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Mechanism of Xiaozheng Zhitong Paste in Alleviating Bone Cancer Pain by Regulating Microglial Pyroptosis Based on PINK1/Parkin/NLRP3 Signaling Pathway
更新时间：2026-02-28

    • Mechanism of Xiaozheng Zhitong Paste in Alleviating Bone Cancer Pain by Regulating Microglial Pyroptosis Based on PINK1/Parkin/NLRP3 Signaling Pathway

    • “The latest research has found that the XZP formula for relieving symptoms and pain significantly inhibits astrocyte pyroptosis by regulating the PINK1/Parkin mediated mitochondrial autophagy NLRP3 inflammasome pathway, effectively alleviating bone cancer pain and providing a new mechanism for related treatments.”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 32, Issue 5, Pages: 80-90(2026)

    • DOI：10.13422/j.cnki.syfjx.20251932    

      CLC： R277;R285;R289

    • Received：18 August 2025，

      Revised：2025-10-07，

      Accepted：13 October 2025，

      Online First：22 October 2025，

      Published：05 March 2026

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  • WANG Lingyun,ZHENG Guangda,SHANG Lu,et al.Mechanism of Xiaozheng Zhitong Paste in Alleviating Bone Cancer Pain by Regulating Microglial Pyroptosis Based on PINK1/Parkin/NLRP3 Signaling Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2026,32(05):80-90. DOI： 10.13422/j.cnki.syfjx.20251932.

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Related Author

WANG Lingyun
SHANG Lu
REN Juanxia
LI Changlin
CHEN Yaohua
YANG Guiping
CHEN Chang
GUO Ziwen

Related Institution

The First Clinical College， Liaoning University of Traditional Chinese Medicine
Xining Hospital of Traditional Chinese Medicine
School of Elderly Care Services and Management， Nanjing University of Chinese Medicine
Drum Tower Clinical Medical College， Nanjing University of Chinese Medicine
School of Integrative Medicine， Nanjing University of Chinese Medicine
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