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Gastrodin Inhibits Non-alcoholic Fatty Liver Disease via Mediating SREBP1c Signaling Pathway
更新时间：2024-04-30
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    • Gastrodin Inhibits Non-alcoholic Fatty Liver Disease via Mediating SREBP1c Signaling Pathway

    • “本研究深入探索了天麻素在治疗非酒精性脂肪肝（NAFLD）中的作用机制，为这一领域的研究注入了新的活力。研究者利用高脂高胆固醇饲料（HFHC）诱导的小鼠模型以及Huh7细胞模型，模拟了NAFLD的病理环境，并观察了天麻素对小鼠和细胞模型中脂质代谢的影响。研究发现，天麻素能够显著降低小鼠血清中的总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平，明显改善脂肪肝病变，降低肝脏内的脂质含量。同时，在体外实验中，天麻素也显著降低了Huh7细胞的脂质蓄积水平。这些结果均表明，天麻素在降低肝内脂质积累和血脂水平方面具有显著效果。进一步的机制研究表明，天麻素的作用可能与调节类固醇调节元件结合蛋白1c（SREBP1c）信号通路有关。该通路在脂质合成过程中发挥着关键作用，而天麻素能够显著降低小鼠和Huh7细胞中SREBP1c及其下游脂质合成相关基因的表达水平，从而抑制脂质合成。这一发现为理解天麻素治疗NAFLD的作用机制提供了新的视角。综上所述，本研究的结果揭示了天麻素在降低肝内脂质积累和血脂水平、改善NAFLD方面的潜力，并初步阐明了其作用机制。这一发现为NAFLD的治疗提供了新的候选药物和研究方向，有望为这一领域的发展带来新的突破。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 70-77(2024)

    • DOI：10.13422/j.cnki.syfjx.20240504    

      CLC： R2-0;R22;R285.5;R289;R33

    • Published：05 June 2024，

      Published Online：29 March 2024，

      Received：14 January 2024，

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  • ZHANG Menglian,ZHANG Yaowen,TANG Linfeng,et al.Gastrodin Inhibits Non-alcoholic Fatty Liver Disease via Mediating SREBP1c Signaling Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):70-77. DOI： 10.13422/j.cnki.syfjx.20240504.

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