设计的实验，成功制备了心肌缺血再灌注损伤大鼠模型，并观察了参红通络方加减对模型大鼠心肌细胞凋亡的影响。实验结果显示，参红通络方加减能显著降低血清中肌酸激酶同工酶、白细胞介素-6和肿瘤坏死因子-α的水平，同时减少心肌细胞的凋亡率。在蛋白表达方面，参红通络方加减明显下调了凋亡相关蛋白Bax和Caspase-3的表达，而促进了抗凋亡蛋白Bcl-2的表达。这一发现表明，参红通络方加减对心肌缺血再灌注损伤具有保护作用，其机制可能与抑制细胞凋亡、调节凋亡相关蛋白的表达有关。这项研究不仅为深入探索参红通络方的药理作用提供了实验依据，也为心肌缺血再灌注损伤的治疗提供了新的思路和方法。未来，研究团队将继续深入研究参红通络方的具体作用机制，以期为相关疾病的防治提供更为有效的药物选择。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 104-110(2024)

    • DOI：10.13422/j.cnki.syfjx.20240211    

      CLC： R284;R285;R289;R287;R22;R2-031;R33;R24

    • Published：05 June 2024，

      Published Online：22 January 2024，

      Received：06 December 2023，

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  • LAI Yingrong,ZHAO Qianlin,JIANG Lihong.Effect of Modified Shenhong Tongluo Prescription on Cell Apoptosis in Rats with Myocardial Ischemia-reperfusion Injury by Bcl-2/Bax/Caspase-3 Signaling Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):104-110. DOI： 10.13422/j.cnki.syfjx.20240211.

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