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Research Progress of Quercetin in Treatment of Rheumatoid Arthritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 27, Issue 5, Pages: 243-250(2021)
- 作者机构：
北京中医药大学 生命科学学院，北京 100029
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20210105
CLC： R2-0;R22;R285.5;R284Published：05 March 2021，
Published Online：06 January 2021，
Received：13 January 2020，
- 稿件说明：
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蒋海旭,许杰,陆清怡.槲皮素治疗类风湿关节炎的研究进展[J].中国实验方剂学杂志,2021,27(05):243-250.
JIANG Hai-xu,XU Jie,LU Qing-yi.Research Progress of Quercetin in Treatment of Rheumatoid Arthritis[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(05):243-250.
蒋海旭,许杰,陆清怡.槲皮素治疗类风湿关节炎的研究进展[J].中国实验方剂学杂志,2021,27(05):243-250. DOI： 10.13422/j.cnki.syfjx.20210105.
JIANG Hai-xu,XU Jie,LU Qing-yi.Research Progress of Quercetin in Treatment of Rheumatoid Arthritis[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(05):243-250. DOI： 10.13422/j.cnki.syfjx.20210105.
摘要
类风湿关节炎（RA）是一种以侵袭性、对称性多关节炎为主要临床表现的慢性、全身性自身免疫性疾病。确切的发病机制不明，基本的病理改变为关节滑膜慢性炎症、关节腔积液增多、血管翳形成，并逐渐出现软骨损伤和骨侵蚀，最终导致关节畸形和功能丧失。其起病和发展与遗传、环境等多种因素相关。RA主要治疗药物包括非甾体抗炎药（NSAIDs），皮质类固醇，改善病情抗风湿病药（DMARDs）和生物制剂等，但是长期服用这些药物会导致多种不良反应，如心肌梗死、消化性溃疡、伤口愈合不良、肝肾功能不全等。此外，天然药物以其广泛的药理活性和较小的不良反应具有良好的应用前景。槲皮素是一种存在于桑寄生、防己等中药中的黄酮类物质，具有多种药理活性，涉及心血管、关节运动、肿瘤免疫等。临床试验中槲皮素对RA疗效良好。实验研究表明，槲皮素可通过减轻炎症反应、抑制滑膜血管翳的形成、抑制滑膜增生、抑制中性粒细胞外诱捕网（NETs）的形成、抑制破骨细胞的作用、调节T细胞亚群辅助性T细胞17（Th17）/调节性T细胞（Treg）平衡等机制来改善RA。本文将简要概括槲皮素的药理活性，并详细论述槲皮素治疗类风湿关节炎可能的作用机制。
Abstract
Rheumatoid arthritis （RA） is a chronic and systemic autoimmune disease with aggressive and symmetrical polyarthritis as the main clinical manifestations. The exact pathogenesis is unknown. Its basic pathological changes include chronic inflammation of the joint synovium， increased joint cavity effusion， pannus formation， gradual cartilage damage and bone erosion， eventually leading to joint deformity and loss of function. It has been found that the onset and development of RA are related to heredity， environment and other factors. The drugs for RA mainly include non-steroidal anti-inflammatory drugs （NSAIDs）， corticosteroids， disease-modifying anti-rheumatic drugs （DMARDs） and biological agents. However， long-term use of these drugs can cause a variety of side effects and adverse reactions， such as myocardial infarction， peptic ulcer， poor wound healing， and liver and kidney dysfunction. In addition， natural medicines have a good application prospect because of their various pharmacological activities and few side effects. Quercetin is a flavonoid found in
Morus alba
and tetrandrine， with diverse pharmacological activities， including cardiovascular diseases， joint movement， tumor immunology and so on. Not only have the clinical trials shown good efficacy of quercetin， but the experimental studies have also proven that quercetin can improve RA by reducing inflammatory response， inhibiting the formation of synovial pannus， synovial hyperplasia， neutrophil NETs formation， osteoclast function， regulating Th17/Treg balance and other mechanism. In this article， we will briefly summarize the regulatory mechanism of quercetin and discuss the complexed effect of quercetin on rheumatoid arthritis.
关键词
类风湿关节炎槲皮素药理活性综述
Keywords
rheumatoid arthritisquercetinpharmacological activityreview
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