We selected Aconitum carmichaelii Debx. and Fritillaria thunbergii MiO.

a couple of counteracted drugs

as study objects to verify the mechanism of counteracted drugs by the anti-tumor experiments

which include studies of Anti-tumor effect on Lewis carcinoma of Mouse by application of Aconitum carmichaelii Debx. and Fritillaria thunbergii MiQ.singly or matched and Affection on appoptosis of LM-2 carcinoma cells.Both the drugs used singly can inhibit tumor growth and tumor metastasis

but two drugs matched can’t reinforce this effect;there were statistic differences with two drugs used singly on affection of thymus gland

but the matched drugs were not effective.Aconite decoction can reinforce the apoptosis of LM-2 cells dosage dependently within 5mg/mL～75mg/mL

moreover

the longer the cell were stimulated

the higher the apoptosis rate;while LM-2 cells stimulated by fritillaryia decoction with 75mg/mL for 48h

the rate of apoptosis rose;compare with aconite decoction used singly

aconite matched with fritillaria（1∶1） under same concentration as used singly can depress cells apoptosis significantly

which show that the matched drugs can suppress LM-2 cells apoptosis.As showed by the results

the statement of “aconite counteracts fritillaria” was supported by our experiment.