Effect of Autophagy in Treatment of Tumors with Traditional Chinese Medicine

Jing ZHU; Guang-bin SHANG; Jie ZHANG; Hui-juan SUN; Xiao-jun YAN

doi:10.13422/j.cnki.syfjx.20191321

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Effect of Autophagy in Treatment of Tumors with Traditional Chinese Medicine

Review | 更新时间：2021-02-09

- Effect of Autophagy in Treatment of Tumors with Traditional Chinese Medicine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 21, Pages: 220-226(2019)
- 作者机构：
  
  江西中医药大学　江西省中医病因生物学重点实验室，南昌　 330004
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191321
  CLC： R22; R242; R2-031; R285.5; R241.2
- Published：05 November 2019，
  
  Published Online：07 March 2019，
  
  Received：23 October 2018，
- 稿件说明：
扫描看全文
Jing ZHU, Guang-bin SHANG, Jie ZHANG, et al. Effect of Autophagy in Treatment of Tumors with Traditional Chinese Medicine. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(21):220-226(2019)
DOI：

Jing ZHU, Guang-bin SHANG, Jie ZHANG, et al. Effect of Autophagy in Treatment of Tumors with Traditional Chinese Medicine. [J]. Chinese Journal of Experimental Traditional Medical Formulae 25(21):220-226(2019) DOI： 10.13422/j.cnki.syfjx.20191321.

摘要

肿瘤的根治是世界难题，患者的生活质量和生存率不高。因此寻找一个药物靶点抑制肿瘤的发生发展变得就非常有意义。近年来医学研究的热点——自噬为自体的自我吞噬，是细胞清除受损或多余细胞器，并能适应外界环境压力来获得生存，影响肿瘤细胞生存、代谢、分化、衰老和死亡等多个生物行为过程，对细胞重塑及维持细胞生存动态平衡扮演了重要角色，特别是与肿瘤发生发展变化关系密切。自噬也是把双刃剑，对于单个肿瘤细胞和整个肿瘤的效应也可能不尽相同。当肿瘤细胞自噬出现异常时，或者细胞在低氧和营养缺乏条件下，不能及时清除自身细胞内受损的物质，此时自噬有利于肿瘤细胞增殖与存活。反之，适度的自噬作为肿瘤的抑制因子，具有抗肿瘤作用。中医药防治肿瘤历史悠久，具有低毒性和多目标的优点。通过整体和局部治疗效果，在癌症中具有综合治疗效果。随着肿瘤自噬的研究日益深入，不仅西药对肿瘤自噬的研究较多，而且单味中药和中药复方在国内外研究肿瘤自噬也与日俱增，其对自噬分子机制的最新见解导致了潜在药物靶点的发现。同时中医药研究肿瘤自噬取得了一定进展。笔者就中医对自噬的认识以及中医药调节肿瘤自噬的研究进展进行综述，希望为中医药在肿瘤自噬治疗研究中提供有益的借鉴。

Abstract

The cure of tumors is a difficulty in the world

and both the quality of life and the survival rate of patients remain low. Therefore

it is very meaningful to find a drug target to inhibit the occurrence and development of tumors. In recent years

autophagy or self-phagocytosis has become a hotspot of medical research. It can remove damaged or excess organelles from cells

be survived from external environmental pressures

and affect the survival

metabolism

differentiation

aging and death of tumor cells. The biological behavioral process plays important roles in remodeling and maintaining the dynamic balance of cell survival

especially in close relations to tumor development. Autophagy is also a double-edged sword in effect on a single tumor cell and the entire tumor. When the autophagy of the tumor cells is abnormal

or the cells are unable to remove the damaged substances in time under the conditions of hypoxia and nutrient deficiency

autophagy is beneficial to the proliferation and survival of the tumor cells. Contrarily

moderate autophagy acts as an inhibitor of tumors and has an anti-tumor effect. Traditional Chinese medicine (TCM) has a long history of controlling tumors

with the advantages of low toxicity and multiple targets. Through overall and local therapies

it has a comprehensive therapeutic effect in cancer. With the deepening of tumor autophagy research

in addition to western medicine researches on tumor autophagy

there are also domestic and foreign researches on the autophagy in single herb and TCM compounds. The latest insights into the molecular mechanism of autophagy have led to the discovery of potential drug targets. At the same time

TCM researches have made some progress in tumor autophagy. The authors review the research progress of autophagy in TCM and the research progress of effect of TCM in regulating tumor autophagy

in the hopes to provide useful reference for effect of TCM in the treatment of autophagy.

关键词

自噬中药单体中药复方肿瘤

Keywords

autophagytraditional Chinese medicine(TCM) monomerTCM compoundtumor

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