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Microbial-lipid Metabolism Mechanism of Liver Injury in Wistar Rats Caused by Dictamni Cortex- Flavescens Sophora
更新时间：2024-04-30
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    • Microbial-lipid Metabolism Mechanism of Liver Injury in Wistar Rats Caused by Dictamni Cortex- Flavescens Sophora

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    • “一项关于白鲜皮-苦参对Wistar大鼠肝损伤后微生物变化的研究取得了重要进展。该研究利用高通量测序技术，深入探讨了白鲜皮-苦参致肝损伤的潜在微生物机制。研究团队通过给大鼠灌胃不同剂量的白鲜皮-苦参，观察了其对大鼠肝脏的影响。结果显示，中药中、高剂量组的大鼠肝脏重量和肝脏体质量比显著增加，且血清白蛋白、胆固醇水平也有所上升。此外，肝脏组织病理学出现了微小空泡样改变，表明白鲜皮-苦参可能对大鼠肝脏造成了损伤。值得一提的是，研究还发现白鲜皮-苦参给药后出现了明显的肠道菌群紊乱。与正常组相比，中药中、高剂量组的α多样性增加，物种组成也发生了显著变化。例如，厚壁菌门/拟杆菌门比例下降，而某些与脂代谢相关的微生物如Parasutterella、Romboutsia等则显著升高。相关性分析进一步表明，这些微生物的变化与血清胆固醇、肝脏体质量比等指标密切相关。这一研究成果为理解白鲜皮-苦参致肝损伤的微生物机制提供了新的视角，也为未来相关药物研发和临床应用提供了重要参考。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 34-42(2024)

    • DOI：10.13422/j.cnki.syfjx.20240424    

      CLC： R2-0;R22;R242;R285.5;R856.2

    • Published：05 June 2024，

      Published Online：08 January 2024，

      Received：29 October 2023，

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  • NIU Luna,WANG Chunguo,JING Lu.Microbial-lipid Metabolism Mechanism of Liver Injury in Wistar Rats Caused by Dictamni Cortex- Flavescens Sophora[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):34-42. DOI： 10.13422/j.cnki.syfjx.20240424.

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