Abstract：Objective To observe the effect of Dendrobium with different doses on ALT, AST, TC in the serum of chronic alcoholic liver injury mice. Methods Male ICR mice were divided into nine groups randomly: normal control group, model control group, positive control group, fresh Dendrobium groups with three doses(3g/kg,6g/kg,9g/kg), dried Dendrobium groups with three doses(0.45g/kg,0.90g/kg,1.35g/kg), gastric infusion for 65 days. The mice mode1 of chronic alcoholic 1iver injury was established by filling the stomach with alcohol after the administration for 65 days, once a day. The blood was taken to separate into serum and the activity of ALT, AST and the content of TC in the serum were determined. Results Compared with the normal control group, the ALT, AST, TC in the serum of model control group increased. Compared with model control group, fresh Dendrobium (3g/kg) and dried Dendrobium (0.45g/kg) could decrease ALT in the serum；fresh Dendrobium (3g/kg, 6g/kg) and dried Dendrobium (0.45g/kg) could decrease AST, TC in the serum; dried Dendrobium (0.90g/kg, 1.35g/kg) could decrease AST in the serum. Conclusion Fresh and dried Dendrobium could improve effectively the activity of ALT, AST and decrease the content of TC in the serum of chronic alcoholic 1iver injury mice.
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