Advances in Chemical Constituents and Bioactivities of Macleaya cordata

Wei CHEN; Rui ZHANG; Si-min LEI; Huai-long ZUO; Shi-ji CHEN; Yao-dong CHANG

doi:10.13422/j.cnki.syfjx.20200113

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Advances in Chemical Constituents and Bioactivities of Macleaya cordata

Review | 更新时间：2021-02-09

- Advances in Chemical Constituents and Bioactivities of Macleaya cordata
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 3, Pages: 243-250(2020)
- 作者机构：
  
  西南交通大学　生命科学与工程学院，成都 610031
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20200113
  CLC： R289; R284.1; R22; R2-031
- Published：05 February 2020，
  
  Published Online：18 September 2019，
  
  Received：09 June 2019，
- 稿件说明：
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Wei CHEN, Rui ZHANG, Si-min LEI, et al. Advances in Chemical Constituents and Bioactivities of Macleaya cordata. [J]. Chinese Journal of Experimental Traditional Medical Formulae 26(3):243-250(2020)
DOI：

Wei CHEN, Rui ZHANG, Si-min LEI, et al. Advances in Chemical Constituents and Bioactivities of Macleaya cordata. [J]. Chinese Journal of Experimental Traditional Medical Formulae 26(3):243-250(2020) DOI： 10.13422/j.cnki.syfjx.20200113.

摘要

博落回是罂粟科博落回属多年生直立草本植物，味苦，辛，性寒，温，大毒，广泛分布于我国长江以南、南岭以北的大部分省区，文献记载其具有悠久的药用历史。文献记载其具有祛风镇痛、解毒消肿等功用，主要治疗毒脓肿、恶疮溃疡、疥癣、滴虫性阴道炎等；亦有杀虫、止痒之功效。博落回的主要化学成分为异喹啉生物碱，其中血根碱、白屈菜红碱、原阿片碱和别隐品碱含量较高。此外，还含有苯丙素类、甾体类、有机酸类、酚类和挥发油等。博落回的药理作用主要为具抗菌、抗炎、抗肿瘤和改善肝功能等。在农业上可作为植物源杀虫剂和抑菌剂，也可当作饲料添加剂用于畜牧业。近年来，有大量关于博落回的文献报道，尤其是单体化合物的分离鉴定和活性研究。该文通过查阅国内外文献，对博落回的化学成分及其药理作用进行了系统总结，为博落回提取物及其单体化合物的开发利用提供理论依据。

Abstract

Macleaya corda

a perennial plant in the genus

Macleaya

it mainly distributed in most provinces and regions south of the Yangtze river and north of Nanling mountains of China and has been used as a Chinese traditional medicine. It is bitter

cold

warm

poisonous.

corda

ta has the functions of dispelling wind

analgesia

detoxification and detumescence. It mainly treats poisonous abscess

cachexia

ulcer

scabies

trichomonal vaginitis

etc. It also has insecticidal and anti-itching activities. The main chemical constituents of

cordata

are isoquinoline alkaloids

sanguinarine

chelerythrine

protoopioid and allocrine alkaloids are the higher ones. In addition

it also contains phenylpropanoids

steroids

organic acids

phenols and volatile oils. The pharmacological effects of

cordata

are mainly anti-bacterial

anti-inflammatory

anti-tumor and improving liver function. In agriculture

it can be used as botanical insecticides and bacteriostasis

and also as feed additives for animal husbandry. By reviewing and analyzing domestic and foreign researches that isoquinolines were the main active constituents and characteristic components of

cordata

. This paper provides theoretical basis for the development and utilization of

cordata

extract and its' monomer compounds.

关键词

博落回化学成分药理作用异喹啉生物碱

Keywords

Macleaya cordatachemical constituentspharmacological effectsisoquinolines

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