References

1. 1.
   SCHMIDT-RIOVALLE J， ABU EJHEISHEH M ， MEMBRIVE-JIMÉNEZ M J， et al. Quality of life after coronary artery bypass surgery： A systematic review and Meta-analysis ［J］. Int J Environ Res Public Health， 2020， 17（22）： 8439.
2. 2.
   LIU S， LI Y， ZENG X， et al. Burden of cardiovascular diseases in China， 1990-2016： Findings from the 2016 global burden of disease study ［J］. JAMA Cardiol， 2019， 4（4）： 342-352.
3. 3.
   The Writing Committee of the Report on Cardiovascular Health Diseases in China. Interpretation of report on cardiovascular health and diseases in China 2022 ［J］. Chin J Cardiovasc Med， 2023， 28（4）： 297-312.
4. 4.
   LI Y， CHEN B， YANG X， et al. S100a8/a9 signaling causes mitochondrial dysfunction and cardiomyocyte death in response to ischemic/reperfusion injury ［J］. Circulation， 2019， 140（9）： 751-764.
5. 5.
   REN J Y， HE G X， QIN W B， et al. Advances in medication and prevention of myocardial ischemia reperfusion injury after percutaneous coronary intervention ［J］. Guangxi Med J， 2018， 40（18）： 2187-2190，2197.
6. 6.
   YU Y， SHEN M， SONG Q， et al. Biological activities and pharmaceutical applications of polysaccharide from natural resources： A review ［J］. Carbohydr Polym， 2018， 183： 91-101.
7. 7.
   FARíAS J G， MOLINA V M， CARRASCO R A， et al. Antioxidant therapeutic strategies for cardiovascular conditions associated with oxidative stress ［J］. Nutrients， 2017， 9（9）： 966.
8. 8.
   PENA E， BRITO J， EL ALAM S ， et al. Oxidative stress， kinase activity and inflammatory implications in right ventricular hypertrophy and heart failure under hypobaric hypoxia ［J］. Int J Mol Sci， 2020， 21（17）： 6421.
9. 9.
   SONG J S， CAO C， LI H R， et al. Mechanisms of oxidative stress in myocardial ischemia-reperfusion injury and protective effects of traditional Chinese medicines ［J］. China J Chin Mater Med， 2024， 49（13）： 3452-3461.
10. 10.
    SEMENZA G L. Regulation of oxygen homeostasis by hypoxia-inducible factor 1 ［J］. Physiology （Bethesda）， 2009， 24： 97-106.
11. 11.
    XU B， JIAO J， NIE B. Effect of Bawei Chenxiang powder on SOD，MDA and apoptosis of myocardial cells in ischemia-reperfusion injury ［J］. Jilin J Chin Med， 2021， 41（3）： 376-380.
12. 12.
    XIE J， WANG Y Y， LI J X， et al. Effect and mechanism of Poria cocos polysaccharides on myocardial cell apoptosis in rats with myocardial ischemia-reperfusion injury by regulating Rho-ROCK signaling pathway ［J］. China J Chin Mater Med， 2023， 48（23）： 6434-6441.
13. 13.
    ZHAO W J， LI C， LI Z J， et al. Effect of Chuanxiong polysaccharide on myocardial ischemia-reperfusion injury in rats ［J］. Shaanxi J Tradit Chin Med， 2023， 44（12）： 1704-1708.
14. 14.
    LIU J J， ZHAO G X， HE L L， et al. Lycium barbarum polysaccharides inhibit ischemia/reperfusion-induced myocardial injury via the Nrf2 antioxidant pathway ［J］. Toxicol Rep， 2021， 8： 657-667.
15. 15.
    WANG M， KAUFMAN R J. Protein misfolding in the endoplasmic reticulum as a conduit to human disease ［J］. Nature， 2016， 529（7586）： 326-335.
16. 16.
    WANG K Y， LI X L， CAI Y Q. Research progress of endoplasmic reticulum stress in heart diseases ［J］. Chin J Clin Pharmacol Ther， 2019， 24（11）： 1310-1314.
17. 17.
    TANG Q， LIU Q， LI Y， et al. CRELD2， endoplasmic reticulum stress， and human diseases ［J］. Front Endocrinol （Lausanne）， 2023， doi： .
18. 18.
    WANG X， XU L， GILLETTE T G， et al. The unfolded protein response in ischemic heart disease ［J］. J Mol Cell Cardiol， 2018， 117： 19-25.
19. 19.
    REN J， BI Y， SOWERS J R， et al. Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases ［J］. Nat Rev Cardiol， 2021， 18（7）： 499-521.
