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Mechanism of Xiezhuo Jiedu Recipe in Preventing Colorectal Adenoma in Mice Through miRNA-34a-5p/PI3K/Akt Signalling Pathway
更新时间：2024-04-30
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    • Mechanism of Xiezhuo Jiedu Recipe in Preventing Colorectal Adenoma in Mice Through miRNA-34a-5p/PI3K/Akt Signalling Pathway

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    • “科技新闻播报：科研团队在结直肠腺瘤（CRA）领域取得了重要突破。该团队通过生物信息学方法，成功筛选出了CRA的关键微小RNA（miRNAs），并深入探讨了泄浊解毒方预防CRA的作用机制。研究团队首先利用基因表达谱数据库（GEO）获取了CRA患者肠黏膜组织的miRNAs数据集，通过一系列分析筛选出差异表达的miRNAs。其中，miR-34a-5p被选定为研究对象。进一步的研究发现，miR-34a-5p与PI3K/Akt信号通路、细胞周期、结直肠癌等途径密切相关。为了验证这一发现，研究团队进行了动物实验。他们采用葡聚糖硫酸钠（DSS）饮用联合氧化偶氮甲烷（AOM）腹腔注射方法诱导CRA小鼠模型，并给予泄浊解毒方进行干预。实验结果显示，泄浊解毒方可显著上调CRA小鼠结直肠组织中miR-34a-5p mRNA的水平，并抑制肠上皮细胞的异常增殖，促进细胞凋亡。这一研究成果为预防CRA提供了新的思路和方法。通过调控miR-34a-5p/PI3K/Akt信号通路，泄浊解毒方有望成为预防CRA的有效药物。未来，研究团队将继续深入探索这一机制，为CRA的治疗和预防提供更多科学依据。”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 30, Issue 11, Pages: 156-165(2024)

    • DOI：10.13422/j.cnki.syfjx.20240613    

      CLC： R285;R289;R287;R22;R2-031

    • Published：05 June 2024，

      Published Online：28 March 2024，

      Received：17 January 2024，

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  • JIA Sujie,SUN Chaodi,ZHANG Yifan,et al.Mechanism of Xiezhuo Jiedu Recipe in Preventing Colorectal Adenoma in Mice Through miRNA-34a-5p/PI3K/Akt Signalling Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(11):156-165. DOI： 10.13422/j.cnki.syfjx.20240613.

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