Effect and Mechanism of Modified Banxia Xiexintang on Depression During Perimenopause

Jia PAN; Qiang HU; Jun-jun YANG; Ben-yan SONG; Nan NING; Li HUANG; Jie LIU; Ya-ou LIU; Yan-li DENG; Ya YU; Li-min LI

doi:10.13422/j.cnki.syfjx.20192134

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Effect and Mechanism of Modified Banxia Xiexintang on Depression During Perimenopause

Classic Prescriptions | 更新时间：2021-02-09

- Effect and Mechanism of Modified Banxia Xiexintang on Depression During Perimenopause
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 3, Pages: 15-20(2020)
- 作者机构：
  
  1.四川省中医药科学院，成都　 610041
  2.攀枝花学院　附属医院，四川攀枝花　 617000
  3.四川省中西医结合医院，成都　 610024
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192134
  CLC： R289.3; R71; R711; 271.11
- Published：05 February 2020，
  
  Published Online：30 July 2019，
  
  Received：27 June 2019，
- 稿件说明：
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Jia PAN, Qiang HU, Jun-jun YANG, et al. Effect and Mechanism of Modified Banxia Xiexintang on Depression During Perimenopause. [J]. Chinese Journal of Experimental Traditional Medical Formulae 26(3):15-20(2020)
DOI：

Jia PAN, Qiang HU, Jun-jun YANG, et al. Effect and Mechanism of Modified Banxia Xiexintang on Depression During Perimenopause. [J]. Chinese Journal of Experimental Traditional Medical Formulae 26(3):15-20(2020) DOI： 10.13422/j.cnki.syfjx.20192134.

摘要

目的：

观察半夏泻心汤加减治疗围绝经期抑郁症的临床疗效及对5-羟色胺(5-HT)和促炎因子的影响。

方法：

将139例患者随机按数字表法分为对照组69例和观察组70例。对照组口服替勃龙片，2.5 mg/次，1次/d；口服盐酸帕罗西汀片，20 mg/次，1次/d。观察组西药治疗同对照组，并内服半夏泻心汤加减，1剂/d。两组疗程均为连续治疗8周。进行治疗前后汉密尔顿抑郁量表17项(HAMD-17)，Zung氏抑郁自评量表(SDS)，汉密尔顿焦虑量表(HAMA)，改良Kupperman(KI)，肝郁脾虚证和围绝经期综合征生活质量评定量表(MENQOL)评分；检测治疗前后5-HT，肿瘤坏死因子-

(TNF-

)，白细胞介素-1

(IL-1

)和脑源性神经营养因子(BDNF)，进行不良反应量表(TESS)评价。

结果：

治疗后观察组HAMD-17和SDS评分均低于对照组(

0.01)；观察组抑郁症疗效优于对照组(

＝2.074，

0.05)；观察组抑郁程度轻于对照组(

＝2.157，

0.05)；观察组患者的HAMA，KI和肝郁脾虚证评分均低于对照组(

0.01)；观察组围绝经期综合征严重程度轻于对照组(

＝2.046，

0.05)；观察组MENQOL量表血管舒缩症状和心理症状2个维度评分和总分均低于对照组(

0.05)；治疗后观察组5-HT高于对照组，BDNF高于对照组(

0.01)，TNF-

，IL-1

水平均低于对照组(

0.01)；观察组TESS评分低于对照组(

0.01)。

结论：

在常规西医治疗的基础上，加服半夏泻心汤加减能进一步改善抑郁、焦虑和围绝经期综合(PMS)症状，提高生活质量，并可抑制促炎因子，增强5-HT，BDNF表达，且无不良事件发生。

Abstract

Objective:

To observe the effect of modified Banxia Xiexintang on depression during perimenopause

in order to study itseffecton 5-hydroxytryptamine (5-HT) and proinflammatory factors.

Method:

One hundred and thirty-nine patients were randomly divided into control group (69 cases) and observation group (70 cases) by random number table.Patients in control group got tibolone tablets

2.5 mg/time

1 time/day

and paroxetine hydrochloride tablets

20 mg/time

1 time/day.In addition to the therapy in control group

patients in observation group were added with modified Banxia Xiexintang

1 dose/day.The course of treatment was 8 weeks.And before and after treatment

Hamilton depression scale for-17 items (HAMD-17)

Zung's self-rating depression scale (SDS)

hamilton anxiety scale (HAMA)

improvement Kupperman(KI)

liver depression and spleen deficiency syndrome

menopause-specific quality of life questionnaire (MENQOL) and treatment emergent symptom scale (TESS) were scored

and levels of 5-HT

rain-derived neurotrophic factor (BDNF)

interleukin-1

(IL-1

) and tumor necrosis factor-

(TNF-

) were detected.

Result:

After treatment

scores of HAMD-17 and SDS in observation group were lower than those in control group (

0.01). And the effect on trea depression in observation group was better than that in control group (

=2.074

0.05). The degree of depression in observation group was ligher than that in control group (

=2.157

0.05). And scores of HAMA

KI and liver depression and spleen deficiency syndrome were lower than those in control group (

0.01). The severity of perimenopausal syndrome was ligher than that in control group (

=2.046

0.05). And scores of vasomotor symptoms and psychological symptoms of MENQOL scale and the total scores were lower than those in control group (

0.05). Levels of 5-HT and BDNF were higher than those in control group (

0.01)

while levels of IL-1

TNF-

and TESS were lower than those in control group (

0.01).

Conclusion:

In addition to theroutine western medicine

modified Banxia Xiexintang can alleviate the severity of depression

release the symptoms of depression

anxiety and perimenopausal syudrome(PMS)

improve the quality of life

inhibit pro-inflammatory factors

and enhance the expressions of 5-HT and BDNF

with no adverse event.

关键词

围绝经期抑郁肝郁脾虚证半夏泻心汤生活质量5-羟色胺促炎因子

Keywords

perimenopausal depressionliver depression and spleen deficiency syndromeBanxia Xiexintangquality of life5-hydroxytryptamine(5-HT)pro-inflammatory factor

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