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Mechanism of Xiezhuo Jiedu Recipe Regulating Ferroptosis in Treatment of Ulcerative Colitis Based on Bioinformatics and Animal Experiments
更新时间：2024-04-30
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    • Mechanism of Xiezhuo Jiedu Recipe Regulating Ferroptosis in Treatment of Ulcerative Colitis Based on Bioinformatics and Animal Experiments

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    • “一项关于溃疡性结肠炎（UC）治疗的生物信息学研究取得了重要进展。研究人员运用生物信息学方法，成功筛选出与UC密切相关的铁死亡差异基因（FRGs），并验证了传统中药泄浊解毒方在治疗UC中的作用机制与调控细胞铁死亡相关。研究团队首先从GEO数据库中获取UC患者结肠黏膜组织的差异表达基因，与铁死亡基因进行交集分析，筛选出21个FRGs。经过聚类分析、LASSO回归和ROC曲线分析，确定了FBXW7、ZFP36、SLC7A11、TLR4为核心FRGs。动物实验进一步证实，这些核心FRGs与UC小鼠结肠黏膜中的免疫细胞浸润存在显著相关性。实验结果显示，模型组小鼠结肠黏膜组织结构紊乱，炎性细胞浸润严重。然而，经过泄浊解毒方及美沙拉嗪治疗后，小鼠结肠黏膜组织的炎症反应得到了不同程度的缓解。值得一提的是，泄浊解毒方高剂量组小鼠的结肠黏膜几乎无炎症改变。此外，与正常组相比，模型组小鼠结肠黏膜中FBXW7、ZFP36、SLC7A11、TLR4蛋白和mRNA的表达量显著升高。但经过泄浊解毒方及美沙拉嗪治疗后，这些核心FRGs的表达均显著下调。这一研究成果为UC的治疗提供了新的视角和解决方案，也为传统中药泄浊解毒方的临床应用提供了科学依据。未来，研究团队将继续深入探索这一作用机制的细节，以期为UC患者带来更有效的治疗方法。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 166-173(2024)

    • DOI：10.13422/j.cnki.syfjx.20240218    

      CLC： R284;R285;R289;R287;R22;R2-031;R33;R24

    • Published：05 June 2024，

      Published Online：05 February 2024，

      Received：02 January 2024，

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  • SUN Chaodi,LIU Jianping,DU Mingmin,et al.Mechanism of Xiezhuo Jiedu Recipe Regulating Ferroptosis in Treatment of Ulcerative Colitis Based on Bioinformatics and Animal Experiments[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):166-173. DOI： 10.13422/j.cnki.syfjx.20240218.

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