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Mechanism of Modified Tianwang Buxindan on Skin of Sleep-deprived Mice Through PI3K/Akt/Nrf2 Signaling Pathway
更新时间：2024-04-30
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    • Mechanism of Modified Tianwang Buxindan on Skin of Sleep-deprived Mice Through PI3K/Akt/Nrf2 Signaling Pathway

    • “有关天王补心丹加减（MTBD）对睡眠剥夺（SD）小鼠皮肤作用的研究取得了新进展。研究通过观察SD小鼠皮肤的变化，深入探讨了MTBD改善皮肤老化的作用机制。实验中，研究人员将小鼠分为不同组别，模拟SD状态并施加不同剂量的MTBD治疗。结果显示，SD导致小鼠出现体重减轻、精神萎靡、毛色晦暗等衰老迹象，同时皮肤组织也发生了一系列病理变化，包括皮肤变薄、胶原纤维减少等。而MTBD治疗则能有效改善这些症状，提高皮肤含水率、羟脯氨酸含量和超氧化物歧化酶活性，降低丙二醛含量和炎症因子水平。更重要的是，研究还发现MTBD的作用机制与激活PI3K/Akt/Nrf2信号通路相关。这一发现为MTBD改善皮肤老化的作用提供了新的解释，也为今后的研究提供了新的方向。总之，该研究为深入理解睡眠剥夺对皮肤的影响以及寻找有效的改善方法提供了重要依据，也为中药在皮肤保健领域的应用提供了新的思路。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 120-128(2024)

    • DOI：10.13422/j.cnki.syfjx.20240505    

      CLC： R2-0;R22;R285.5;R289;R33

    • Published：05 June 2024，

      Published Online：11 April 2024，

      Received：17 February 2024，

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  • CHEN Juanping,PENG Yuan,HONG Xuemin,et al.Mechanism of Modified Tianwang Buxindan on Skin of Sleep-deprived Mice Through PI3K/Akt/Nrf2 Signaling Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):120-128. DOI： 10.13422/j.cnki.syfjx.20240505.

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