您当前的位置：
首页 >
文章列表页 >
Effect of Shenfu Yixin Granules on Mitochondrial Dynamics in Rats with Heart Failure After Myocardial Infarction
更新时间：2024-04-30
|

    • Effect of Shenfu Yixin Granules on Mitochondrial Dynamics in Rats with Heart Failure After Myocardial Infarction

    • “一项关于参附益心颗粒对心肌梗死后心力衰竭大鼠线粒体动力学影响的研究取得重要进展。该研究采用左冠状动脉前降支结扎术制备了心力衰竭大鼠模型，并通过多种实验手段深入探讨了参附益心颗粒的作用机制。实验结果显示，与假手术组相比，模型组大鼠的心功能参数明显降低，血清脑钠肽和可溶性生长刺激表达基因2蛋白含量显著增加，同时心肌细胞出现排列紊乱、炎性细胞浸润和心肌纤维化等病理改变。这些结果表明，心力衰竭大鼠模型制备成功。值得注意的是，与模型组相比，参附益心颗粒高剂量组和沙库巴曲缬沙坦钠组大鼠的心功能参数得到明显改善，血清脑钠肽和可溶性生长刺激表达基因2蛋白含量显著降低，心肌细胞的病理改变也有所缓解。此外，这两个药物组大鼠的线粒体融合蛋白和视神经萎缩蛋白的表达水平也明显升高，而动力相关蛋白和分裂蛋白的表达水平则降低。这些结果表明，参附益心颗粒能够抗心力衰竭，改善心功能，其机制可能与调整线粒体动力学相关。该研究为心力衰竭的治疗提供了新的思路和方法，具有重要的临床意义。未来，我们将继续深入研究参附益心颗粒的作用机制，为心力衰竭的治疗提供更加有效的药物选择。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 87-94(2024)

    • DOI：10.13422/j.cnki.syfjx.20240566    

      CLC： R22;R28;R541;R96

    • Published：05 June 2024，

      Published Online：21 December 2023，

      Received：09 September 2023，

    扫 描 看 全 文

  • SONG Yuying,CUI Lin,HE Yufeng,et al.Effect of Shenfu Yixin Granules on Mitochondrial Dynamics in Rats with Heart Failure After Myocardial Infarction[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):87-94. DOI： 10.13422/j.cnki.syfjx.20240566.

  •  
  •  

0

Views

18

下载量

0

CSCD

Alert me when the article has been cited
提交
Tools
Download
Export Citation
Share
Add to favorites
Add to my album

Related Articles

Effect of Yixintai on Mitochondrial Fission Proteins Fis1 and Mff in Rat Model of Chronic Heart Failure
Research Progress of Disease Developmental Process and Disease Dynamic Molecular Network Construction of "Myocardial Infarction-heart Failure"
Effect of Gualou Xiebai Banxiatang on Expression of Gal-3 in Rats After Myocardial Infarction

Related Author

SONG Yuying
CUI Lin
LIU Weihong
SHEN Si
LIU Chengxin
WEI Jiaming
WANG Ziyan
SHI Min

Related Institution

Henan Province Engineering Research Center of Safety Evaluation and Risk Management of Traditional Chinese Medicine，The First Affiliated Hospital of Henan University of Chinese Medicine Heart Center and Central Laboratory
First Clinical College of Chinese Medicine， School of Traditional Chinese Medicine （TCM），School of Pharmacy，Hunan Key Laboratory of Colleges and Universities of Intelligent TCM Diagnosis and Preventive Treatment of Chronic Diseases，Internet + TCM Diagnosis and Treatment of Chronic Diseases and Intelligent Application of Health Care Joint Postgraduate Training Base， Hunan University of Chinese Medicine
Experimental Research Center， China Academy of Chinese Medical Sciences
Tianjin University of Traditional Chinese Medicine
Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences
0