Clinical Efficiency of Modified Yuyetang to Type 2 Diabetes Mellitus Combined with Coronary Heart Disease

Ling CHENG; Zhan-chuan LI; Jun-guo LIANG

doi:10.13422/j.cnki.syfjx.20191531

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Clinical Efficiency of Modified Yuyetang to Type 2 Diabetes Mellitus Combined with Coronary Heart Disease

Clinic | 更新时间：2021-02-09

- Clinical Efficiency of Modified Yuyetang to Type 2 Diabetes Mellitus Combined with Coronary Heart Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 21, Pages: 78-83(2019)
- 作者机构：
  
  内蒙古医科大学　第一附属医院，呼和浩特　 010050
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191531
  CLC： R25; R255.4; R256; R256.5
- Published：05 November 2019，
  
  Published Online：10 April 2019，
  
  Received：04 March 2019，
- 稿件说明：
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Ling CHENG, Zhan-chuan LI, Jun-guo LIANG. Clinical Efficiency of Modified Yuyetang to Type 2 Diabetes Mellitus Combined with Coronary Heart Disease. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(21):78-83(2019)
DOI：

Ling CHENG, Zhan-chuan LI, Jun-guo LIANG. Clinical Efficiency of Modified Yuyetang to Type 2 Diabetes Mellitus Combined with Coronary Heart Disease. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(21):78-83(2019) DOI： 10.13422/j.cnki.syfjx.20191531.

摘要

目的：

探讨玉液汤加味治疗2型糖尿病(T2DM)合并冠心病(气阴两虚兼痰或瘀证)的临床证状及抗炎和抗氧化作用机制。

方法：

将118例患者随机按数字表法分为对照组58例和观察组60例。对照组采用胰岛素或口服降糖药特制血糖；口服阿司匹林肠溶片，100 mg/次，1次/d；血脂异常，口服阿托伐他汀钙片，10 mg/次，1次/d；高血压，口服卡托普利片，12.5～25.0 mg/次，1次/d。观察组西医治疗措施同对照组，并给予玉液汤加味内服，1剂/d。两组疗程均为治疗3个月。检测治疗前后糖化血红蛋白(HbA1c)，空腹血糖(FPG)，餐后2 h血糖(2 hPG)，三酰甘油(TG)，总胆固醇(TC)，高密度脂蛋白胆固醇(HLD-C)，低密度脂蛋白(LDL-C)，载脂蛋白A(ApoA)，载脂蛋白B(ApoB)，降钙素原(PCT)，同型半胱氨酸(Hcy)，白细胞介素-6(IL-6)，肿瘤坏死因子-

(TNF-

)和超敏C反应蛋白(hs-CRP)，超氧化物歧化酶(SOD)，丙二醛(MDA)，谷胱甘肽过氧化物酶(GSH-Px)和8-异前列腺素F2a(8-ios-PGF2a)水平；进行治疗前后Gensini评分和中医证候评分；进行治疗前后心电图检测。

结果：

治疗后观察组HbA1c水平均低于对照组(

0.05)；观察组LDL-C和ApoB水平均低于对照组(

0.05)，HDL-C和ApoA水平均高于对照组(

0.05)；观察组Gensini评分和中医证候评分均低于对照组(

0.05，

0.01)；观察组患者PCT，Hcy，IL-6，TNF-

和hs-CRP均低于对照组(

0.01)；观察组患者MDA和8-ios-PGF2a均低于对照组(

0.01)，SOD和GSH-Px水平均高于对照组(

0.01)；经秩和检验分析；观察组心电图疗效优于对照组(

0.05)。

结论：

在降糖、调脂和抗血小板等治疗的基础上，给予玉液汤加味治疗T2DM合并冠心病患者，具有调节糖脂代谢作用，减轻冠状动脉狭窄程度，具有抗炎和抗氧化应激作用。

Abstract

Objective:

To discuss the clinical effect of modified Yuyetang to type 2 diabetes mellitus (T2DM) combined with coronary heart disease (deficiency of Qi and Yin or phlegm syndrome and stasis syndrome) and the mechanisms of anti-inflammation and anti-oxidation.

Method:

One hundred and eighteen patients were randomly divided into control group (58 cases) and observation group (60 cases) by random number table. Patients in control group was orally given insulin or special blood glucose for hypoglycemic agents

aspirin enteric-coated tablets

100 mg/time

1 time/day. Patients with dyslipidemia got atorvastatin

10 mg/time

1 time/day. And patients with hypertension got captopril tablets

12.5-25.0 mg/time

1 time/day. In addition to the therapy of control group

patients in observation group were also given modified Yuyetang

1 dose/day. A course of treatment was 3 months. Before and after treatment

levels of glycated hemoglobin (HbA1c)

fasting blood glucose (FPG)

2-hours postprandial glucose (2 hPG)

blood lipids triglyceride (TG)

total cholesterol (TC)

high density lipoprotein cholesterol (HLD-C)

low-density lipoprotein (LDL-C)

apolipoprotein A (ApoA)

apolipoprotein B (ApoB)

procalcitonin (PCT)

homocysteine (Hcy)

interleukin-6 (IL-6)

tumor necrosis factor-alpha (TNF-alpha) and hypersensitive C-reactive protein (hs-CRP)

superoxide dismutase (SOD)

malondialdehyde (MDA)

glutathione peroxidase (GSH-Px) and 8-Isoprostaglandin F2a (8-ios-PGF2a) were detected

Gensini and traditional Chinese medicine (TCM) syndrome were scored

and electrocardiogram was detected.

Result:

After treatment

levels of FPG

HbA1c

LDL-C

ApoB

scores of Gensini and TCM syndrome

PCT

Hcy

IL-6

TNF-

and hs-CRP in observation group were all lower than those in control group (

0.05

0.01)

and levels of MDA and 8-ios-PGF2a were lower than those in control group (

0.01)

while levels of HDL-C

ApoA

SOD and GSH-Px were higher than those in control group (

0.05

0.01). By rank sum test analysis

the effect of electrocardiogram was better than that in control group (

0.05).

Conclusion:

In addition to hypoglycemic

lipid-lowering and antiplatelet therapies

Modified Yuye decoction can regulate glucose and lipid metabolism of patients with T2DM and coronary heart disease

relieve degree of coronary artery stenosis

with anti-inflammatory and anti-oxidative stress effect.

关键词

2型糖尿病冠心病气阴两虚兼痰或瘀证玉液汤加味Gensini评分抗炎抗氧化

Keywords

Type 2 diabetes mellituscoronary heart diseasedeficiency of both qi and Yin and phlegm or blood stasis syndromemodified YuyetangGensini scoreanti-inflammatoryantioxidant

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