浏览全部资源
扫码关注微信
Pharmacological Effect of Glycyrrizae Radix et Rhizoma Compatibility and Its Mechanism
增强出版- Chinese Journal of Experimental Traditional Medical Formulae Vol. 28, Issue 14, Pages: 270-282(2022)
- 作者机构：
1.广西中医药大学 中国-东盟传统药物研究国际合作联合实验室，南宁 530200
2.广西中医药大学 广西中药药效研究重点实验室，南宁 530000
3.中国中医科学院 望京医院，北京 100102
4.北京市隆福医院，北京 100010
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20220816
CLC： R284.2;R285;R289;R22;R2-031;R33Published：20 July 2022，
Published Online：19 April 2022，
Received：08 December 2021，
- 稿件说明：
扫 描 看 全 文
李泽宇,郝二伟,李卉等.甘草配伍应用的药理作用及机制分析[J].中国实验方剂学杂志,2022,28(14):270-282.
LI Zeyu,HAO Erwei,LI Hui,et al.Pharmacological Effect of Glycyrrizae Radix et Rhizoma Compatibility and Its Mechanism[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(14):270-282.
李泽宇,郝二伟,李卉等.甘草配伍应用的药理作用及机制分析[J].中国实验方剂学杂志,2022,28(14):270-282. DOI： 10.13422/j.cnki.syfjx.20220816.
LI Zeyu,HAO Erwei,LI Hui,et al.Pharmacological Effect of Glycyrrizae Radix et Rhizoma Compatibility and Its Mechanism[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(14):270-282. DOI： 10.13422/j.cnki.syfjx.20220816.
摘要
甘草药用价值高，配伍应用广泛，在中药方剂配伍中使用频率最高，被称为“国老” “众药之主”，特征活性成分以甘草苷、甘草酸、甘草素、甘草查尔酮等为主，其基于传统和现代药理学理论，在不同的配伍应用中通过不同的作用机制发挥相应的功效。该文首先基于甘草补脾益气、清热解毒、祛痰止咳、缓急止痛、调和诸药的传统药理，应用本草考证的方法对其配伍应用和机制进行了分析，发现其可通过“补” “和” “调”在配伍中发挥相应功效，如配伍人参、白术等补药用于补益五脏是基于其强大的补虚作用，配伍芍药、附子等用于多种急症和痛症是基于其缓和药力、药性的作用，配伍大黄、芒硝用于降其烈性是基于其调和药性及机体的特性等。应用数据挖掘和网络药理学的方法对其现代药理配伍的应用规律和机制进行了分析，发现现代临床方剂常配伍甘草用于抗炎、保护心脑血管及神经、抗病毒、抗肿瘤，配伍麻黄、黄芩用于抗炎，配伍竹茹、丹参、枳实用于保护心脑血管，配伍麦冬、川芎用于保护神经等，同时确定了其特征性成分发挥相关作用的重要靶点为蛋白激酶B（Akt）1、白细胞介素（IL）-6、肿瘤坏死因子（TNF）、表皮生长因子受体（EGFR）等，其中发挥心脑血管保护作用的重要特征通路为酪氨酸激酶抑制剂耐药性通路、环磷酸鸟苷（cGMP）/PKG信号通路，发挥神经保护作用的重要特征通路为癌症中的蛋白多糖通路等，以期为甘草的合理配伍应用提供一定的基础和思路，同时为广大中药复方的配伍应用研究提供一定的方法和借鉴意义。
Abstract
Glycyrrizae Radix et Rhizoma has high medicinal value and is widely used in compatibility. It is used most frequently in the compatibility of Chinese medicine prescriptions，and is known as ''Guolao''（national medicine） and "master of all medicines". The characteristic active ingredients are mainly liquitin，glycyrrizic acid，glycyrrizin，and licochalcone. In different compatibilities，based on traditional and modern pharmacological theories，the corresponding effect of Glycyrrizae Radix et Rhizoma are brought into play through different mechanisms. Based on the traditional pharmacology of Glycyrrizae Radix et Rhizoma for tonifying spleen，replenishing Qi，clearing heat，removing toxin，dispelling phlegm，relieving cough and pain，and harmonizing various medicines，this paper used herbal authentication to analyze its compatibility application and mechanism. It was found that Glycyrrizae Radix et Rhizoma played corresponding effect in compatibilities through "tonification"，"harmonization"，and "regulation". For example，Glycyrrizae Radix et Rhizoma was combined with tonics including Ginseng Radix et Rhizoma and Atractylodis Macrocephalae Rhizoma to tonify the five Zang-organs through its strong tonifying effect，combined