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Analysis on Metabolites and Metabolic Pathways of Harmine in Rats by UPLC-Q-TOF-MS
更新时间：2024-04-30
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    • Analysis on Metabolites and Metabolic Pathways of Harmine in Rats by UPLC-Q-TOF-MS

    • “一项关于去氢骆驼蓬碱在大鼠体内代谢过程的研究取得了重要进展。通过采用超高效液相色谱-四极杆-飞行时间质谱法（UPLC-Q-TOF-MS），研究团队成功鉴定了去氢骆驼蓬碱在大鼠体内的代谢产物，并深入探讨了其在体内的分布差异及代谢途径。研究团队给SD大鼠单剂量灌胃去氢骆驼蓬碱后，收集了血浆、胆汁、尿液和粪便样品，并运用UPLC-Q-TOF-MS进行了详细分析。通过比对文献数据，他们共鉴定出42个代谢产物，其中血浆中26个，胆汁中17个，尿液中26个，粪便中13个。这些代谢产物涉及单羟基化、双羟基化、去甲基化、葡萄糖醛酸化及硫酸化等多种代谢途径。研究结果表明，去氢骆驼蓬碱在大鼠体内经历了Ⅰ相和Ⅱ相代谢反应，且原型药物在体内代谢较快。代谢产物主要通过肾脏排泄，这对于理解去氢骆驼蓬碱的药效学和物质基础研究具有重要意义。此项研究的成果不仅为去氢骆驼蓬碱的药效学和物质基础研究提供了重要参考，同时也为相关领域的深入研究开辟了新方向。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 202-209(2024)

    • DOI：10.13422/j.cnki.syfjx.20240464    

      CLC： R22;R969.1;R28;O657

    • Published：05 June 2024，

      Published Online：14 December 2023，

      Received：23 August 2023，

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  • CARTIERA Kurban,WANG Changhong,XU Nan,et al.Analysis on Metabolites and Metabolic Pathways of Harmine in Rats by UPLC-Q-TOF-MS[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):202-209. DOI： 10.13422/j.cnki.syfjx.20240464.

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LI Xuemin
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