Application Law of Coptidis Rhizoma to Diabetes and Its Complications： Based on Data Mining

Lingxiao ZHAO; Hong LYU; Xinghua HU; Yuan GAO; Houli LIU; Ling LI; Jianqin XU

doi:10.13422/j.cnki.syfjx.20220911

您当前的位置：

首页 >

文章列表页 >

Application Law of Coptidis Rhizoma to Diabetes and Its Complications： Based on Data Mining

更新时间：2022-09-01

- Application Law of Coptidis Rhizoma to Diabetes and Its Complications： Based on Data Mining
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 28, Issue 14, Pages: 158-164(2022)
- 作者机构：
  
  1.陕西中医药大学研究生院，陕西咸阳 710042
  2.陕西省中医医院，西安 710003
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20220911
  CLC： R285;R289;R22;R2-031;R33
- Published：20 July 2022，
  
  Published Online：20 May 2022，
  
  Received：01 February 2022，
- 稿件说明：
扫描看全文
赵凌霄,吕红,呼兴华等.基于数据挖掘探讨黄连在糖尿病及其并发症复方中的应用规律[J].中国实验方剂学杂志,2022,28(14):158-164.

ZHAO Lingxiao,LYU Hong,HU Xinghua,et al.Application Law of Coptidis Rhizoma to Diabetes and Its Complications： Based on Data Mining[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(14):158-164.
赵凌霄,吕红,呼兴华等.基于数据挖掘探讨黄连在糖尿病及其并发症复方中的应用规律[J].中国实验方剂学杂志,2022,28(14):158-164. DOI： 10.13422/j.cnki.syfjx.20220911.

ZHAO Lingxiao,LYU Hong,HU Xinghua,et al.Application Law of Coptidis Rhizoma to Diabetes and Its Complications： Based on Data Mining[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(14):158-164. DOI： 10.13422/j.cnki.syfjx.20220911.

摘要

目的

基于数据挖掘探讨黄连在糖尿病及其并发症复方中的应用规律。

方法

检索并收集现代医家的医案中含有黄连治疗糖尿病及其并发症的方剂及对应的证型、症状的数据共288条（其中黄连治疗糖尿病218条，黄连治疗糖尿病并发症70条），运用“中医传承计算平台（V3.0）”对该方药组成进行数据挖掘分析，利用该平台的频数统计、方剂分析、症状分析、关联规则、网络可视化图、聚类分析等进行数据挖掘。

结果

对288条数据挖掘分析，方案1：218首含黄连治疗糖尿病的方剂中，共包含中药190味，对含有黄连的处方证型频率统计，出现频数≥6次的证候有12种，其中出现频率最高的是气阴两虚证，其后依次为肺胃热盛证、阴虚火旺证、热盛津伤证等。黄连治疗糖尿病的用量为1.5~30 g，频数最高位于前三的用量为10、6、5 g，相对应医案中症状频数最高是大便干结、口干舌燥、消谷善饥，通过关联规则和聚类分析共得出26条核心药对、17条关联规则、3张药物关系图以及3个核心组合。方案2：70首含黄连治疗糖尿病并发症的方剂中，共包含有184味中药，黄连治疗糖尿病并发症的疾病分布排名前3的为糖尿病肾病、糖尿病周围神经病变、糖尿病胃肠病变，黄连治疗糖尿病并发症的用量及频数分析可见黄连的用量为2~15 g，频数最高位于前三的用量为10、6、5 g。

结论

含黄连治疗糖尿病及其并发症的方剂，多兼有湿热化火、热盛伤阴症状。本次总结黄连用量规律，为临床规范使用黄连防治糖尿病及其并发症提供了参考。

Abstract

Objective

To explore the application law of compound prescriptions containing Coptidis Rhizoma to diabetes and its complications based on data mining.

Method

A total of 288 records on formulas containing Coptidis Rhizoma in the treatment of diabetes and its complications and the corresponding syndromes and symptoms were retrieved from the medical records of modern physicians， with 218 on the treatment of diabetes and 70 on the treatment of diabetes complications. The Traditional Chinese Medicine Inheritance Computing Platform （V3.0） was used or data mining on the compositions of the formulas. Moreover， it was employed for the frequency statistics， formula analysis， symptom analysis， association rules analysis， network visualization， and cluster analysis.

Result

The 218 formulas containing Coptidis Rhizoma for the treatment of diabetes involved 190 Chinese medicinals. A total of 12 syndromes showed the occurrence frequency ≥ 6， and the one with the highest frequency was deficiency of both qi and yin， followed by the syndrome of excessive heat in lung and stomach， syndrome of Yin deficiency and effulgent fire， and syndrome of excessive heat and fluid consumption. The dose of Coptidis Rhizoma for the treatment of diabetes ranged from 1.5-30 g， and the most frequently used doses were 10， 6， and 5 g. The medicinal was frequently applied for the traditional Chinese medicine symptoms of dry stool， dry mouth and tongue， and swift digestion with rapid hungering. Moreover， 26 core medicinal pairs， 17 association rules， 3 diagrams on medicinal relationship， and 3 core combinations were yielded. The 70 formulas containing Coptidis Rhizoma for the treatment of diabetes complications involved 184 Chinese medicinals， and the top 3 complications were diabetic nephropathy， diabetic peripheral neuropathy， and diabetic gastroenteropathy. The dose of Coptidis Rhizoma in the treatment of diabetes complications fell in the range of 2-15 g， and 10， 6， and 5 g were most frequently used.

