References
- 1.LI Y M, TIAN X T, LUO J Y, et al. Molecular mechanisms of aging and anti-aging strategies[J].Cell Commun Signal, 2024, 22(1): 285.
- 2.QIAO X. Ageing in China: Past, present, and future[J]. Social Policy Res, 2024,doi:.
- 3.SOENEN S, RAYNER C K, JONES K L, et al. The ageing gastrointestinal tract [J].Curr Opin Clin Nutr Metab Care, 2016, 19(1):12-18.
- 4.ZHENG L, DUAN S L. Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis[J].World J Gastroenterol, 2023, 29(16): 2380-2396.
- 5.ZHANG X, ZHU F, WEN J, et al. Mechanism of reversal of precancerous lesions of gastric cancer by celastrus orbiculatus extract via regulating Lgr5/Wnt/β-catenin signaling pathway[J].Chin J Exp Tradit Med Form, 2024,30(12):70-77.
- 6.KOCH S. Extrinsic control of Wnt signaling in the intestine [J]. Differentiation, 2017, 97: 1-8.
- 7.ZHOU J Y, ZAN G X, ZHU Q J, et al. Recombinant porcine R-spondin 1 facilitates intestinal stem cell expansion along the crypt-villus axis through potentiating Wnt/β-catenin signaling in homeostasis and deoxynivalenol injury[J]. J Agric Food Chem, 2022, 70(34): 10644-10653.
- 8.WANG Y, ZHANG Z, LIU Z. Theoretical exploration of the relationship between the liver and aging[J]. J Shandong Univ Tradit Chin Med,2007,31(4):315-318.
- 9.LI W,WANG S,WANG H,et al. Effects of Bugan powder on learning and memory ability and oxidative damage in aged rats[J].J Tradit Chin Med Pharm, 2020,35(12):6033-6037.
- 10.WANG S,LI W,WANG H,et al. Effects of Bugansan on learning and memory function of aging rats based on BDNF/TrkB mediated hippocampal synaptic plasticity[J]. J Beijing Univ Tradit Chin Med,2021,44(4):323-331.
- 11.ZHANG C,JIA X,HUANG W,et al. Shouwuwan regulates synaptic plasticity of hippocampal neurons in rat model of D-galactose-induced aging via mTOR signaling pathway[J].Chin J Exp Tradit Med Form, 2023,29(17):116-125.
- 12.LI W.Discussion on the relationship between liver-Qi deficiency and aging and the intervention mechanism of Bugan san from the perspective of learning and memory impairment caused by inflammatory injury[D].Shijiazhuang:Hebei Medical University of Chinese Medicine,2021.
- 13.PENG D,GUO Y,LI Y,et al. The effect of Shenqi pills on small intestinal stem cells and microenvironment Wnt/β-catenin signaling pathway in aging rats[J].J Chin Med Mater, 2017,40(9):2177-2181.
- 14.HAJAM Y A, RANI R, GANIE S Y, et al. Oxidative stress in human pathology and aging:Molecular mechanisms and perspectives[J].Cells, 2022, 11(3): 552.
- 15.SONG R,HU M,QIN X, et al. The roles of lipid metabolism in the pathogenesis of chronic diseases in the elderly[J]. Nutrients, 2023, 15(15): 3433.
- 16.NANKI K, TOSHIMITSU K, TAKANO A, et al. Divergent routes toward Wnt and R-spondin niche independency during human gastric carcinogenesis[J].Cell,2018,174(4): 856-869.
- 17.SHARMA V, CHANDER SHARMA P, REANG J, et al. Impact of GSK-3β and CK-1δ on Wnt signaling pathway in alzheimer disease:A dual target approach[J].Bioorg Chem, 2024, 147: 107378.
- 18.LIU H, LIANG M, DENG Y, et al. Simulated microgravity alters p-glycoprotein efflux function and expression via the Wnt/β-catenin signaling pathway in rat intestine and brain[J].Int J Mol Sci,2023,24(6):5438.
- 19.GEHART H,CLEVERS H.Tales from the crypt:New insights into intestinal stem cells[J].Nat Rev Gastroenterol Hepatol,2019,16(1):19-34.
- 20.GREGORIEFF A,LIU Y,INANLOU M R,et al.Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer[J].Nature,2015,526(7575):715-718.
- 21.FAN H, WU J,YANG K,et al.Dietary regulation of intestinal stem cells in health and disease[J].Int J Food Sci Nutr,2023,74(7):730-745.
- 22.YAN K S, JANDA C Y, CHANG J, et al. Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal[J].Nature,2017,545(7653):238-242.
- 23.LI W,WANG S,WANG J,et al. Mechanism of Bugansan Decoction in ameliorating learning and memory impairment in D-galactose-induced aging rats based on AGEs/RAGE/NF-κB pathway[J].Digital Chin Med,2023,6(3):317-327.
- 24.ZHANG Y,BAI D,HUO R,et al. Effects of Bugan powder on liver injury in aging rats based on mitophagy[J]. China J Tradit Chin Med Pharm,2023,38(3):1039-1045.
- 25.BAI D,ZHANG Y,HUO R,et al. Effects of Bugan powder on myocardial injury of aging rats based on cardiomyocyte apoptosis mediated by Rho/ROCK pathway[J].Tradit Chin Drug Res Clin Pharmacol,2022,33(8):1032-1039.


