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Mechanisms of Improving Hippocampal Synaptic Plasticity Through GLP-1/GLP-1r Pathway to Alleviate Anxiety and Depression-like Behaviors in Chronic Restraint Stress Rats by Xiaoyaosan
更新时间：2025-12-24

    • Mechanisms of Improving Hippocampal Synaptic Plasticity Through GLP-1/GLP-1r Pathway to Alleviate Anxiety and Depression-like Behaviors in Chronic Restraint Stress Rats by Xiaoyaosan

    • “The latest research has found that Xiaoyao San can enhance synaptic plasticity and improve anxiety and depression like behavior in chronic restraint stress rats by activating GLP-1/GLP-1r in the hippocampal CA1 region and its mediated PKA/CREB/BDNF signaling pathway.”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 32, Issue 2, Pages: 34-42(2026)

    • DOI：10.13422/j.cnki.syfjx.20250837    

      CLC： R259;R285;R282

    • Received：09 February 2025，

      Revised：2025-04-12，

      Accepted：16 April 2025，

      Published：20 January 2026

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  • WANG Hao,YAN Yanan,WANG Jiepeng,et al.Mechanisms of Improving Hippocampal Synaptic Plasticity Through GLP-1/GLP-1r Pathway to Alleviate Anxiety and Depression-like Behaviors in Chronic Restraint Stress Rats by Xiaoyaosan[J].Chinese Journal of Experimental Traditional Medical Formulae,2026,32(02):34-42. DOI： 10.13422/j.cnki.syfjx.20250837.

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