Varieties and Prescription Characteristics of Chinese Patent Medicines for Stroke in China

ZHANG Jingdan; SUN Wanping; LIN Xiaoxia; ZHANG Shuo; ZHANG Xue; YAO Jiahui; LIU Yiming; XIE Ming

doi:10.13422/j.cnki.syfjx.20241318

您当前的位置：

首页 >

文章列表页 >

Varieties and Prescription Characteristics of Chinese Patent Medicines for Stroke in China

更新时间：2025-03-04

- Varieties and Prescription Characteristics of Chinese Patent Medicines for Stroke in China
  增强出版
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 31, Issue 6, Pages: 270-274(2025)
- 作者机构：
  
  辽宁中医药大学药学院，辽宁大连 116000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20241318
  CLC： R289;R194;R743.2
- Received：22 May 2024，
  
  Accepted：29 October 2024，
  
  Published Online：05 September 2024，
  
  Published：20 March 2025
- 稿件说明：
移动端阅览
张兢丹,孙婉萍,林晓霞等.我国治疗脑卒中中成药上市品种及处方分析[J].中国实验方剂学杂志,2025,31(06):270-274.

ZHANG Jingdan,SUN Wanping,LIN Xiaoxia,et al.Varieties and Prescription Characteristics of Chinese Patent Medicines for Stroke in China[J].Chinese Journal of Experimental Traditional Medical Formulae,2025,31(06):270-274.
张兢丹,孙婉萍,林晓霞等.我国治疗脑卒中中成药上市品种及处方分析[J].中国实验方剂学杂志,2025,31(06):270-274. DOI： 10.13422/j.cnki.syfjx.20241318.

ZHANG Jingdan,SUN Wanping,LIN Xiaoxia,et al.Varieties and Prescription Characteristics of Chinese Patent Medicines for Stroke in China[J].Chinese Journal of Experimental Traditional Medical Formulae,2025,31(06):270-274. DOI： 10.13422/j.cnki.syfjx.20241318.

摘要

目的

该研究旨探讨我国治疗脑卒中中成药的上市品种及处方特点情况，探索治疗脑卒中的中医药规律，为进一步临床研究和中成药研发提供指导。

方法

运用Excel 2021、古今医案云平台（V2.3.5）对我国已上市脑卒中中成药的品种与处方进行系统的挖掘分析。

结果

最终纳入数据库的我国已经上市脑卒中中成药共有244个（同方不同剂型按2个计），中成药批文1 736个，生产厂家792家，中成药保护品种83个；剂型占比前三的分别是胶囊剂75个、丸剂53个、片剂42个；《国家基本药物目录（2018年）》中有脑卒中中成药28个，《国家基本医疗保险、工伤保险和生育保险药品目录（2023年）》中有129个，《国家非处方药目录》中有4个。根据筛选得出的138个处方中，主要治疗中风气虚血瘀证的中成药占多数，药味频数最高前3味是川芎63次、地龙47次、丹参47次；药性以温，药味以辛，药物归经以肝为主；通过中药关联分析得出支持度最高的药对为黄芪-川芎，置信度最高的为红花-川芎。根据聚类分析得出5组药物配对组合。

结论

治疗脑卒中中成药处方以治疗气虚血瘀证为主；药物主要涉及活血祛瘀、息风止痉等类别；药物配伍通常以活血化瘀、祛痰开窍为主。该研究梳理脑卒中中成药品种及处方特点，有助于优化临床决策、指导药品研发，并促进医学研究和科学进步，为脑卒中患者的治疗提供更加有效的支持和保障。

Abstract

Objective

To explore the listed varieties and prescription characteristics of Chinese patent medicines for stroke in China， explore the medication rules of Chinese medicine for stroke， and provide guidance for further clinical research and development of Chinese patent medicines.

Methods

Excel 2021 and the Ancient and Modern Medical Record Cloud Platform （V2.3.5） were used to systematically mine and analyze the varieties and prescriptions of Chinese patent medicines for stroke in China.

Results

A total of 244 Chinese patent medicines （two for different dosage forms of the same prescription）， 1 736 approval documents for Chinese patent medicines， 792 manufacturers， and 83 varieties of protected Chinese patent medicines were finally included in the database. The top three dosage forms were capsules （75）， pills （53）， and tablets （42）. There were 28 Chinese patent medicines for stroke in the National Essential Drug Catalogue （2018）， 129 in the National Essential Medical Insurance， Industrial Injury Insurance and Maternity Insurance Drug Catalogue （2023）， and 4 in the National Non-prescription Drug Catalogue. Among the 138 prescriptions screened out， Chinese patent medicines mainly treated stroke patients with the syndrome of Qi deficiency and blood stasis. The top three most frequent medicinal herbs were Chuanxiong Rhizoma （63）， Pheretima （47）， and Salviae Miltiorrhizae Radix et Rhizoma （47）. The medicinal herbs used were mainly warm， pungent， with the meridian tropism to the liver meridian. The correlation analysis showed that the herb pair with the highest support was Astragali Radix-Chuanxiong Rhizoma， and that with the highest confidence was Carthami Flos-Chuanxiong Rhizoma. Five herb combinations were identified based on the cluster analysis.

