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Huaiqihuang Granules Affect Differentiation of Th17 Cells in IgA Vasculitis Nephritis Mice by Regulating AMPK/ACC Pathway
更新时间：2024-04-30
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    • Huaiqihuang Granules Affect Differentiation of Th17 Cells in IgA Vasculitis Nephritis Mice by Regulating AMPK/ACC Pathway

    • “一项关于槐杞黄颗粒对免疫球蛋白A血管炎肾炎小鼠干预作用的研究取得了重要进展。研究团队通过建立小鼠模型，观察了槐杞黄颗粒对IgAVN小鼠的治疗效果，并深入探讨了其疗效机制。研究结果显示，槐杞黄颗粒显著降低了小鼠的尿蛋白定量、尿β2-微球蛋白和血清白细胞介素-17等指标，同时还改善了肾脏IgA沉积和脾脏组织中的Th17细胞比例。这些结果表明，槐杞黄颗粒对IgAVN小鼠具有显著的治疗作用。进一步的研究发现，槐杞黄颗粒能够调控AMPK/ACC通路，影响Th17细胞的分化，从而纠正免疫炎症紊乱。这一发现为槐杞黄颗粒治疗IgAVN的机制提供了重要理论依据。综上所述，这项研究不仅为IgAVN的治疗提供了新的候选药物，也为深入探索槐杞黄颗粒的药理作用奠定了基础。未来，有望为更多免疫性疾病的治疗提供新的思路和方法。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 78-86(2024)

    • DOI：10.13422/j.cnki.syfjx.20240409    

      CLC： R2-0;R22;R285.5;R289;R33

    • Published：05 June 2024，

      Published Online：15 April 2024，

      Received：24 January 2024，

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  • YE Xinglan,LI Keying,LI Jiaxuan,et al.Huaiqihuang Granules Affect Differentiation of Th17 Cells in IgA Vasculitis Nephritis Mice by Regulating AMPK/ACC Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):78-86. DOI： 10.13422/j.cnki.syfjx.20240409.

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