Effect of Modified Longdan Xiegantang in Treatment of Anal Sinusitis Patients with Syndrome of Interior Dampness-heat and on Immune Response, Oxidative Stress

Ning ZHANG; Xiao-li ZHOU; Shuai LIU

doi:10.13422/j.cnki.syfjx.20191624

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Effect of Modified Longdan Xiegantang in Treatment of Anal Sinusitis Patients with Syndrome of Interior Dampness-heat and on Immune Response, Oxidative Stress

Clinic | 更新时间：2021-02-09

- Effect of Modified Longdan Xiegantang in Treatment of Anal Sinusitis Patients with Syndrome of Interior Dampness-heat and on Immune Response, Oxidative Stress
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 3, Pages: 78-83(2020)
- 作者机构：
  
  1.河南省中医院，郑州　 450002
  2.河南中医药大学　第三附属医院，郑州　 450008
  3.郑州颐和医院，郑州 450046
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191624
  CLC： R22; R242; R2-031; R287
- Published：05 February 2020，
  
  Published Online：08 May 2019，
  
  Received：09 December 2018，
- 稿件说明：
扫描看全文
Ning ZHANG, Xiao-li ZHOU, Shuai LIU. Effect of Modified Longdan Xiegantang in Treatment of Anal Sinusitis Patients with Syndrome of Interior Dampness-heat and on Immune Response, Oxidative Stress. [J]. Chinese Journal of Experimental Traditional Medical Formulae 26(3):78-83(2020)
DOI：

Ning ZHANG, Xiao-li ZHOU, Shuai LIU. Effect of Modified Longdan Xiegantang in Treatment of Anal Sinusitis Patients with Syndrome of Interior Dampness-heat and on Immune Response, Oxidative Stress. [J]. Chinese Journal of Experimental Traditional Medical Formulae 26(3):78-83(2020) DOI： 10.13422/j.cnki.syfjx.20191624.

摘要

目的：

探究龙胆泻肝汤加减治疗肛窦炎(anal cryptitis，AC)湿热内蕴证的疗效及对免疫应答、氧化应激的影响。

方法：

随机将2017年5月至2018年5月河南省中医院收治的80例湿热内蕴证型AC患者分为对照组和观察组，各40例，对照组采用甲硝唑注射液联合硫酸庆大霉素注射液灌肠治疗，并给予生物刺激反馈仪治疗，在对照组的基础上，治疗组给予龙胆泻肝汤加减水煎服。治疗前后观察两组的症状体征评分，白细胞介素-2(interleukin-2，IL-2)，IL-4，IL-6，IL-10，肿瘤坏死因子-

(tumor necrosis factor-

，TNF-

)，

-干扰素(interferon-

，IFN-

)，降钙素原(procalcitonin，PCT)，CD3

＋

，CD4

＋

，CD8

＋

，免疫球蛋白A (immunoglobulin A，IgA)，IgG，IgM，IgE，超氧化物歧化酶(superoxide dismutated alcohol，SOD)，丙二醛(malonaldehyde，MDA)，并观察两组的疗效、不良反应及复发情况。

结果：

经秩和检验，治疗组临床疗效明显优于对照组(

＝1.981，

0.05)。治疗组治疗后肛门坠胀、疼痛等症状评分及肛窦触痛、充血、水肿等体征评分低于对照组(

0.05)。治疗组治疗后TNF-

，PCT，IL-2，IL-6，MDA水平低于对照组(

0.05)，治疗组治疗后IL-4，IL-10，IFN-

，SOD水平高于对照组(

0.05)。治疗组复发率为5.13%，对照组复发率为21.05%，治疗组低于对照组(

＝4.319，

0.05)。

结论：

龙胆泻肝汤加减治疗湿热内蕴证AC的疗效较好，能有效地缓解症状，调节促炎/抗炎平衡和Th1/Th2平衡，改善细胞免疫功能和体液免疫功能，抑制氧化应激反应，降低复发率，安全性高。

Abstract

Objective:

To explore the effect of modified Longdan Xiegantang in treatment of anal sinusitis patients with syndrome of interior dampness-heat and on immune response

oxidative stress.