Conclusion

The Chinese patent medicines for stroke mainly treat patients with the syndrome of Qi deficiency and blood stasis. The medicinal herbs used in the prescriptions mainly have the functions of activating blood and resolving stasis， extinguishing wind and stopping convulsions. Drug compatibility usually focuses on activating blood and resolving stasis， as well as expelling phlegm and opening orifices. This review of the varieties and prescription characteristics of Chinese patent medicines for stroke helps optimize clinical decision-making， guide drug research and development， promote medical research and scientific progress， and provide more effective support and guarantee for the treatment of stroke patients.

关键词

Keywords

references

《中国卒中中心报告2019》概要［J］. 中国脑血管病杂志， 2021 ， 18 （ 5 ）： 355 - 360 .

Brief report on stroke center in China，2019 ［J］. Chin J Cerebrovascular Dis ， 2021 ， 18 （ 5 ）： 355 - 360 .

张伯礼，吴勉华 . 中医内科学［M］. 10版 . 北京：中国中医药出版社， 2017 ： 205 - 215 .

ZHANG B L ， WU M H . TCM internal medicine ［M］. 10th Edition . Beijing ： China Traditional Chinese Medicine Press ， 2017 ： 205 - 215 .

杨男，范红媛，田燕，等 . 我国中药药物经济学研究系统评价和质量评估［J］. 中国研究型医院， 2017 ， 4 （ 6 ）： 50 - 58 .

YANG N ， FAN H Y ， TIAN Y ， et al . Systematic analysis and quality evaluation for pharmacoeconomics researches on traditional Chinese medicine ［J］. Chin Res Hospitals ， 2017 ， 4 （ 6 ）： 50 - 58 .

国家药典委员会 . 中华人民共和国药典：一部［M］. 北京：中国医药科技出版社， 2020 .

Chinese pharmacopoeia commission . Pharmacopoeia of the People's republic of China：Part 1 ［M］. Beijing ： China Medical Science and Technology Press ， 2020 .

国家药典委员会 . 中华人民共和国卫生部药品标准：中药成方制剂［M］. 北京：中华人民共和国卫生部药典委员会， 1996 ： 26 - 254 ．

Chinese pharmacopoeia commission . Drug standard of the ministry of health of the people's republic of China： Chinese herbal formula preparations ［M］. Beijing ： Pharmacopoeia Committee of the Ministry of Health of the People's Republic of China ， 1996 ： 26 - 254 ．

国家食品药品监督管理局 . 国家中成药标准汇编［M］. 北京：人民卫生出版社， 2002 ： 105 - 200 ．

State food and drug administration . Compilation of national traditional Chinese patent medicines and simple preparations standards ［M］. Beijing ： People's Health Publishing House ， 2002 ： 105 - 200 ．

国家药典委员会 . 国家药品标准·新药转正标准：第77册［M］. 北京：中国医药科技出版社， 2011 ： 8 ．

Chinese Pharmacopoeia Commission . National drug standards·new drug confirmation standards：Volume 77 ［M］. Beijing ： China Medical Science and Technology Press ， 2002 ： 105 - 200 ．

国务院法制办公室 . 药品注册管理办法［M］. 北京：中国法制出版社， 2007 ： 1 - 9 ．

Legislative affairs office . Measures for the Administration of Drug Registration ［M］. Beijing ： China Legal Publishing House ， 2007 ： 1 - 9 ．

张伯礼，吴勉华 . 中医内科学［M］. 4版 . 北京：中国中医药出版社， 2017 ： 206 - 215 .

ZHANG B L ， WU M H . TCM internal medicine ［M］. 4th.Beijing ： China Traditional Chinese Medicine Press ， 2017 ： 206 - 215 .

钟赣生 . 中药学［M］. 北京：中国中医药出版社， 2016 ： 54 - 439 .

ZHONG G S . Traditional Chinese pharmacology ［M］. Beijing ： China Traditional Chinese Medicine Press ， 2016 ： 54 - 439 .

贾波，许二平 . 方剂学［M］. 北京：中国中医药出版社， 2021 ： 8 - 20 .

JIA B ， XU E P . Chinese herbal formulas ［M］. Beijing ： China Traditional Chinese Medicine Press ， 2021 ： 8 - 20 .