with Paeoniae Radix Alba and Aconiti Lateralis Radix Praeparata to relieve emergencies and pains through harmonizing medicine power and properties，and combined with Rhei Radix et Rhizoma and Natrii Sulfas to reduce medicine intensity through regulating medicine properties and body characteristics. The application law and mechanism of the modern pharmacological compatibility of Glycyrrizae Radix et Rhizoma were analyzed by data mining and network pharmacology. It was found that the modern clinical formula was often compatible with Glycyrrizae Radix et Rhizoma for anti-inflammation，cardiovascular and cerebrovascular protection，anti-virus，and anti-tumor，Ephedrae Herba and Scutellariae Radix for anti-inflammation，Bambusae Caulis in Taenias，Salviae Miltiorrhizae Radix et Rhizoma，and Aurantii Fructus Immaturus for cardiovascular and cerebrovascular protection，and Ophiopogonis Radix and Chuanxiong Rhizoma for nerves protection. Meanwhile，the important targets of the characteristic ingredients were protein kinase B1 （Akt1），interleukin-6 （IL-6），tumor necrosis factor （TNF），and epidermal growth factor receptor （EGFR）. The important characteristic pathways such as tyrosine kinase inhibitor resistance pathway and cyclic guanosine monophosphate （cGMP）/protein kinase G （PKG） signal pathway played the role of cardiovascular and cerebrovascular protection，and proteoglycan pathway in cancer played a neuroprotective role. This study is expected to provide references for the rational compatibility and application of Glycyrrizae Radix et Rhizoma，as well as the compatibility application of Chinese medicine prescriptions.
关键词
甘草配伍化学成分药理作用临床应用机制本草考证数据挖掘网络药理学
Keywords
Glycyrrizae Radix et Rhizomacompatibilitypharmacological effectchemical compositionclinical applicationmechanismherbal authenticationdata miningnetwork pharmacology
references
国家药典委员会.中华人民共和国药典：一部［M］.北京：中国医药科技出版社，2020：88.
高晓娟，赵丹，赵建军，等.甘草的本草考证［J］.中国实验方剂学杂志，2017，23（2）：193-198.
张元素.医学启源［M］.北京：中国中医药出版社，2007：103.
高学敏.中药学［M］.北京：中国中医药出版社，2002：507.
杨时泰.本草述钩元［M］.北京：华夏出版社，1999：168.
赵佶.圣济总录［M］.北京：人民卫生出版社，1962：372.
张仲景.伤寒论［M］.北京：人民卫生出版社，2005：4.
许国桢，王淑民，关雪点.御药院方［M］.北京：人民卫生出版社，1992：108.
曹玉洁，唐于平，沈娟，等.基于数据挖掘分析甘草药对配伍应用规律［J］.中草药，2017，48（21）：4552-4559.
缪希雍.神农本草经疏［M］.北京：华夏出版社，1999：418.
张德裕.本草正义［M］.北京：华夏出版社.1999：479.
KUANG Y，LI B，FAN J，et al.Antitussive and expectorant activities of licorice and its major compounds［J］.Bioorg Med Chem，2018，26（1）：278-284.
陈伟，马磊，杨立山.甘草次酸对支气管哮喘大鼠IgE、IL-4及TNF-α的影响［J］.中药药理与临床，2015，31（3）：52-55.
陈伟，马磊，杨立山.甘草次酸对哮喘大鼠气道重塑及肺组织Casepase-3、Bax、Bcl-2表达的影响［J］.中药药理与临床，2016，32（4）：16-19.
LIU C，YANG N，CHEN X，et al.The flavonoid 7，4'-dihydroxyflavone prevents dexamethasone paradoxical adverse effect on eotaxin production by human fibroblasts［J］.Phytother Res，2017，31（3）：449-458.
LIU C，WEIR D，BUSSE P，et al.The flavonoid 7，4'-dihydroxyflavone inhibits MUC5AC gene expression，production，and secretion via regulation of NF-κB，STAT6，and HDAC2［J］.Phytother Res，2015，29（6）：925-932.