Method:

A total of 80 cases of anal sinusitis patients with syndrome of interior dampness-heat treated in our hospital from May 2017 to May 2018 were randomly divided into two groups

with 40 cases in each group. The control group was treated by enema with Metronidazole injection combined with gentamicin sulfate injection. In addition to the therapy of the control group

the treatment group was also given modified Longdan Xiegantang. The symptoms and signs score

interleukin (IL)-2

IL-4

IL-6

IL-10

tumor necrosis factor-

(TNF-

)

interferon-

(IFN-

)

procalcitonin (PCT)

CD3

CD4

CD8

immunoglobulin A(IgA)

IgG

IgM

IgE

SOD

propylene glycol (MDA) levels of two groups were observed before and after treatment

and the curative effect

reactions and relapse were observed.

Result:

The clinical efficacy of treatment group was significantly better than that of control group

and the rank-sum test showed statistically significant differences (Z=1.981

0.05). After treatment

the scores of symptoms

such as anal distension and pain

and signs

such as anal sinus tenderness

hyperemia and edema in the treatment group were lower than those in control group (

0.05). The levels of TNF-

PCT

IL-2

IL-6 and MDA in treatment group were lower than those in control group (

0.05). The levels of IL-4

IL-10

IFN-

and SOD in treatment group were higher than those in control group (

0.05). The recurrence rate was 5.13%in treatment group

and 21.05%in control group

indicating a significant difference (

=4.319

0.05).

Conclusion:

Modified Longdan Xiegantang is effective in treating syndrome of interior dampness-heat anal sinusitis. It can effectively relieve symptoms

regulate pro-inflammatory/anti-inflammatory balance and Th1/Th2 balance

improve cellular immune function and humoral immune function

inhibit oxidative stress response

and reduce recurrence rate

with a high safety.

关键词

肛窦炎龙胆泻肝汤加减炎症氧化应激免疫功能

Keywords

anus sinusitismodified Longdan Xiegantanginflammationoxidative stressimmune function

references

C YANG, X CHEN, Z WEI, et al. Targeting the class IA PI3K isoforms p110α/δ attenuates heart allograft rejection in mice by suppressing the CD4＋ T lymphocyte response[J].Am J Transl Res，2018，10(5)：1387-1399.

H L Kim, M Y Lee, S Y Park, et al. Comparative effectiveness of cycling of tumor necrosis fator-α (TNF-α) inhibitors versus switching to non-TNF biologics in rheumatoid arthritis patients with inadequate response to TNF-α inhibitor using a Bayesian appro[J].Arch Pharm Res，2014，37(5)：662-670.

王小林，耿学斯．肛窦炎的中医药治疗进展[J]．云南中医中药杂志，2014，35(1)：64-65.

杜炳林，钟馨，张燕生，等．张燕生教授从中医外科角度辨治肛窦炎[J]．中医药学报，2017，45(1)：70-72.

王成江．中医治疗肛窦炎的临床探析[J]．中国卫生标准管理，2015，6(11)：121-122.

陈笑吟，孙婉瑾，金实，等．加味苦参汤治疗肛窦炎湿热下注证临床研究[J]．中医学报，2017，32(7)：1187-1191.

蒋尚玲，史冰花，吴志均，等．肛窦炎的非手术治疗进展[J]．实用中西医结合临床，2016，16(6)：84-85.

吴云翔，陈光华，张磊昌，等．白头翁汤方加味结合肛肠内腔治疗仪治疗肛窦炎患者的疗效及其对炎性因子水平的影响[J]．抗感染药学，2018，15(9)：1501-1503.

