Effect of Modified Danggui Shaoyao San on MMP-2, ICAM-1, Emorheology and Inflammation in Patients with Chronic Pelvic Inflammatory Disease

Bao-qin YANG; Xian LI; Ling-ling LI

doi:10.13422/j.cnki.syfjx.20191623

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Effect of Modified Danggui Shaoyao San on MMP-2, ICAM-1, Emorheology and Inflammation in Patients with Chronic Pelvic Inflammatory Disease

Clinic | 更新时间：2021-02-09

- Effect of Modified Danggui Shaoyao San on MMP-2, ICAM-1, Emorheology and Inflammation in Patients with Chronic Pelvic Inflammatory Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 21, Pages: 72-77(2019)
- 作者机构：
  
  1.河南省中医院，郑州　 450002；
  2.河南中医药大学　第一附属医院，郑州　 450008
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191623
  CLC： R22; R242; R2-031; R287
- Published：05 November 2019，
  
  Published Online：06 May 2019，
  
  Received：04 December 2018，
- 稿件说明：
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Bao-qin YANG, Xian LI, Ling-ling LI. Effect of Modified Danggui Shaoyao San on MMP-2, ICAM-1, Emorheology and Inflammation in Patients with Chronic Pelvic Inflammatory Disease. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(21):72-77(2019)
DOI：

Bao-qin YANG, Xian LI, Ling-ling LI. Effect of Modified Danggui Shaoyao San on MMP-2, ICAM-1, Emorheology and Inflammation in Patients with Chronic Pelvic Inflammatory Disease. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(21):72-77(2019) DOI： 10.13422/j.cnki.syfjx.20191623.

摘要

目的：

观察加味当归芍药散对慢性盆腔炎(CPID)患者基质金属蛋白酶-2(MMP-2)，细胞间黏附分子-1(ICAM-1)，血液流变学及炎症的影响。

方法：

随机将2017年5月至2018年6月CPID患者分为观察组与对照组，各37例，对照组口服左氧氟沙星片和甲硝唑片治疗，在对照组的基础上，观察组给予加味当归芍药散水煎服。比较两组患者治疗前后的中医症状评分，MMP-2，ICAM-1，白细胞介素-1

(IL-1

)，IL-6，IL-4，IL-10，转化生长因子-

(TGF-

)，粒-巨核细胞集落刺激因子(GM-CSF)，肿瘤坏死因子-

(TNF-

)，全血黏度(

b)，血浆黏度(

p)，红细胞聚集指数(AI)，纤维蛋白原(Fib)水平。治并观察两组患者疗效、不良反应及复发情况。

结果：

观察组临床疗效优于对照组(

＝2.791，

0.05)。观察组治疗后的下腹疼痛、腰骶疼痛、带下量多、月经量多、腹部压痛、疲乏症状评分均明显低于对照组(

0.05)。观察组治疗后的MMP-2，ICAM-1，TNF-

，IL-1

，IL-6，GM-CSF，

b，

p，AI，Fib水平均低于对照组(

0.05)，观察组治疗后的IL-4，IL-10，TGF-

水平均高于对照组(

0.05)。随访3个月，观察组和对照组的复发率分别为2.70%，21.62%，观察组复发率低于对照组(

＝6.198，

0.05)。

结论：

加味当归芍药散治疗CPID的临床疗效显著，能有效缓解临床症状，大大降低复发率，这可能与改善调控MMP-2，ICAM-1水平，抑制炎症反应，改善血液流变学有关。

Abstract

Objective:

To explore the effect of modified Danggui Shaoyao San on matrix metalloproteinase-2(MMP-2)

intercellular adhesion molecule-1 (ICAM-1)

emorheology and inflammation in patients with chronic pelvic inflammatory disease.

Method:

Patients with chronic pelvic inflammatory disease during May 2017 to June 2018 were randomly divided into treatment group and control group

with 37 cases in each group. The control group was orally treated with levofloxacin tablets and metronidazole tablets. In addition to the therapy of the control group

the treatment group was also given modified Danggui Shaoyao San. Traditional Chinese medicine(TCM) symptom scores

MMP-2 and ICAM-1

interleukin-1

(IL-1

)

IL-6

IL-4

IL-10

and transforming growth factor-

(TGF-

)

grain-megakaryocyte colony stimulating factor (GM-CSF)

tumor necrosis factor-alpha (TNF-

)

whole blood viscosity (

plasma viscosity (

erythrocyte aggregation index (AI)

fibrinogen (Fib) before and after treatment were compared between two groups. The efficacy

adverse reactions and recurrence were observed in two groups.

Result:

The clinical efficacy of treatment group was better than that of the control group (

=2.791

0.05). The scores of lower abdominal pain

lumbosacral pain

subband pain

menstrual volume

abdominal tenderness and fatigue in treatment group were significantly lower than those in control group (

0.05). MMP-2

ICAM-1

TNF-

IL-1

IL-6

GM-CSF

Fib levels in the treatment group after treatment were significantly lower than those in control group (

0.05)

while IL-4

IL-10

TGF-

levels in treatment group after treatment were significantly higher than those in control group (

0.05). After 3 months of follow-up

the recurrence rates of observation group and control group were 2.70%and 21.62%

respectively

with statistically significant differences (

=6.198

0.05).

Conclusion:

Modified Danggui Shaoyao San has a significant clinical efficacy in the treatment of CPID

and can effectively relieve clinical symptoms and greatly reduce the recurrence rate

which may be related to the improvement of the regulation of MMP-2 and ICAM-1 levels

the inhibition of inflammatory reactions and the improvement of hemorheology.

关键词

慢性盆腔炎加味当归芍药散基质金属蛋白酶-2细胞间黏附分子-1血液流变学促炎因子抗炎因子

Keywords

chronic pelvic inflammationmodified Danggui Shaoyao Sanmatrix metalloproteinase-2intercellular cell adhesion molecule-1hemorheologypro-inflammatory factorsanti-inflammatory factor

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