王好古.汤液本草［M］.北京：华夏出版社，1999：55.
刘文泰.本草品汇精要［M］.北京：华夏出版社，1999：894.
沈金鳌.要药分剂［M］.北京：华夏出版社，1999：442.
张锡纯.医学衷中参西录［M］.河北新医大学《医学衷中参西录》修订小组，修订.石家庄：河北人民出版社，1977：74.
王文萍，王垂杰，谷松，等.芍药甘草汤配伍意义的药动学研究［J］.世界科学技术—中医药现代化，2009，11（3）：382-387.
李时珍.本草纲目［M］.北京：华夏出版社，1999：514.
刘昉撰.幼幼新书［M］.北京：人民卫生出版社，1987：800.
王怀隐.太平圣惠方［M］.北京：人民卫生出版社，1958：143.
田圣志，赖宝林，施钧翰，等.甘草解毒作用研究进展［J］.世界中西医结合杂志，2008，3（9）：560-562.
薛己.本草约言［M］.北京：华夏出版社，1999：191.
LI N，ZHOU T，WU F，et al.Pharmacokinetic mechanisms underlying the detoxification effect of Glycyrrhizae Radix et Rhizoma （Gancao）：Drug metabolizing enzymes，transporters，and beyond［J］.Expert Opin Drug Metab Toxicol，2019，15（2）：167-177.
HE Y，CI X，XIE Y，et al.Potential detoxification effect of active ingredients in liquorice by upregulating efflux transporter［J］.Phytomedicine，2019，56：175-182.
解素花，张广平，孙桂波，等.附子与甘草不同配伍比例配伍减毒的实验研究［J］.中国中药杂志，2012，37（15）：2210-2214.
王志琪，曾嵘，谭志荣，等.附子与甘草配伍前后乌头碱和甘草次酸在大鼠体内的药动学比较［J］.中成药，2012，34（12）：2305-2309.
王焘.外台秘要方［M］.高文铸，校注.北京：华夏出版社，1993：753.
陶弘景.本草经集注［M］.北京：华夏出版社，1999：91.
倪朱谟.本草汇言［M］.北京：华夏出版社，1999：51.
ZHANG Y，ZHANG L，ZHANG Y，et al.The protective role of liquiritin in high fructose-induced myocardial fibrosis via inhibiting NF-κB and MAPK signaling pathway［J］.Biomed Pharmacother，2016，84：1337-1349.
WANG W，HU X，ZHAO Z，et al.Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice［J］.Prog Neuropsychopharmacol Biol Psychiatry，2008，32（5）：1179-1184.
WANG J R，LI T Z，WANG C，et al.Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/Akt/NF-κB signaling pathway［J］.Naunyn Schmiedebergs Arch Pharmacol，2020，393（10）：1987-1999.
XIE R，GAO C C，YANG X Z，et al.Combining TRAIL and liquiritin exerts synergistic effects against human gastric cancer cells and xenograft in nude mice through potentiating apoptosis and ROS generation［J］.Biomed Pharmacother，2017，93：948-960.
WEI F，JIANG X，GAO H Y，et al.Liquiritin induces apoptosis and autophagy in cisplatin （DDP）-resistant gastric cancer cells in vitro and xenograft nude mice in vivo［J］.Int J Oncol，2017，51（5）：1383-1394.
HE S H，LIU H G，ZHOU Y F，et al.Liquiritin （LT） exhibits suppressive effects against the growth of human cervical cancer cells through activating Caspase-3 in vitro and xenograft mice in vivo［J］.Biomed Pharmacother，2017，92：215-228.
ZHU J，DENG Y Q，WANG X，et al. An artificial intelligence system reveals liquiritin inhibits SARS-CoV-2 by mimicking type I interferon［J］.Bio Rxiv，2020，doi：10.1101/2020.05.02.074021http://dx.doi.org/10.1101/2020.05.02.074021.
ZHANG Y，ZHANG L，ZHANG Y，et al.The protective role of liquiritin in high fructose-induced myocardial fibrosis via inhibi- ting NF-κB and MAPK signaling pathway［J］.Biomed Pharmacother，2016，84：1337.
XU C，LIANG C，SUN W，et al.Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state［J］.Drug Des Devel Ther，2018，12：1311-1319.
