欢迎访问《中国实验方剂学杂志》编辑部网站!
Box-Behnken响应面法优选川芎超微粉碎工艺
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

国家重大新药创制项目


Optimization of Ultrafine Grinding Technology for Chuanxiong Rhizoma by Box-Behnken Design
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:优选川芎的超微粉碎工艺。方法:选择投料量、含水量、粉碎时间为自变量,平均粒径为因变量,通过Box-Behnken响应面法优选川芎的超微粉碎工艺,并考察超微粉碎前后的粉体学性质和吸湿性。结果:最佳超微粉碎工艺为投料量1.3 kg,含水量4%,粉碎时间19 min;平均粒径19.187 μm,与模型预测值18.357 7 μm的偏差仅4.5%。川芎普通粉末和超微粉的休止角分别为(49.4±0.03),(50.2±0.02)°,松密度分别为(0.429±0.003),(0.363±0.005) g·mL-1,振实密度分别为(0.609±0.05),(0.556±0.10) g·mL-1,吸湿平衡时间均约80 h。结论:优选的超微粉碎工艺合理可行,川芎超微粉的制剂过程中需加入助流剂等辅料以改善粉体的流动性,川芎超微粉碎过程中宜严格控制湿度。

    Abstract:

    Objective: To optimize ultrafine grinding process of Chuanxiong Rhizoma. Method: Taking feeding amount, moisture content and grinding time as independent variables, average particle size as dependent variable, Box-Behnken response surface methodology was adopted to optimizeultrafine grinding process of Chuanxiong Rhizoma, its powder properties and hygroscopicity before and after smashed were investigated. Result: Optimum ultrafine grinding process was as follows:feeding amount1.3 kg, moisture content 4%, grinding time 19 min;Deviation between the predicted value(18.357 7 μm) and the measured value(19.187 μm) of average particle size was only 4.5%.Response angles of ordinary and ultrafine powder were (49.4±0.03) and (50.2±0.02) °, bulk densities were (0.429±0.003) and (0.363±0.005) g·mL-1, tap densities were (0.609±0.05) amd (0.556±0.10) g·mL-1, moisture equilibrium times were about 80 h. Conclusion: Optimized ultrafine grinding process was reasonable and feasible, preparation technology of ultrafine powder of Chuanxiong Rhizoma should add flow aid and other auxiliary materials in order to improve fluidity of powder, ultrafine grinding process should strictly control humidity.

    参考文献
    相似文献
    引证文献
引用本文

向孙敏,杨安东,朱宁,逯多,郝月莆,秦春凤. Box-Behnken响应面法优选川芎超微粉碎工艺[J].中国实验方剂学杂志,2014,20(8):15~18

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2013-11-25
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2014-04-16
  • 出版日期:

地址:北京东直门内南小街16号

邮编:100700

电话:010-84076882

E-mail:syfjx_2010@188.com

中国实验方剂学杂志 ® 2021 版权所有

技术支持:北京勤云科技发展有限公司