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1.湖南中医药大学,长沙 410208
2.遵义市播州区中医院,贵州 遵义 563100
3.昆明市中医医院,昆明 650500
Published:05 March 2021,
Published Online:16 November 2020,
Received:30 July 2020,
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易腾达,李玉丽,牛林强等.经典名方开心散及类方的古代文献考证[J].中国实验方剂学杂志,2021,27(05):8-15.
YI Teng-da,LI Yu-li,NIU Lin-qiang,et al.Textual Research on Ancient Literature of Classical Prescription Kaixinsan and Its Associated Prescription[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(05):8-15.
易腾达,李玉丽,牛林强等.经典名方开心散及类方的古代文献考证[J].中国实验方剂学杂志,2021,27(05):8-15. DOI: 10.13422/j.cnki.syfjx.20210114.
YI Teng-da,LI Yu-li,NIU Lin-qiang,et al.Textual Research on Ancient Literature of Classical Prescription Kaixinsan and Its Associated Prescription[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(05):8-15. DOI: 10.13422/j.cnki.syfjx.20210114.
经典名方开心散载于《备急千金要方》,是古代医家治疗健忘的名方之一。经典名方的研究已越来越受到研究机构和相关企业的重视,从古籍出发,考证方剂的源流,梳理主治衍变规律,制剂,服法,禁忌等内容是研究经典名方的重要内容。考证结果表明,《备急千金要方》开心散的创制可追溯至《集验方》开心散和《古今录验方》定志丸。后世医家在应用开心散的过程中创制了许多类方,主治病证也有了拓展,在唐、宋时期,开心散及其类方的主治主要为喜忘、忧愁悲伤、惊悸恐怯等病证。金、元时期,增加了动风抽搐、呵欠等病证。发展至明代,主治拓展了远视、近视、遗精、便浊等证。到了清代,主治又拓展了耳目不聪、年老神衰和汗症。在治疗“目不能近视,反能远视”、遗精、便浊时,古人多重用人参、茯苓;治疗“目能近视,不能远视”重用远志、菖蒲。其主治病机总结为心脾两虚,心肾不交,痰湿内阻。通过总结开心散类方的制剂内容,建议开心散中药复方制剂的剂型可为丸剂,规格大小可遵循古人之“梧桐子大”,单颗药丸体积约0.25 mL,质量约0.3 g;单次服用起始剂量为15丸,随病情轻重予以加减,以每次“不过四十丸”为度,每日3次。服药期间应忌酸、甜、羊肉等刺激性食物。以上结果可为开心散中药复方制剂的开发提供文献依据。
The classical prescription Kaixinsan,which is recorded in an ancient medical book named
Beiji Qianjin Yaofang
,is one of the famous prescriptions used by ancient physicians to treat amnesia. Research on classical prescriptions has attracted more and more attention from scientific research institutions and related enterprises. Based on ancient books,textual research on origins and development of prescriptions,combing the evolution of prescriptions,preparations,oral ways,taboos and others are the important contents of the study on classical prescriptions. The research results show that the creation of Kaixinsan in
Beiji Qianjin Yaofang
can be traced back to Kaixinsan recorded in
Jiyanfang
and Dingzhiwan recorded in
Gujinluyanfang
. Later generations of physicians created many associated prescriptions in the process of applying Kaixinsan,and the efficacy of these prescriptions was constantly expanded with the development of the times. In the Tang and Song dynasties,Kaixinsan and its associated prescriptions were mainly used to treat amnesia,sorrow,fear,and other diseases. In the Jin and Yuan dynasties,these prescriptions were also used to treat convulsions and yawning. In the Ming dynasty, they were mainly for the treatment of hyperopia, myopia, sprematorrhea,and constipation. In the Qing dynasty,these herbs could be used to treat auricular deafness, aging and sweating. The dosage of Ginseng Radix et Rhizoma and Poria should be increased in the treatment of farsightedness,spermatorrhea and blurred urine,and in the treatment of nearsightedness,the dosage of Polygalae Radix and Haliotidis Concha should be increased. The main pathogenesis of the disease that Kaixinsan and its associated prescriptions treated could be summarized as the deficiency of heart and spleen,imbalance between heart-Yang and kidney-Yin,and the internal resistance of phlegm stagnation. By summarizing the contents of the preparation of tradition Chinese medicine products for Kaixinsan and its associated prescriptions,it is suggested that the dosage form of Kaixinsan can be pills,with the specification size confroming to the most record of ancient generations of physicians,as big as
Firmiana platanifolia
's fruit.The volume of a single pill is about 0.25 mL and the weight is about 0.3 g. The initial dosage is fifteen pills,which can be modified according to the severity of the illness,with no more than forty pills for each time,three times a day. Also,some excitant food like the sour food,sweet food and mutton should be avoided during the medication. The above research results can provide literature basis for the development of compound tradition Chinese Medicine preparation of Kaixinsan.
经典名方开心散类方复方制剂文献研究
famous classical formulasKaixinsanassociated prescriptionscompound preparationtextual research
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