RASHEDINIA M，SABERZADEH J，KHOSRAVI BAKHTIARI T，et al.Glycyrrhizic acid ameliorates mitochondrial function and biogenesis against aluminum toxicity in PC12 cells［J］.Neurotox Res，2019，35（3）：584-593.
王永洪，兰婉莹，陈恬.甘草酸体外抗人巨细胞病毒AD169的作用［J］.中成药，2016，38（10）：2121-2127.
YU S，ZHU Y，XU J，et al.Glycyrrhizic acid exerts inhibitory activity against the spike protein of SARS-CoV-2［J］.Phytomedicine，2021，85：153364.
CAI S，BI Z，BAI Y，et al.Glycyrrhizic acid-induced differentiation repressed stemness in hepatocellular carcinoma by targeting c-Jun N-terminal kinase 1［J］.Front Oncol，2019，9：1431.
HUO X W，YANG S，SUN X K，et al.Protective effect of glycyrrhizic acid on alcoholic liver injury in rats by modulating lipid metabolism ［J］.Molecules，2018，23（7）：E1623.
HAN S，SUN L，HE F，et al.Anti-allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells［J］.Sci Rep，2017，7（1）：7222.
苏丽，王锃，黄菲，等.甘草次酸减轻放射性炎症反应的作用机制研究［J］.中国临床药理学与治疗学，2016，21（10）：1088-1094.
SHIN H，CHUNG M，ROSE D Z.Licorice root associated with intracranial hemorrhagic stroke and cerebral microbleeds［J］.Neurohospitalist，2019，9（3）：169-171.
MIRZA M U，MIRZA A H，GHORI N U，et al.Glycyrrhetinic acid and E.resveratroloside act as potential plant derived compounds against dopamine receptor D3 for Parkinson's disease：A pharmacoinformatics study［J］.Drug Des Devel Ther，2015，9：187-198.
王元花，阎芳，金永生.甘草有效成分的提取及协同氟康唑抗真菌活性研究［J］.药学服务与研究，2017，17（3）：218-222.
朱世超，郑学敏，张玥，等.甘草次酸衍生物抗肝纤维化的实验研究［J］.中草药，2017，48（17）：3554-3559.
PAUDEL Y N，ANGELOPOULOU E，SEMPLE B，et al.Potential neuroprotective effect of the HMGB1 inhibitor glycyrrhizin in neurological disorders［J］.ACS Chem Neurosci，2020，11（4）：485-500.
SU Q，TAO W，HUANG H，et al.Protective effect of liquiritigenin on depressive-like behavior in mice after lipopolysaccharide administration［J］.Psychiatry Res，2016，240：131-136.
TAO W，DONG Y，SU Q，et al.Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway［J］.Behav Brain Res，2016，308：177-186.
KO Y H，KWON S H，LEE S Y，et al.Liquiritigenin ameliorates memory and cognitive impairment through cholinergic and BDNF pathways in the mouse hippocampus［J］.Arch Pharm Res，2017，40（10）：1209-1217.
WANG J R，LUO Y H，PIAO X J，et al.Mechanisms underlying isoliquiritigenin-induced apoptosis and cell cycle arrest via ROS-mediated MAPK/STAT3/NF-κB pathways in human hepatocellular carcinoma cells［J］.Drug Dev Res，2019，80（4）：461-470.
MENG F C，LIN J K.Liquiritigenin inhibits colorectal cancer proliferation，invasion，and epithelial-to-mesenchymal transition by decreasing expression of runt-related transcription factor 2［J］.Oncol Res，2019，27（2）：139-146.
GAUR R，YADAV K S，VERMA R K，et al.In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin［J］.Phytomedicine，2014，21（4）：415-422.
UCHINO K，OKAMOTO K，SAKAI E，et al.Dual effects of liquiritigenin on the proliferation of bone cells：Promotion of osteoblast differentiation and inhibition of osteoclast differentiation［J］.Phytother Res，2015，29（11）：1714-1721.
CHI J H，SEO G S，CHEON J H，et al.Isoliquiritigenin inhibits TNF-α-induced release of high-mobility group box 1 through activation of HDAC in human intestinal epithelial HT-29 cells［J］.Eur J Pharmacol，2017，796：101-109.
YU H，LI H，LI Y，et al.Effect of isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice［J］.Arch Dermatol Res，2017，309（10）：805-813.
