Pseudoallergic Reactions of Xuebijing Injection and Its Rational Drug Use

Yan YI; Chun-ying LI; Yu-shi ZHANG; Yong ZHAO; Gui-ping ZHANG; Jia-yin HAN; Jing-zhuo TIAN; Lian-mei WANG; Chen PAN; Su-yan LIU; Ai-hua LIANG

doi:10.13422/j.cnki.syfjx.20212522

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Pseudoallergic Reactions of Xuebijing Injection and Its Rational Drug Use

Pharmacology | 更新时间：2021-02-09

- Pseudoallergic Reactions of Xuebijing Injection and Its Rational Drug Use
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 27, Issue 5, Pages: 77-83(2021)
- 作者机构：
  
  1.中国中医科学院中药研究所，中药鉴定与安全性检测评估北京市重点实验室，创新天然药物与中药注射剂国家重点实验室，北京 100700
  2.天津红日药业股份有限公司，天津 301700
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20212522
  CLC： R22;R242;R2-031;R285.5
- Published：05 March 2021，
  
  Published Online：06 November 2020，
  
  Received：07 July 2020，
- 稿件说明：
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易艳,李春英,张宇实等.血必净注射液类过敏反应及合理用药方法[J].中国实验方剂学杂志,2021,27(05):77-83.

YI Yan,LI Chun-ying,ZHANG Yu-shi,et al.Pseudoallergic Reactions of Xuebijing Injection and Its Rational Drug Use[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(05):77-83.
易艳,李春英,张宇实等.血必净注射液类过敏反应及合理用药方法[J].中国实验方剂学杂志,2021,27(05):77-83. DOI： 10.13422/j.cnki.syfjx.20212522.

YI Yan,LI Chun-ying,ZHANG Yu-shi,et al.Pseudoallergic Reactions of Xuebijing Injection and Its Rational Drug Use[J].Chinese Journal of Experimental Traditional Medical Formulae,2021,27(05):77-83. DOI： 10.13422/j.cnki.syfjx.20212522.

摘要

目的

探讨血必净注射液（XBJJ）不良反应是否以类过敏反应为主，并挖掘其可能引起类过敏反应的影响因素。

方法

借助小鼠类过敏反应模型，分别选取XBJJ临床最高浓度的0.5，1，2倍进行类过敏反应研究，以判断不同浓度XBJJ是否诱发小鼠类过敏反应；比较配制后存放不同时间的XBJJ诱发小鼠类过敏反应是否存在差异，具体为配制XBJJ到不同浓度后，分别存放10 min，2.5 h，6 h，24 h后再给小鼠尾静脉注射；最后取选3 s，45 s，90 s 3个推注时间进行XBJJ注射，再对不同注射速度的XBJJ诱发小鼠类过敏反应差异进行比较。

结果

XBJJ在药物浓度高于临床推荐浓度时会诱发小鼠类过敏反应；与配制后存放10 min比较，随着存放时间的延长，相同浓度XBJJ诱发小鼠类过敏反应的程度加重；另外，当XBJJ以3 s注射完时（注射速度达0.083 mL·s

-1

)，其产生的类过敏反应最强。

结论

XBJJ诱发的不良反应以类过敏反应为主。XBJJ配制后存放时间过长和注射速度过快，都会导致其诱发小鼠类过敏反应加重。XBJJ临床使用时，应严格按照药品使用说明书推荐的用法、用量、配制浓度、滴注速度，并现用现配，合理用药，对于提高XBJJ的用药安全性具有积极意义。

Abstract

Objective

To investigate whether the adverse reactions of Xuebijing injection (XBJJ) are mainly pseudoallergic reactions and explore the influencing factors of its pseudoallergic reactions.

Method

Mouse model of pseudoallergic reaction was used to study the anaphylactoid reaction of XBJJ which at 0.5

1 and 2 times of the highest clinical concentration. Next

we compared the differences in pseudoallergic reactions caused by XBJJ for different storage times after preparation. Specifically

XBJJ was prepared into different concentrations

stored for 10 minutes

2.5 hours

6 hours and 24 hours

and then injected into the tail vein of mice. Finally

three different injection speeds of 3 seconds

45 seconds and 90 seconds were selected for XBJJ injection

and then the differences in the paeudoallergic reactions induced by XBJJ in mice under different injection speeds were compared.

Result

XBJJ induces pseudoallergic reactions in mice when the drug concentration is higher than the clinically recommended concentration. Compared with storage for 10 minutes after preparation

the degree of pseudoallergic reaction in mice induced by the same concentration of XBJJ increased with the extension of storage time. In addition

when XBJJ was injected in 3 s (the injection rate was 0.083 mL·s

-1

)

it produced the strongest pseudoallergic reaction.

Conclusion

The adverse reactions induced by XBJJ are mainly pseudoallergic reactions. Excessive storage time after preparation and fast injection speed of XBJJ will lead to aggravation of pseudoallergic reactions in mice. When XBJJ is used clinically

it should strictly follow the usage

dosage

concentration

and drip rate recommended in the drug instruction manual. Rational drug use is of positive significance for improving the safety of XBJJ.

关键词

血必净注射液不良反应类过敏反应合理用药

Keywords

Xuebijing injectionadverse reactionpseudoallergic reactionrational administration of drug

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