Value of Serum <italic style="font-style: italic">D</italic>-Lactic Acid，I-FABP，and E-Selectin in Early Diagnosis of Infection After Gastrointestinal Surgery and Their Relationship with Curative Effect and TCM Syndromes

SHEN Xiaojun; LIU Yongpan; YU Senquan

doi:10.13422/j.cnki.syfjx.20250792

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Value of Serum D-Lactic Acid，I-FABP，and E-Selectin in Early Diagnosis of Infection After Gastrointestinal Surgery and Their Relationship with Curative Effect and TCM Syndromes

更新时间：2025-03-20

- Value of Serum D-Lactic Acid，I-FABP，and E-Selectin in Early Diagnosis of Infection After Gastrointestinal Surgery and Their Relationship with Curative Effect and TCM Syndromes
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 31, Issue 8, Pages: 159-166(2025)
- 作者机构：
  
  1.仙居县中医院，浙江仙居 317300
  2.浙江中医药大学附属第二医院（浙江省新华医院），杭州 310004
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20250792
  CLC： R259;R287;R619+.3
- Received：26 September 2024，
  
  Accepted：06 November 2024，
  
  Online First：12 November 2024，
  
  Published：20 April 2025
- 稿件说明：
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沈小军,刘勇攀,俞森权.血清D-乳酸、I-FABP、E选择素对胃肠道术后感染早期诊断价值及其与疗效、中医证型关系[J].中国实验方剂学杂志,2025,31(08):159-166.

SHEN Xiaojun,LIU Yongpan,YU Senquan.Value of Serum D-Lactic Acid，I-FABP，and E-Selectin in Early Diagnosis of Infection After Gastrointestinal Surgery and Their Relationship with Curative Effect and TCM Syndromes[J].Chinese Journal of Experimental Traditional Medical Formulae,2025,31(08):159-166.
沈小军,刘勇攀,俞森权.血清D-乳酸、I-FABP、E选择素对胃肠道术后感染早期诊断价值及其与疗效、中医证型关系[J].中国实验方剂学杂志,2025,31(08):159-166. DOI： 10.13422/j.cnki.syfjx.20250792.

SHEN Xiaojun,LIU Yongpan,YU Senquan.Value of Serum D-Lactic Acid，I-FABP，and E-Selectin in Early Diagnosis of Infection After Gastrointestinal Surgery and Their Relationship with Curative Effect and TCM Syndromes[J].Chinese Journal of Experimental Traditional Medical Formulae,2025,31(08):159-166. DOI： 10.13422/j.cnki.syfjx.20250792.

摘要

目的

探究血清

-乳酸、肠脂肪酸结合蛋白（I-FABP）、E选择素（Es）对胃肠道术后感染早期诊断价值及其与疗效、中医证型关系。

方法

选取2020年6月—2023年8月仙居县中医院收治的49例胃肠道术后腹腔感染患者作为感染组，53例胃肠道术后未感染患者作为非感染组。比较两组患者术后第1、3、5、7天血清

-乳酸、I-FABP、Es水平，Pearson分析各血清指标相关性，绘制受试者工作特征（ROC）曲线，基于曲线下面积（AUC）分析各血清指标诊断胃肠道术后感染价值，同时动态监测不同疗效患者治疗第1、3、5、7天各血清指标变化趋势，Logistic回归分析各血清指标与疗效关系，分析中医证型与血清学关系。

结果

两组患者第1、3、5、7天血清

-乳酸、I-FABP、Es水平逐渐下降，组间、时间、交互比较差异有统计学意义（

0.01）；第3天时，血清

-乳酸与I-FABP、Es水平呈正相关，I-FABP与Es呈正相关（

0.01）；术后第3天

-乳酸+I-FABP+Es联合诊断胃肠道术后感染价值的AUC为0.861，大于术后第3天

-乳酸的0.727、I-FABP的0.745，Es的0.797（

0.05）；感染缓解患者第1、3、5、7天血清

-乳酸、I-FABP、Es水平逐渐下降，感染加重患者逐渐升高，组间、时间、交互比较差异有统计学意义（

0.01）。患者中医证型分布依次为热毒证、急性虚证、血瘀证、腑气不通证，分别占61.22%、20.41%、12.24%、6.12%，患者不同证型、时间、交互比较差异均无统计学意义。

结论

血清

-乳酸、I-FABP、Es可用于胃肠道术后腹腔感染的早期诊断，指标变化也可反映患者感染治疗疗效及预后，但指标变化与中医证型之间并无明显相关性。

Abstract

Objective

To investigate the value of serum

-lactic acid，intestinal fatty acid binding protein （I-FABP），and E-selectin （Es） in early diagnosis of infection after gastrointest

inal surgery and their relationship with curative effect and traditional Chinese medicine （TCM） syndromes.

Methods

Forty-nine patients with abdominal infection after gastrointestinal surgery treated in Xianju County Traditional Chinese Medicine Hospital from June 2020 to August 2023 were selected as the infection group，and another 53 non-infected patients after gastrointestinal surgery were selected as the non-infected group. The serum

-lactic acid，I-FABP，and Es levels at the first，third，fifth， and seventh days after surgery were compared between the two groups，and the Pearson correlation coefficient was used to analyze the correlation of serum indexes. The receiver operating （ROC） curve and the area under the curve （AUC） of the patients were analyzed to analyze the value of each serum index in diagnosing infection after gastrointestinal surgery. At the same time，the serum indexes of patients with different therapeutic effects were monitored dynamically on the first，third，fifth， and seventh days of treatment. Logistic regression was used to analyze the relationship between serum indexes and curative effect. The relationship between TCM syndromes and serum indexes was analyzed.

Results

The levels of serum

-lactic acid，I-FABP，and Es in the two groups decreased on the first，third，fifth， and seventh days. There were significant differences among groups， time， and interaction （

0.01）. On the third day，serum

-lactic acid was positively correlated with I-FABP and Es，and I-FABP was positively correlated with Es （

0.01）. On the third day after surgery，the AUC of

-lactic acid + I-FABP + Es in the diagnosis of infection after gastrointestinal surgery was 0.861，higher than 0.727 of

-lactic acid，0.745 of I-FABP， and 0.797 of Es （

0.05）. The levels of serum

-lactic acid，I-FABP，and Es in patients wi

th remission infection were decreased continuously on the first，third，fifth，and seventh days. Patients with exacerbation of infection showed a continuous upward trend，and there were significant differences among groups， time， and interaction （

0.01）. The TCM syndromes of the patients were heat toxicity syndrome，acute deficiency syndrome，blood stasis syndrome， and fu-Qi obstruction syndrome，accounting for 61.22%，20.41%，12.24%， 6.12% respectively. There were no significant differences in different syndromes，time， and interaction.

Conclusion

Serum

-lactic acid，I-FABP，and Es can be used for early diagnosis of abdominal infection after gastrointestinal surgery，and the change of indicators can reflect the therapeutic effect and prognosis of patients with infection，but there is no significant correlation between the change of indicators and TCM syndromes.

关键词

Keywords

references

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⁰

Value of Serum D-Lactic Acid，I-FABP，and E-Selectin in Early Diagnosis of Infection After Gastrointestinal Surgery and Their Relationship with Curative Effect and TCM Syndromes

DOI：10.13422/j.cnki.syfjx.20250792

摘要

Abstract

关键词

Keywords

references