QI J，CUI J，MI B，et al.Isoliquiritigenin Inhibits Atherosclerosis by Blocking TRPC5 Channel Expression［J］.Cardiovasc Ther，2020，2020：1926249.
张沛，卢宝全，杨洁.异甘草素联合骨髓间充质干细胞在脑梗死大鼠中的保护作用［J］.中国免疫学杂志，2020，36（3）：305-310.
WU C H，CHEN H Y，WANG C W，et al.Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice［J］.Oncotarget，2016，7（45）：73432-73447.
CHEN C，HUANG S，CHEN C L，et al.Isoliquiritigenin inhibits ovarian cancer metastasis by reversing epithelial-tomesenchymal transition ［J］.Molecules，2019，24（20）：3725.
XIANG S，CHEN H，LUO X，et al.Isoliquiritigenin suppresses human melanoma growth by targeting miR-301b/LRIG1 signaling［J］.J Exp Clin Cancer Res，2018，37（1）：184.
KIM D H，PARK J E，CHAE I G，et al.Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway［J］.Oncol Rep，2017，38（1）：575-583.
ZHANG B-Y，LAI Y，LI Y-F，et al.Antineoplastic activity of isoliquiritigenin，a chalcone compound，in androgenindependent human prostate cancer cells linked to G2/M cell cycle arrest and cell apoptosis［J］.Eur J Pharmacol，2018，821：57-67.
SEON M R，PARK S Y，KWON S J，et al.Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells［J］.J Nutr Biochem，2012，23（1）：85-92.
SAWADA K，YAMASHITA Y，ZHANG T，et al.Glabridin induces glucose uptake via the AMP-activated protein kinase pathway in muscle cells［J］.Mol Cell Endocrinol，2014，393（1-2）：99-108.
CHOI E M.Glabridin protects osteoblastic MC3T3-E1 cells against antimycin A induced cytotoxicity［J］.Chem Biol Interact，2011，193（1）：71-78.
WU Y，ZHU J，LIU H，et al.Licochalcone A improves the cognitive ability of mice by regulating T- and B-cell proliferation［J］.Aging （Albany NY），2021，13（6）：8895-8915.
CAO Y，LEI E，WANG X，et al.Licochalcone A inhibits enterovirus A71 replication in vitro and in vivo［J］.Antiviral Res，2021，195：105091.
辛红，徐巍.甘草查尔酮A通过PI3K/Akt/mTOR信号通路诱导肾癌细胞自噬的研究［J］.中国中药杂志，2018，43（17）：3545-3552.
LIU X，XING Y，LI M，et al.Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-κB and Ras/Raf/MEK pathways［J］.J Ethnopharmacol，2021，273：113989.
CAO Y，XU W，HUANG Y，et al.Licochalcone B，a chalcone derivative from Glycyrrhiza inflata，as a multifunctional agent for the treatment of Alzheimer's disease［J］.Nat Prod Res，2020，34（5）：736-739.
OH H N，LEE M H，KIM E，et al.Licochalcone B inhibits growth and induces apoptosis of human non-small-cell lung cancer cells by dual targeting of EGFR and MET［J］.Phytomedicine，2019，63：153014.
WANG J，LIAO A M，THAKUR K，et al.Licochalcone B Extracted from Glycyrrhiza uralensis Fisch induces apoptotic effects in human hepatoma cell HepG2［J］.J Agric Food Chem，2019，67（12）：3341-3353.
SONG M，YOON G，CHOI J S，et al.Janus kinase 2 inhibition by licochalcone B suppresses esophageal squamous cell carcinoma growth［J］.Phytother Res，2020，34（8）：2032-2043.
SI L，YAN X，HAO W，et al.Licochalcone D induces apoptosis and inhibits migration and invasion in human melanoma A375 cells［J］.Oncol Rep，2018，39（5）：2160-2170.
SEO J H，CHOI H W，OH H N，et al.Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma［J］.J Cell Physiol，2019，234（2）：1780-1793.
KIM S S，LIM J，BANG Y，et al.Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells：Therapeutic relevance to neurodegenerative disease［J］.J Nutr Biochem，2012，23（10）：1314-1323.
BAK E J，CHOI K C，JANG S，et al.Licochalcone F alleviates glucose tolerance and chronic inflammation in diet-induced obese mice through Akt and p38 MAPK［J］.Clin Nutr，2016，35（2）：414-421.
