“Significant progress has been made in the research of anti-inflammatory active ingredients in honeysuckle and mountain silver flowers. Inflammation is a key driving factor for various diseases, and finding anti-inflammatory drugs is crucial. Honeysuckle and honeysuckle, as traditional Chinese medicines for clearing heat and detoxifying, have significant medicinal value. This study analyzed the differences in anti-inflammatory active ingredients between honeysuckle and mountain silver flower, and summarized their mechanisms of action. Honeysuckle and honeysuckle exert anti-inflammatory effects by affecting the release of inflammatory cytokines, regulating inflammatory signaling pathways such as NF - κ B, MAPK, STAT3, enhancing antioxidant stress resistance, immune defense, and improving intestinal microbiota. This study provides a theoretical basis for the clinical application of both in the field of medicine, demonstrating their enormous potential for development.”