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铁皮石斛对小鼠慢性酒精性肝损伤模型血清ALT、AST、TC的影响
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浙江省重大科技攻关项目


Effect of Dendrobium on ALT, AST, TC in Serum of Chronic Alcoholic Liver Injury Mice
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A major scientific and technological projects, Zhejiang Province

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    摘要:

    【摘要】目的:观察不同剂量铁皮石斛及铁皮枫斗对小鼠慢性酒精性肝损伤模型血清ALT、AST、TC的影响。方法:雄性ICR小鼠,分为9组:三个鲜铁皮石斛组(3g/kg、6g/kg、9g/kg),三个铁皮枫斗组(0.45g/kg、0.90/kg、1.35g/kg),设立正常对照组、模型对照组、阳性对照(联苯双酯滴丸)组。采用连续灌胃给予56?白酒65天造成慢性酒精性肝损伤模型,每天给完药后2h灌予酒精造模。末次给予酒精12h后取血,测定血清ALT、AST、TC。结果:与正常对照组相比,模型对照组小鼠血清ALT、AST、TC明显升高。与模型对照组相比,鲜铁皮石斛(3g/kg)和铁皮枫斗(0.45g/kg)能降低血清ALT。鲜铁皮石斛(3g/kg、6g/kg)与铁皮枫斗(0.45g/kg)能降低血清AST、TC。铁皮枫斗(0.90g/kg、1.35g/kg)能降低血清AST。结论:铁皮石斛和铁皮枫斗均对慢性酒精性肝损伤小鼠的肝功能相关指标(ALT、AST、TC)有一定的改善作用。

    Abstract:

    Abstract:Objective To observe the effect of Dendrobium with different doses on ALT, AST, TC in the serum of chronic alcoholic liver injury mice. Methods Male ICR mice were divided into nine groups randomly: normal control group, model control group, positive control group, fresh Dendrobium groups with three doses(3g/kg,6g/kg,9g/kg), dried Dendrobium groups with three doses(0.45g/kg,0.90g/kg,1.35g/kg), gastric infusion for 65 days. The mice mode1 of chronic alcoholic 1iver injury was established by filling the stomach with alcohol after the administration for 65 days, once a day. The blood was taken to separate into serum and the activity of ALT, AST and the content of TC in the serum were determined. Results Compared with the normal control group, the ALT, AST, TC in the serum of model control group increased. Compared with model control group, fresh Dendrobium (3g/kg) and dried Dendrobium (0.45g/kg) could decrease ALT in the serum;fresh Dendrobium (3g/kg, 6g/kg) and dried Dendrobium (0.45g/kg) could decrease AST, TC in the serum; dried Dendrobium (0.90g/kg, 1.35g/kg) could decrease AST in the serum. Conclusion Fresh and dried Dendrobium could improve effectively the activity of ALT, AST and decrease the content of TC in the serum of chronic alcoholic 1iver injury mice.

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吕圭源,陈素红.铁皮石斛对小鼠慢性酒精性肝损伤模型血清ALT、AST、TC的影响[J].中国实验方剂学杂志,,():

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  • 收稿日期:2010-01-18
  • 最后修改日期:2010-02-24
  • 录用日期:2010-02-27
  • 在线发布日期: 2010-06-28
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