تناول الشراب الخمسة لعلاج ربو البلل القريب الجاف للجلد

  • role: First author第一作者
  • Affiliation:

    Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine,School of Pharmacy, Hubei University of Chinese Medicine,Wuhan 430065,China

  • Email:1968359096@qq.com
  • Introduction:韩康宁,在读硕士,从事中药药效物质基础研究,E-mail:1968359096@qq.com
HAN Kangning1,  
  • Affiliation:

    Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine,School of Pharmacy, Hubei University of Chinese Medicine,Wuhan 430065,China

HU Junjie1,  
  • Affiliation:

    Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine,School of Pharmacy, Hubei University of Chinese Medicine,Wuhan 430065,China

LI Juan1,  
  • Affiliation:

    Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine,School of Pharmacy, Hubei University of Chinese Medicine,Wuhan 430065,China

ZHANG Min1,  
  • Affiliation:

    Clinical College of Chinese Medicine,Hubei University of Chinese Medicine,Wuhan 430060,China

ZHOU Xian2,  
  • role: Corresponding author通信作者
  • Affiliation:

    Clinical College of Chinese Medicine,Hubei University of Chinese Medicine,Wuhan 430060,China

  • Email:newforest@163.com
  • Introduction:刘松林,博士,教授,从事经方防治消化及心血管疾病的临床基础研究,E-mail:newforest@163.com; *
LIU Songlin2*,  
  • role: Corresponding author通信作者
  • Affiliation:

    Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine,School of Pharmacy, Hubei University of Chinese Medicine,Wuhan 430065,China

  • Email:chenxin30172@hotmail.com
  • Introduction:陈新,博士,副研究员,从事中药药效物质基础研究,E-mail:chenxin30172@hotmail.com
CHEN Xin1*

ملخص

الهدف من استخدام الكروماتوغرافية السائلة عالية الكفاءة - الكتلة الشبكية الرباعية - الطيران زمني متكامل (UPLC-Q-TOF-MS/MS) بالإضافة إلى الفارماكولوجيا الشبكية والتوقعات الجزيئية لاستكشاف تأثير الدواء لمستحضر إيريا سغو تن آربين إيرثيكسيكايش نيغليخبكيغ شيتشقبيغ آوفيكايجت إر أومكم باجحيجبت إيت أوكشوميك. وفد؟تستخدم تجربة على الحيوانات للتحقق من وظيفة الدواء ضد الرعاف الرطب بشكل حجبي؛ تتضمن الـUPLC - Q - TOF - MS / MS تحليل الحقن الدموي بمكن ننلة؛ يتعامل الإنترنت الفارماكولوجي مع المكونات الرئيسية والنقاط الأساسية ومسارات الإشارة من خلال المضماريين؛ يعمل مضماريان إيل دوك2 على الإنترنت ناكست مخدوع عملية الانضمام الجزيئي. يقفز من علامات الجلدولوج أكبر-الدواء بالإحساس مع التلوين المرضي مما يوضح من خلاله أشجار الرئة الرمادية لعلاج الرعاف الرطب. يتكون لعلاج الرعاف الرطب غشديتذث؛ تحت فحص كانك الحوس؛ تستخدم الجهاز الجنيني API؛ تعمل مواد GCS و CIC و PEC بقياس اجلذأف الطبيعة المريضةى؛ تشير التحليلات الصلبة إلى زيادة مستوى قواسم المعدة والأزعاج وIL-4 وIL-13 في أجدا الجلدوغ؛ تشير البيولوجيات الصلبحة إلى أزايتال شعف المعدة واجللادة فائاقة كمعل سبيظ. الأخذ من نتائج معطيات الحيوانات يظهر من خلاله أن دواء الجلدولوج الرطب يصبح أكثر انقساماً، والجلدوغ يصبح قششأ. الطلع هو نصمسىت؟؟يعطىونMMكXY يربتMMY. ححثيم؟MMكXY. وفد؟MMكXY ححثيمMMY. وفد؟ححثيمMM. وفد؟MMكXY

مفهوم

هضيبضيت؛ربو الجلد؛الكروماتوغرافية السائلة عالية الكفاءة - الكتلة الشبكية الرباعية - الطيران الزمني المتكامل (UPLC-Q-TOF-MS/MS)؛الفارماكولوجيا الشبكية؛الجنينوس غرأج دخذ; الجربىز

