تطور استخدام الأدوية الصينية في رقابة مسار إشارة بروتين (β-catenin) Wnt/ لمكافحة سرطان البروستاتا

  • role: First author第一作者
  • Affiliation:

    The First Clinical Medical College of Heilongjiang University of Chinese Medicine,Harbin 150000,China

  • Email:842718601@qq.com
  • Introduction:西E-mail842718601@qq.com
LING Lu1,  
  • Affiliation:

    The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150000,China

XU Jingyu2,  
  • Affiliation:

    The First Clinical Medical College of Heilongjiang University of Chinese Medicine,Harbin 150000,China

ZHAO Junfei1,  
  • role: Corresponding author通信作者
  • Affiliation:

    The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150000,China

  • Email:zyylsj@126.com
  • Introduction:西E-mailzyylsj@126.com
LIU Songjiang2*

ملخص

سرطان البروستاتا هو ورم خبيث شائع في الخلايا الظهارية للبروستاتا في الذكور. مع تزايد تواتر الشيخوخة في سكان الصين، فإن معدلات الإصابة بهذا المرض تستمر في الارتفاع. رغم أن أسباب سرطان البروستاتا الدقيقة لم تعرف بالكامل، فقد تم تأكيد علاقته الوثيقة بعوامل متعددة مثل الحساسية الجينية للفرد، والطفرات الجينية، وعادات التغذية ونمط الحياة وغيرها. أظهرت الدراسات أن تفعيل مسار إشارة بروتين (β-catenin) Wnt/ بشكل غير طبيعي يلعب أيضا دورا هاما في نشوء وتطور سرطان البروستاتا. كشفت العديد من الدراسات التجريبية أن الأدوية الصينية، من خلال آلياتها المتعددة وتأثيراتها على العديد من النقاط المهمة في العمليات الحيوية الرئيسية مثل الانتشار والتحرك والاختراق ونمو الأوعية الدموية والتحول الظهاري-الخلوي، تمتلك تأثيرات تنظيمية ملحوظة على خلايا سرطان البروستاتا، مما يظهر إمكانيات ممتازة في منع تطور سرطان البروستاتا وتحسين توقعات المرضى. وقد أصبحت في السنوات الأخيرة محورا للبحث في علاج سرطان البروستاتا. استنادا إلى ذلك، حاول هذا البحث تجميع وتقييم الدراسات الداخلية والخارجية حول استخدام الأدوية الصينية لتنظيم مسار إشارة بروتين (β-catenin) Wnt/ لعلاج سرطان البروستاتا، يحلل التدخل الدوائي للأدوية الصينية في هذا المسار ويستنتج 29 مكونا نشطا للأدوية الصينية من أنواع مختلفة مثل القلويات النباتية (البابريٌين، البيريبيرين إلى آخر)، الفلافونويدات (إيروميتين، ايبيغينين إلى آخر)، الفينول (السوسنج، السيليكرون إلى آخر)، الترويان (ستيكوبرينا، الآيسوليستيونين إلى آخر)، الخيار (الريموسوريدان) والصابونين (تشي هو صابونين D)، دواء واحد (الزئبق)، مجموعة دماغية واحدة (تانغوي، ستيلفيا) ومرتين من مستحضرات الأدوية الصينية (ظيفية في تمرين إعلان الكريدينسی الذهني إلى آخر). ويتسع هذا البحث لفهم عميق لآليات مرض البروستاتا واستكشاف نقاط العلاج المحتملة، لتحقيق ولإعلام الأبحاث السريرية وتطوير الأدوية الجديدة من مناظر وأفكار جديدة، وبالتالي دفع تقديم الإنجازات والابتكارات المتقدمة في استراتيجيات علاج سرطان البروستاتا.

مفهوم

سرطان البروستاتا؛ Wnt/ بروتين (β-catenin) المسار المتتالي؛ أدوية صينية؛ تطور البحث؛ آلية العمل

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