李克亚，王真权，肖超．止痛如神汤保留灌肠治疗湿热下注型肛窦炎40例临床观察[J]．中医药导报，2015，21(10)：76-78.

张鑫龙，石健，武岳，等．复方黄柏液涂剂保留灌肠治疗湿热下注型肛窦炎临床观察[J]．安徽中医药大学学报，2018，37(5)：11-14.

安阿玥．肛肠病学[M]．北京：人民卫生出版社，2005：250.

何永恒，凌光烈．中医肛肠科学[M]．北京：清华大学出版社，2011：146-147.

陈波，张晟，王秋平，等．参柏汤保留灌肠联合生物刺激反馈仪治疗湿热下注型肛窦炎的临床研究[J]．世界中西医结合杂志，2018，13(4)：514-516，520.

国家中医药管理局．中医病证诊断疗效标准[M]．北京：中国医药科技出版社，2012：54.

中华人民共和国卫生部．中药新药临床研究指导原则[M]．北京：中国医药科技出版社，2002: 181-182.

王建国，刘声，刘青云，等．急性肛周感染患者的免疫应答与炎症反应[J]．中国中西医结合外科杂志，2017，23(5)：534-537.

程东红，杜宇鹏，王超．苦参清湿液保留灌肠治疗肛窦炎的临床观察[J]．临床医药文献电子杂志，2018，5(14)：136-137.

李金元．加味苦参汤联合保留灌肠治疗肛窦炎的临床观察[J]．江西中医药，2018，49(3)：49-51.

张承国．中药保留灌肠与穴位埋线、龈交穴挑刺联合治疗慢性肛窦炎的疗效观察[J]．中国现代药物应用，2018，12(12)：117-119.

H LIANG, X YANG, C LIU, et al. Effect of NF-κB signaling pathway on the expression of MIF, TNF-α，IL-6 in the regulation of intervertebral disc degeneration[J].J Musculoskelet Neuronal Interact，2018，18(4)：551-556.

刘丹，刘旭，姜燕．金叶败毒颗粒联合头孢呋辛钠治疗急性上呼吸道感染的临床研究[J]．现代药物与临床，2018，33(11)：2876-2879.

余文美，王建民．基于血清IL-6、IFN-γ观察脉络疏通丸治疗湿热壅滞型混合痔术后水肿的临床疗效[J]．江西中医药大学学报，2019，31(1)：34-36.

张石宇，刘文，郭光伟，等．葛根芩连结肠定位片对湿热内蕴型溃疡性结肠炎家兔模型Th1/Th2细胞因子平衡的影响[J]．时珍国医国药，2016，27(10)：2387-2391.

王丹，赵瑞珍，曲淼，等．补益心脾对产后抑郁症大鼠模型Th1/Th2平衡细胞免疫调节作用的影响[J]．世界中医药，2018，13(11)：2823-2828.

杨莉平，欧阳瑶．DCs、Th1及Th2细胞在COPD免疫机制中的作用研究[J]．医学综述，2018，29(22)：4427-4432.

常利兼，杨小琼，刘春凤．AECOPD患者营养及氧化应激状态与其病情程度的相关性研究[J]．临床肺科杂志，2018，23(12)：2196-2199.

许志有，符艺影，韩萍，等．调节性T细胞平衡相关因子在儿童紫癜性肾炎中的表达及其与血清中期因子的相关性[J]．免疫学杂志，2018，34(12)：1071-1076.

边红恩，陈团营，单海军．加味五虎汤联合阿奇霉素治疗痰热闭肺型小儿支原体肺炎疗效及对T淋巴细胞亚群的影响[J]．中国实验方剂学杂志，2018，24(2)：164-169.

傅永锦，张小牧，连大卫，等．肠炎清对溃疡性结肠炎模型大鼠中分泌型免疫球蛋白A和P选择素的影响[J]．中国实验方剂学杂志，2014，20(3)：148-152.

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