References

  1. 1.
    YAN F,LI F,LIU J,et al.The formulae and biologically active ingredients of Chinese herbal medicines for the treatment of atopic dermatitis[J].Biomed Pharmacother,2020,127:110142.
  2. 2.
    SIDBURY R,DAVIS D M,COHEN D E,et al.Guidelines of care for the management of atopic dermatitis: Section 3.Management and treatment with phototherapy and systemic agents[J].J Am Acad Dermatol,2014,71(2):327-349.
  3. 3.
    ZHANG L,ZHANG D M,LUO Y X,et al.Analysis on the current application status of traditional Chinese medicine external treatment for eczema[J].J Jiangxi Uuiv Chin Med,2023,35(6):128-132.
  4. 4.
    SROKA-TOMASZEWSKA J,TRZECIAK M.Molecular mechanisms of atopic dermatitis pathogenesis[J].Int J Mol Sci,2021,22 (8):4130.
  5. 5.
    LIN Y,CHEN X J,HE L,et al.Systematic elucidation of the bioactive alkaloids and potential mechanism from Sophora flavescens for the treatment of eczema via network pharmacology[J].J Ethnopharmacol,2023,301:115799.
  6. 6.
    MA H,ZHAI X X,YAN Y H,et al.A review of studies on Chinese medicine in the diagnosis and treatment of eczema[J].Chin J Basic Med Tradit Chin Med,2023,29(9):1574-1578.
  7. 7.
    DIAO Q C,LIU Y.Expert consensus on Chinese medicine diagnosis and treatment of eczema (eczema)[J].Chin J Dermato Venerol Integ Trad W Med,2021,20(5):517-521.
  8. 8.
    ZHENG W J.Based on date mining to explore the experience of traditional Chinese medicine master MEI Guoqiang in treating renal diseases[D].Wuhan:Hubei University of Chinese Medicine,2021.
  9. 9.
    HU Y X,CHEN Z Z,LIU C S,et al.Effect of Runzao Zhiyang capsule on gut microbiota and short-chain fatty acids in eczema rats[J].China Pharmacy,2024,35(19):2372-2377.
  10. 10.
    YANG S R.To investigate the mechanism of eczema cream on atopic dermatitis rat model based on TLR4/MyD88/NF-κB signaling pathway[D].Lanzhou:Gansu University of Chinese Medicine,2024.
  11. 11.
    LI Y M,MA C C,NIU F Q,et al.Exploring the mechanism of Fuyan Jing gel in treating chronic eczema based on the JAK1/STAT5 signaling pathway[J].Chin J Clin Pharmacol Ther,2024,29(9):1011-1018.
  12. 12.
    XIE Z Q,YUAN J Q,LI J L,et al.Therapeutic effect and immune mechanism of Artemisia annua L.ointment on mouse eczema models[J].Chin J Pharmacovigil,2024,21(6):617-624.
  13. 13.
    MA X,HAO M,ZHANG M H,et al.Protective effect and mechanism of turkish gall ointment on 2,4-dinitrochlorobenzene-induced eczema in rats[J].World Chin Med,2023,18(18):2597-2602.
  14. 14.
    LI H F,LIN X D.Research ideas for modeling damp-heat evidence in warm diseases[J].Hubei J Tradit Chin Med,2012,34(7):33-34.
  15. 15.
    Spleen and Stomach Diseases Branch, China Association of Chinese Medicine.Experts consensus on traditional Chinese medicine diagnosis and treatment of syndrome of dampness-heat of spleen and stomach (2023)[J].China J Tradit Chin Med Pharm,2024,39(8):4221-4225.
  16. 16.
    LI X Y,LIANG L N,LI J H,et al.Establishment and evaluation of a rat model integrating spleen deficiency syndrome and wet age-related macular degeneration pathology[J].J Tradit Chin Ophthalmol,2024,34(1):1-8.
  17. 17.
    MIAO M S,TIAN S,BAI M.Specifications for preparation of eczema models (Draft)[J].Chin J Exp Tradit Med Form,2017,23(24):6-10.
  18. 18.
    YU Z J,LIU Y J,WANG P,et al.Research progress on antitumor effects of Lysimachia capillipes Hemsl[J].Chin Pharmacol Bull,2018,34(11):1492-1495.
  19. 19.
    ZHENG T,FAN M,WEI Y,et al.Huangbai liniment ameliorates skin inflammation in atopic dermatitis[J].Front Pharmacol,2021,12:726035.
  20. 20.
    PAN J,ZHANG Q H,FAN H W,et al.Exploration of potential active ingredients and mechanism of action of Xihuang pill-medicated serum against glioma based on HPLC-Q-TOF-MS/MS, network pharmacology and experimental verification[J].Acta Pharm Sin,2024,59(3):693-703.
  21. 21.
    ZHONG X,ZHANG Y,LI J,et al.Mechanism of Astragali Radix-Aconiti Lateralis Radix Praeparata in treatment of heart failure based on UPLC-Q-TOF-MS and network pharmacology[J].Chin J Exp Tradit Med Form,2023,29(3):70-80.
  22. 22.
    SHI M,REN B N,QIU Z H,et al.Rapid identification of the components in Phellodendri chinensis Cortex based on UPLC-Q-TOF-MS[J].Chin J Hosp Pharm,2022,42(21):2225-2229.