KWAK A W，CHO S S，YOON G，et al.Licochalcone H synthesized by modifying structure of licochalcone c extracted from Glycyrrhiza inflata induces apoptosis of esophageal squamous cell carcinoma cells［J］.Cell Biochem Biophys，2020，78（1）：65-76.
PARK K H，JOO S H，SEO J H，et al.Licochalcone H induces cell cycle arrest and apoptosis in human skin cancer cells by modulating JAK2/STAT3 signaling［J］.Biomol Ther （Seoul），2022，30（1）：72-79.
金亚香，张研，刘天戟，等.甘草水提物对大鼠C-BSA肾炎模型治疗作用的研究［J］.世界临床药物，2016，37（1）：29-32.
CHO J，KWEON H S，HUH S O，et al.Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflata［J］.Anim Cells Syst （Seoul），2018，22（3）：189-196.
杨晓露，刘朵，卞卡，等.甘草总黄酮及其成分体外抗炎活性及机制研究［J］.中国中药杂志，2013，38（1）：99-104.
费书珂，张靓，何苦寒.甘草皂苷对小鼠急性胰腺炎疗效及机制研究［J］.中国现代医学杂志，2014，24（19）：26-29.
CHANG K H，CHEN I C，LIN H Y，et al.The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer's disease［J］.Drug Des Devel Ther，2016，10：885-896.
崔永明，余龙江，丁巧，等.甘草醇提物对大鼠学习记忆障碍的影响［J］.中国老年学杂志，2008，28（12）：1055-1057.
程瑞凤，景晶，华冰，等.甘草总黄酮提取部位抗小鼠抑郁活性可能与其增强中枢5-羟色胺能神经功能有关［J］.中国药理学与毒理学杂志，2014，28（4）：484-490.
程瑞凤，华冰，景晶，等.甘草总黄酮抗大鼠应激抑郁行为作用及对海马脑区神经细胞凋亡调控相关蛋白表达的影响［J］.中药药理与临床，2014，30（2）：69-72.
WANG Y，WANG X，ZHANG K，et al.Extraction kinetics，thermodynamics，rheological properties and anti-BVDV activity of the hot water assisted extraction of Glycyrrhiza polysaccharide［J］.Food Funct，2020，11（5）：4067-4080.
ZHOU P，YANG X L，WANG X G，et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin［J］.Nature，2020：579（7798）：270-273.
ZHANG X，ZHAO S，SONG X，et al.Inhibition effect of glycyrrhiza polysaccharide （GCP） on tumor growth through regulation of the gut microbiota composition［J］.J Pharmacol Sci，2018，137（4）：324-332.
HINZ N，JüCKER M.Distinct functions of Akt isoforms in breast cancer：A comprehensive review［J］.Cell Commun Signal，2019，17（1）：154.
MARTíNEZ-RODRíGUEZ O P，THOMPSON-BONILLA M，JARAMILLO-FLORES M E.Association between obesity and breast cancer：Molecular bases and the effect of flavonoids in signaling pathways［J］.Crit Rev Food Sci Nutr，2020，60（22）：3770-3792.
LI J，ZHANG H，HUANG W，et al.TNF-α inhibitors with anti-oxidative stress activity from natural products［J］.Curr Top Med Chem，2012，12（13）：1408-1421.
CHATZANTONI K，MOUZAKI A.Anti-TNF-alpha antibody therapies in autoimmune diseases［J］.Curr Top Med Chem，2006，6（16）：1707-1714.
QIAN Y，HAN J，ZHOU L，et al.Inhibition of epidermal growth factor receptor （EGFR） reduces lipopolysaccharide （LPS）-induced activation and inflammatory cytokines in hepatic stellate cells in vitro［J］.Med Sci Monit，2018，24：5533-5541.
MICHALOPOULOS G K.Principles of liver regeneration and growth homeostasis［J］.Compr Physiol，2013，3（1）：485-513.
URIBE M L，MARROCCO I，YARDEN Y.EGFR in cancer：Signaling mechanisms，drugs，and acquired resistance［J］.Cancers （Basel），2021，13（11）：2748.
0
Views
14
下载量
14
CSCD
- H-PDFDownload
- L-PDFDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Postal code：100700
- Tel：010-84076882 Email：syfjx_2010@188.com
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