陈翠兰，陶京瑞，冯东山，等 . 中医开窍法治疗中风（脑血管病）危重患者的临床研究进展［J］. 中国中医急症， 2021 ， 30 （ 10 ）： 1855 - 1858，1866 .

CHEN C L ， TAO J R ， FENG D S ， et al . Clinical research progress on the treatment of stroke （cerebrovascular disease） critically ill patients with traditional Chinese medicine orifice opening method ［J］. J Emerg Tradit Chin Med ， 2021 ， 30 （ 10 ）： 1855 - 1858，1866 .

李立波 . 中风辨证分型与影像学诊断的相关性分析［J］. 吉林中医药， 2008 （ 9 ）： 640 - 641 .

LI L B . Correlation analysis between stroke syndrome differentiation and imaging diagnosis ［J］. Jilin J Chin Med ， 2008 （ 9 ）： 640 - 641 .

张宓，王乐，李中浩，等 . 基于数据挖掘分析《中华人民共和国药典》中治疗中风中成药的用药特点及处方的配伍规律［J］. 世界中西医结合杂志， 2023 ， 18 （ 6 ）： 1103 - 1108 .

ZHANG B ， WANG L ， LI Z H ， et al . Medication characteristics and compatibility rules of Chinese patent medicines against stroke included in the Chinese pharmacopoeia based on data mining ［J］. World J Int Tradit West Med ， 2023 ， 18 （ 6 ）： 1103 - 1108 .

LIU J Q ， DAI S X ， ZHENG J J ， et al . The identification and molecular mechanism of anti-stroke traditional Chinese medicinal compounds ［J］. Sci Rep ， 2017 ， 7 （ 1 ）： 41406 .

常学辉 . 黄帝内经［M］. 天津：天津科学技术出版社， 2015 . 12 ： 210 .

CHANG X H . Inner canon of Huangdi ［M］. Tianjin ： Tianjin Science and Technology Press ， 2015 ： 210 .

日华子 . 日华子本草（日华子本草蜀本草合刊本）［M］. 尚志钧，辑释.合肥：安徽科学技术出版社， 2005 ： 63 .

Rihuazi . Rihuazi Bencao（Rihuazi Bencao Shu Bencao Joint Edition）［M］. SHANG Z J . Hefei ： Anhui Science and Technology Press ， 2005 ： 63 .

袁巧，谢丽英，陈朝俊 . 黄芪多糖减轻大脑中动脉闭塞模型大鼠的血脑屏障损伤：基于抑制P2X7R通道［J］. 南方医科大学学报， 2022 ， 42 （ 11 ）： 1705 - 1711 .

YAN Q ， XIE L Y ， CHEN Z J . Astragalus polysaccharide protects against blood-brain barrier damage in MCAO rats by inhibiting P2X7R channel ［J］. J Southern Med Univ ， 2022 ， 42 （ 11 ）： 1705 - 1711 .

赵世英，张慧，邵笑笑，等 . 中药川芎治疗缺血性脑卒中的药理机制研究进展［J］. 辽宁中医药大学学报， 2024 ， doi： 21.1543.R.20240415.1641.031 http://dx.doi.org/21.1543.R.20240415.1641.031 .

ZHAO S Y ， ZHANG H ， SHAO X X ， et al . Progress on pharmacological mechanism of Chinese medicine Chuanxiong（Chuanxiong Rhizoma） in cerebral ischemic stroke ［J］. J Liaoning Univ Tradit Chin Med ， 2024 ， doi： 21.1543.R.20240415.1641.031 http://dx.doi.org/21.1543.R.20240415.1641.031 .

Views

300

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expert Consensus on Diagnosis and Management of Post-stroke Spasticity with Integrated Traditional Chinese and Western Medicine

Traditional Chinese Medicine Syndrome Classification and Characteristics of Cough Variant Asthma Based on Factor Analysis and Cluster Analysis

Mechanisms of Traditional Chinese Medicine in Prevention and Treatment of Stroke by Regulating Ferroptosis： A Review

Pharmacodynamic Substances and Mechanisms of Da Chengqitang in Treating Stroke： A Review

Related Author

LIN Yiming

Expert Consensus Writing Group of Professional Committee on Brain Diseases， Hunan Provincial Association of Chinese Medicine & Integration of Traditional and Western Medicine

YU Mingxia

LAN Ruiheng

LI Jiaqi

WANG Yanyan

CUI Hongsheng

WEI Mingyan

Related Institution

Third Affiliated Hospital of Beijing University of Chinese Medicine

The First Clinical Medical College of Shandong University of TCM

Affiliated Hospital of Shandong University of Traditional Chinese Medicine（TCM）

Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae，Ministry of Education，Tianjin University of Traditional Chinese Medicine

State Key Laboratory of Component-based Chinese Medicine， Tianjin University of Traditional Chinese Medicine

AI脑图

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