Conclusion

Formulas containing Coptidis Rhizoma for the treatment of diabetes and its complications mainly target the syndrome of dampness-heat transforming into fire and the syndrome of excessive heat damaging yin. This study can serve as a reference for standard use of Coptidis Rhizoma in the prevention and treatment of diabetes and its complications.

关键词

黄连糖尿病数据挖掘用药规律中医传承计算平台（V3.0）

Keywords

Coptidis Rhizomadiabetesdata miningmedication rulesTraditional Chinese Medicine Inheritance Computing Platform （V3.0）

references

中华中医药学会.糖尿病中医防治指南［J］.中国中医药现代远程教育，2011，9（4）：148-151.

李敏谦，林育，项磊，等.瘅浊与糖脂代谢病［J］.世界中医药，2019，14（3）：652-655.

LIAN F，NI Q，SHEN Y，et al.International traditional Chinese medicine guideline for diagnostic and treatment principles of diabetes［J］.Ann Palliat Med，2020，9（4）：2237-2250.

王新征，李燕.黄连降糖作用机制的研究进展［J］.中医临床研究，2021，13（12）：125-127.

张青，李琰，陈磊.黄连素对2型糖尿病及其并发症的治疗作用及相关机制研究进展［J］.中国中药杂志，2015，40（9）：1660-1665.

史宇广，单书健.当代名医临证精华·消渴专辑［M］.北京：中医古籍出版社，1992：1-148.

单书健，陈子华.古今名医临证金鉴·消渴卷［M］.北京：中国中医药出版社，1999：1-308.

高彦彬.古今糖尿病医论医案选［M］.北京：人民军医出版社，2005：62-808.

沈元良.名老中医话糖尿病［M］.北京：金盾出版社，2013：1-292.

杨晓晖，董秀文.糖尿病医方1 000首［M］.北京：科学技术文献出版社，2002：1-390.

国家药典委员会.中华人民共和国药典：一部［M］.北京：中国医药科技出版社，2020.

仝小林.糖尿病中医药临床循证实践指南［M］.北京：科学出版社，2016：1-245.

卢朋，李健，唐仕欢，等.中医传承辅助系统软件开发与应用［J］.中国实验方剂学杂志，2012，18（9）：1-4.

方药中.实用中医内科学［M］.上海：上海科学技术出版社，1982：717.

刘继林，孟宪丽，刘咏松.古代中医用黄连治疗消渴的方药探讨［J］.四川中医，2010，28（4）：41-43.

仝小林，刘文科，徐国良，等.黄连治疗糖尿病的临床剂量及用药经验［J］.中医杂志，2011，52（18）：1604-1605.

YIN J，XING H，YE J.Efficacy of berberine in patients with type 2 diabetes mellitus［J］.Metabolism，2008，57（5）：712-717.

ZHAO M M，LU J，LI S，et al.Berberine is an insulin secretagogue targeting the KCNH6 potassium channel［J］.Nat Commun，2021，12（1）：5616.

庞国明，倪青，张芳.2型糖尿病病证结合诊疗指南［J］.中医杂志，2021，62（4）：361-368.

董振华，祝谌予.祝谌予治疗糖尿病经验举要［J］.中国医药学报，1993（1）：43-46.

冯建华.消酮汤治疗糖尿病酮症15例［J］.山东中医杂志，1990（6）：14-15.

仝小林.黄连为主药系列经方在糖尿病辨治中的运用［J］.中医杂志，2013，54（3）：209-211.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Medication Rules and Academic Experience of Professor WANG Xingkuan in Treatment of Chest Stuffiness and Pain Based on Data Mining

Analysis of Medication Rules of Coronary Heart Disease with Heart Failure of Qi Deficiency and Blood Stasis Syndrome Based on Literature Research

Analysis on Medication Rules of Traditional Chinese Medicine for Treatment of Diabetic Peripheral Neuropathy Based on Clinical Literature

Analysis on Medication Rules of National Medical Masters in Treatment of Stomachache

Medication Rules for Treating Psoriasis by Professor ZHONG Yi-ze Based on Data Mining

Related Author

WANG Ziyan

FAN Jinru

ZHANG Chao

SHE Ruining

LIU Chengxin

WEI Jiaming

GUO Zhihua

Li-jie QIAO

Related Institution

Hunan University of Chinese Medicine

The First Clinical Medical College， Henan University of Chinese Medicine

The First Affiliated Hospital of Henan University of Chinese Medicine

Xiyuan Clinical Medical College, Beijing University of Chinese Medicine

Beijing Key Laboratory of Pharmacology of Chinese Materia Medica,Institute of Basic Medical Sciences,Xiyuan Hospital,China Academy of Chinese Medical Sciences

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