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Xiaozheng Zhitong Paste Alleviates Bone Cancer Pain of Mice by Reducing Ferroptosis in Spinal Cord Tissue and Neuronal Damage via Regulating Nrf2/HO-1/GPX4/SLC7A11 Signaling Pathway
更新时间：2026-02-28

    • Xiaozheng Zhitong Paste Alleviates Bone Cancer Pain of Mice by Reducing Ferroptosis in Spinal Cord Tissue and Neuronal Damage via Regulating Nrf2/HO-1/GPX4/SLC7A11 Signaling Pathway

    • “The latest research has found that XZP, an external formula for relieving symptoms and pain, can alleviate bone cancer pain (BCP). Experts have established a mouse BCP model and found that XZP can activate the Nrf2/HO-1/GPX4/SLC7A11 pathway, inhibit spinal neuron ferroptosis and injury, alleviate pain symptoms, and provide new ideas for the treatment of bone cancer pain.”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 32, Issue 5, Pages: 101-113(2026)

    • DOI：10.13422/j.cnki.syfjx.20252038    

      CLC： R277;R285;R289

    • Received：26 August 2025，

      Revised：2025-10-25，

      Accepted：27 October 2025，

      Online First：31 October 2025，

      Published：05 March 2026

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  • REN Juanxia,SHANG Lu,ZHENG Guangda,et al.Xiaozheng Zhitong Paste Alleviates Bone Cancer Pain of Mice by Reducing Ferroptosis in Spinal Cord Tissue and Neuronal Damage via Regulating Nrf2/HO-1/GPX4/SLC7A11 Signaling Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2026,32(05):101-113. DOI： 10.13422/j.cnki.syfjx.20252038.

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Related Author

SHANG Lu
REN Juanxia
WANG Lingyun
LI Changlin
CHEN Yaohua
YANG Guiping
BAO Yanju
ZHENG Guangda

Related Institution

Liaoning University of Traditional Chinese Medicine（TCM）
Xining Municipal Hospital of TCM
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Xining Municipal Hospital of Traditional Chinese Medicine
China Academy of Chinese Medical Sciences
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