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Effect and Mechanism of Sishenjian on Synovial Lesions in Knee Osteoarthritis Rats
更新时间：2024-04-30
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    • Effect and Mechanism of Sishenjian on Synovial Lesions in Knee Osteoarthritis Rats

    • “四神煎对碘乙酸钠诱导的大鼠膝骨关节炎（KOA）滑膜病变的影响及机制得到了深入研究。研究人员采用了60只雌性SD大鼠，通过关节腔内注射碘乙酸钠复制KOA大鼠模型，并分别给予塞来昔布和四神煎进行干预。经过连续4周的实验，研究人员发现，与模型组相比，四神煎各剂量组大鼠膝关节横径显著减小，膝关节滑液中的炎性细胞因子IL-1β和TNF-α表达水平也显著降低。此外，四神煎还能明显降低膝关节滑膜中TGF-β1/Smad2/3通路相关蛋白和mRNA的表达，从而抑制滑膜纤维化和血管新生。这一研究不仅为KOA滑膜病变的治疗提供了新的药物候选，同时也为深入探索KOA的发病机制和治疗方法提供了有益的参考。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 18-26(2024)

    • DOI：10.13422/j.cnki.syfjx.20240506    

      CLC： R2-0;R22;R285.5;R289;R33

    • Published：05 June 2024，

      Published Online：03 April 2024，

      Received：19 February 2024，

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  • HU Zixuan,HUANG Xuejun,YAO Nan,et al.Effect and Mechanism of Sishenjian on Synovial Lesions in Knee Osteoarthritis Rats[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):18-26. DOI： 10.13422/j.cnki.syfjx.20240506.

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