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Protective Effect and Mechanism of Mori Folium Extract on Kidney of db/db Diabetic Mice
更新时间：2024-04-30
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    • Protective Effect and Mechanism of Mori Folium Extract on Kidney of db/db Diabetic Mice

    • “关于桑叶水提物对糖尿病小鼠肾脏保护作用的研究取得了新进展。研究团队通过精心设计的实验，发现桑叶水提物能够显著改善db/db糖尿病小鼠的肾脏结构和功能。这一发现为糖尿病肾病的防治提供了新的潜在药物选择。实验过程中，研究团队将小鼠分为不同组别，并给予不同药物处理。通过对比各组小鼠的生理指标和肾脏组织病理变化，他们发现桑叶水提物能够显著降低小鼠的血糖水平，改善肾脏功能，并减轻肾脏组织中的炎症反应。这些效果在给予高剂量桑叶水提物的小鼠中尤为明显。此外，研究团队还深入探讨了桑叶水提物发挥保护作用的机制。他们发现，桑叶水提物能够抑制Toll样受体4（TLR4）/髓样分化因子88（MyD88）/核转录因子-κB p65（NF-κB p65）信号通路的激活，从而减轻肾脏组织中的炎症反应和损伤。这一发现为我们理解桑叶水提物保护肾脏的机制提供了重要线索。综上所述，这项研究不仅揭示了桑叶水提物对糖尿病小鼠肾脏的保护作用，还为我们提供了关于其保护机制的深入认识。这一成果为糖尿病肾病的防治提供了新的思路和方法，有望为未来的药物研发和治疗策略提供有力支持。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 51-59(2024)

    • DOI：10.13422/j.cnki.syfjx.20240425    

      CLC： R2-0;R22;R242;R285.5;R856.2

    • Published：05 June 2024，

      Published Online：08 January 2024，

      Received：23 October 2023，

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  • HUANG Yan,ZHANG Huilin,HE Changhao,et al.Protective Effect and Mechanism of Mori Folium Extract on Kidney of db/db Diabetic Mice[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):51-59. DOI： 10.13422/j.cnki.syfjx.20240425.

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