  23. 23.
    LONG L,FENG H X,WANG C M,et al.Qualitative evaluation of Smilax china L.by UFLC-Q-TOF-MS/MS combined with fingerprint[J].Info Tradit Chin Med,2021,38(2):16-23.
  24. 24.
    YAN L T,SONG Y G,AI Z F,et al.Comparation of differences in chemical components of different varieties of Achyranthes bidentata based on UPLC-Q-TOF-MS/MS technology combined with multivariate statistical analysis[J].Chin Tradit Herb Drugs,2024,55(7):2160-2174.
  25. 25.
    CAO Y,DAI G L,WANG Y Q,et al.Analysis and evaluation on atractylodes-cyperus alcohol extract by UPLC-Q-TOF-MS/MS and HPLC[J].Chin Pharm J,2023,58(19):1736-1743.
  26. 26.
    CUTOLO M,CAMPITIELLO R,GOTELLI E,et al.The role of M1/M2 macrophage polarization in rheumatoid arthritis synovitis[J].Front Immunol,2022,13:867260.
  27. 27.
    PEMMARI A,PAUKKERI E L,HÄMÄLÄINEN M,et al.MKP-1 promotes anti-inflammatory M(IL-4/IL-13) macrophage phenotype and mediates the anti-inflammatory effects of glucocorticoids[J].Basic Clin Pharmacol Toxicol,2019,124(4):404-415.
  28. 28.
    YI W Q,HAO W G,LIU R,et al.Early diagnosis of serum pepsinogen Ⅰ、Ⅱ and gastrin 17 in patients with chronic atrophic gastritis[J].Med J West Chin,2022,34(7):1021-1025.
  29. 29.
    MA D,ZHOU B.Clinical experience of ZHOU Bin in treating chronic atrophic gastritis with the theory of gallbladder Qi lifting[J].Chin J Tradit Chin Med Pharm,2020,35(10):4989-4992.
  30. 30.
    HE Q,QI S M,WANG J Z.Research progress of gastrins-targeted antineoplastic drugs[J].J Pharm Anal,2018,38(1):56-66.
  31. 31.
    ZENG J M,FAN C L,DENG J,et al.Inhibition of emodin on STAT3,VEGFA,and p-ERK protein expressions in mouse model of dorsal root ganglion compression and its analgesic effect[J].J Hunan Univ Chin Med,2024,44(9):1583-1591.
  32. 32.
    HU L,WANG J,WU N,et al.Utilizing network pharmacology and experimental validation to investigate the underlying mechanism of phellodendrine on inflammation[J].PeerJ,2022,10:e13852.
  33. 33.
    SUN M H.Angelica ferulic acid on the Inhibition of hepatic stellate cell proliferation and the effects on the expression of JAK2 and STAT3[D].Lanzhou:Gansu University of Chinese Medicine,2022
  34. 34.
    LV Y,HAO Y K,ZHANG Z L.Quercetin inhibits H2O2-induced apoptosis and injury of human hepatocytes L-02 via the Nrf2/HO-1 pathway[J].Cent South Pharm,2021,19(1):44-50.
  35. 35.
    FENG Y Z.Studies on preparation,quality standard and potential pharmacodynamic of Sanren granules[D].Changchun:Changchun University of Chinese Medicine,2023.
  36. 36.
    HU S Y,LI L E,CHAI X Y,et al.Clinical observation on effect of indigo naturalis ointment in treating psoriasis in the active stage of blood-heat syndrome[J].World Chin Med,2023,18(8):1131-1135.
  37. 37.
    LIU J S, YUE J R, LI Y T, et al. Immunological mechanism of Ermiao powder improving inflammation in rats with collagen-induced arthritis through α7nAChR-JAK2/STAT3 pathway[J].China J Chin Mater Med, 2024,49(13):3591-3599.
  38. 38.
    XUE C,YAO Q,GU X,et al.Evolving cognition of the JAK-STAT signaling pathway:Autoimmune disorders and cancer[J].Signal Transduct Target Ther,2023,8(1):204.
  39. 39.
    YASUDA T,FUKADA T,NISHIDA K,et al.Hyperactivation of JAK1 tyrosine kinase induces stepwise,progressive pruritic dermatitis[J].J Clin Invest,2016,126(6):2064-2076.
  40. 40.
    MA X N,ZHANG J C,YU T,et al.Mechanism of Dihuangyin in treatment of mice with atopic dermatitis by regulating JAK1/STAT3 signaling pathway[J].Chin J Exp Tradit Med Form,2024,30(10):11-19.
  41. 41.
    HU L,LIU R,ZHANG L.Advance in bone destruction participated by JAK/STAT in rheumatoid arthritis and therapeutic effect of JAK/STAT inhibitors[J].Int Immunopharmacol,2022,111:109095.
  42. 42.
    SCHMIDT-ARRAS D,GALUN E,ROSE-JOHN S.The two facets of gp130 signalling in liver tumorigenesis[J].Semin Immunopathol,2021,43(4):609-624.

قراءة النص الكامل

The above content is generated by Large Model Translation. The translated content is for reference only. We do not assume any commercial or legal responsibilty for any consequences arising from the use of our website