Review of 3D Printing Technology in Development and Application of Innovative Chinese Medicines

Chang-qing LIU; Hai-xia WANG; Zheng LI; Xin-bo SONG; Ping WANG

doi:10.13422/j.cnki.syfjx.20191947

您当前的位置：

首页 >

文章列表页 >

Review of 3D Printing Technology in Development and Application of Innovative Chinese Medicines

Review | 更新时间：2021-02-09

- Review of 3D Printing Technology in Development and Application of Innovative Chinese Medicines
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 3, Pages: 236-242(2020)
- 作者机构：
  
  1.天津中医药大学　中药制药工程学院，天津　 301617
  2.天津现代创新中药科技有限公司，天津　 300392
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191947
  CLC： R22; R28; R94; TQ460; TP334.8
- Published：05 February 2020，
  
  Published Online：19 June 2019，
  
  Received：01 June 2019，
- 稿件说明：
扫描看全文
Chang-qing LIU, Hai-xia WANG, Zheng LI, et al. Review of 3D Printing Technology in Development and Application of Innovative Chinese Medicines. [J]. Chinese Journal of Experimental Traditional Medical Formulae 26(3):236-242(2020)
DOI：

Chang-qing LIU, Hai-xia WANG, Zheng LI, et al. Review of 3D Printing Technology in Development and Application of Innovative Chinese Medicines. [J]. Chinese Journal of Experimental Traditional Medical Formulae 26(3):236-242(2020) DOI： 10.13422/j.cnki.syfjx.20191947.

摘要

3D打印技术是一种有效的增材制造技术，在航天、建筑、机械制造等领域应用较为成熟，但是在制药领域，尤其是中药制药领域应用还很少。2015年，首例3D打印药物左乙拉西坦(Spritam)速溶片的上市极大地推动了3D打印技术在制药行业的研究应用。该文就与制药行业应用匹配度较高的三类3D打印机(粘结剂喷射式、材料挤压式和喷墨打印式)进行介绍，包括这三类打印机的工作原理、打印材料及产品特性等方面。并就3D打印技术在中药创新制剂生产、创新医疗器械开发及创新功能食品研制方面的应用前景及存在问题展开分析，以期为创新中药的研制提供有益借鉴。

Abstract

As an effective additive manufacturing technology

3D printing technology has been widely used in aerospace

construction

machinery manufacturing and other fields

but it is rarely used in the pharmaceutical field

especially in the field of traditional Chinese medicine (TCM). In 2015

Spritam instant tablets produced by 3D printing technology greatly promoted the development and research of 3D printing technology in the pharmaceutical industry. In this paper

we reviewed three types of 3D printers (binder jet

material extrusion and inkjet printing) with high compatibility in the pharmaceutical industry

including the working principles

printing materials

product characteristics and others. In addition

the application prospects and existing problems of 3D printing technology in the production of innovative preparations of TCM

the development of innovative medical devices and the development of innovative functional foods were analyzed. The paper aimed to provide a reference for the development and preparation of innovative TCM by 3D printing technology.

关键词

3D打印创新中药制药行业个性化治疗中医药现代化缓控释制剂功能食品

Keywords

3D printinginnovative Chinese medicinespharmaceutical industrypersonalized treatmentmodernization of traditional Chinese medicinesustained and controlled release preparationfunctional food

references

J G ZHOU，D Herscovici，C C CHEN．Parametric process optimization to improve the accuracy of rapid prototyped stereolithography parts[J]．Int J Mach Tool Manu，2000，40(3)：363-379.

W E Katstra，R D Palazzolo，C W Rowe，et al.Oral dosage forms fabricated by three dimensional printing[J]．J Control Release，2000，66(1)：1-9.

A Goyanes，H CHANG，D Sedough，et al.Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing[J]．Int J Pharm，2015，496(2)：414-420.

刘波．基于ARM的激光烧结型3D打印机控制系统研究[D]．济南：山东理工大学，2018.

J F XING，M L ZHENG，X M DUAN．Two-photon polymerization microfabrication of hydrogels：an advanced 3D printing technology for tissue engineering and drug delivery[J]．Chem Soc Rev，2015，44(15)：5031-5039.

N Genina，D Fors，H Vakili，et al.Tailoring controlled-release oral dosage forms by combining inkjet and flexographic printing techniques[J]．Eur J Pharm Sci，2012，47(3)：615-623.

林启凤，杨帆，范凯燕，等.3D打印速效救心口崩片的制备研究[J]．广东药学院学报，2016，32(1)：1-4.

S A Khaled，M R Alexander，D J Irvine，et al.Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry[J]．AAPS Pharm Sci Tech，2018，19(8)：3403-3413.

王运赣，王宣.3D打印技术[M]．武汉：华中科技大学出版社，2014：68-83.

E A Clark，M R Alexander，D J Irvine，et al.3D printing of tablets using inkjet with UV photoinitiation[J]．Int J Pharm，2017，529(1/2)：523-530.

M Kyobula，A Adedeji，M R Alexander，et al.3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release[J]．J Control Release，2017，261：207-215.

S T WU，J S LI，J MAI，et al.3D electrohydrodynamic printing and spinning of flexible composite structures for oral multi-drug forms[J]．ACS Appl Mater Inter，2018，10(29)：24876-24885.

J X YAN，Y WANG，X ZHANG，et al.Snakegourd root/Astragalus polysaccharide hydrogel preparation and application in 3D printing[J]．Int J Biol Macromol，2019，doi：10.1016/j.ijbiomac.2018.10.008http://dx.doi.org/10.1016/j.ijbiomac.2018.10.008.

沈卫东，周媛．基于3D打印的耳窍给药器及其打印方法：中国，CN107981973A[P].2018-01-25.

国大亮，张秀君，张世川.3D打印制药虚拟仿真实验教学平台建设的探索[J]．药学研究，2018，37(8)：487-489.

P WANG，G LI，W QIN，et al.Repair of osteonecrosis of the femoral head[J]．Der Orthopäde，2019，48(3)：213-223.

C H Yeh，Y W CHEN，M Y Shie，et al.Poly(dopamine)-assisted immobilization of Xu Duan on 3D printed poly(lactic acid) scaffolds to up-regulate osteogenic and angiogenic markers of bone marrow stem cells[J]．Materials(Basel)，2015，8(7)：4299-4315.

黄彬洋，刘晓瑞，王小青，等．一种基于3D打印的中药一体式鞋垫：中国，CN207531979U[P].2018-06-26.

D Periard，N Schaal，M Schaal，et al.Printing food：report of Cornell university[R]．Louisville：Cornell University，2007.

肖俊勇，占密勤，从仁怀，等．含中药功能因子巧克力3D打印成型性研究[J]．食品工业科技，2019，40(5)：77-82.

万江陵，万影，岑培倩，等．一种可选载复合多糖的凝胶软糖3D打印料及其制备方法：中国，CN108402264A[P].2018-08-17.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Application and Prospect Analysis of Preparation Technology in Improving Antibacterial Activity of Traditional Chinese Medicine

Related Author

Chen CHEN

Yong-yuan LI

Hai-xia WANG

Ze-shuai ZHANG

Zheng LI

Tong-chuan SUO

Xin-bo SONG

Ping WANG

Related Institution

College of Pharmaceutical Engineering of Traditional Chinese Medicine （TCM）， Tianjin University of TCM

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