20. 20.
    SHEN Y J. Effect and mechanism of astragalus polysaccharide on hypoxia/reoxygenation injury of neonatal rat cardiomyocytes ［J］. Cardio-cardiovasc Dis Prev Treat， 2021， 21（5）： 441-444，479.
21. 21.
    WANG J Y， LI J， YU F， et al. Effects of Bletilla striata polysaccharide on PI3K/Akt/GRP78 signaling pathway and endoplasmic reticulum stress apoptosis in myocardial infarction rats ［J］. Chin J Gerontol， 2022， 42（1）： 108-112.
22. 22.
    CUI Y Y， YANG L X， MI D H， et al. Effects of Angelica sinensis polysaccharide on the apoptosis of cardiomyocytes in diabetic KK-Ay mice ［J］. China Pharm， 2023， 34（10）： 1211-1215.
23. 23.
    CHEN W， WANG Y， PAN Z， et al. Protective effects of dexmedetomidine on the ischemic myocardium in patients undergoing rheumatic heart valve replacement surgery ［J］. Exp Ther Med， 2021， 21（5）： 427.
24. 24.
    LI P， WANG J， DAI C X， et al. Effect of the infusion with mesenchymal stem cells before transplantation on the renal inflammatory cell infiltration and the expression of TNF-α and IL-1β in brain-dead donor rats ［J］. J Chengdu Med Coll， 2020， 15（1）： 40-45.
25. 25.
    SUN X， WANG X， HE Q， et al. Investigation of the ameliorative effects of baicalin against arsenic trioxide-induced cardiac toxicity in mice ［J］. Int Immunopharmacol， 2021， doi： .
26. 26.
    WANG M， WANG H Y. Protective effect of stigma maydis palysaccharide preconditioning on ischemia-reperfusion myocardial injury in rats ［J］. Chin J Lab Diagn， 2020， 24（8）： 1315-1318.
27. 27.
    YANG Y， GUAN Q B， GUO L， et al. Protective mechanism of polysaccharides from anoderma camphora on acute liver injury in mice ［J］. Chin J Mod Appl Pharm， 2019， 36（14）： 1767-1772.
28. 28.
    WANG Q W， LUO Q， XU Y Y， et al. Protective effect and mechanism of rosa roxburghii tratt polysaccharides on isoprenaline-induced myocardial ischemia in mice ［J］. Food Sci， 2024， 45（5）： 78-85.
29. 29.
    ZENG B， LIAO X， LIU L， et al. Thyroid hormone diminishes Ca²⁺ overload induced by hypoxia/reoxygenation in cardiomyocytes by inhibiting late sodium current and reverse-Na⁺/Ca²⁺ exchange current ［J］. Pharmacology， 2020， 105（1/2）： 63-72.
30. 30.
    CHEN S， LI S. The Na⁺/Ca²⁺ exchanger in cardiac ischemia/reperfusion injury ［J］. Med Sci Monit， 2012， 18（11）： Ra161-165.
31. 31.
    WANG L， CHEN X， WANG Y， et al. MiR-30c-5p mediates the effects of Panax notoginseng saponins in myocardial ischemia reperfusion injury by inhibiting oxidative stress-induced cell damage ［J］. Biomed Pharmacother， 2020， doi： .
32. 32.
    YE J H， SHEN S H， ZHANG T J， et al. Angelica sinensis polysaccharide ameliorates MIRI in rats in vitro and its mechanism ［J］. Shandong Med J， 2023， 63（29）： 45-50.
33. 33.
    FAN Z J， XIE L T， CUI J， et al. APS post-treatment protects against myocardial ischemia/reperfusion injury by inhibiting mitochondrial damage-mediated apoptosis ［J］. Liaoning J Tradit Chin Med， 2018， 45（7）： 1357-1360.
34. 34.
    WU H， LIU Y， HAO Y， et al. Lycium barbarum polysaccharide protects cardiomyocytes from hypoxia/reoxygenation injury via activation of SIRT3/CypD signaling ［J］. Ann Transl Med， 2023， 11（2）： 72.
35. 35.
    WANG Y C， ZHANG Y T， WANG J J. Protective effect of Lycium barbarum polysaccharide on myocardial ischemia-reperfusion injury in rats ［J］. Shandong Med J， 2013， 53（5）： 34-35.
36. 36.
    MARINESCU M C， LAZAR A L， MARTA M M， et al. Non-coding RNAs： Prevention， diagnosis， and treatment in myocardial ischemia-reperfusion injury ［J］. Int J Mol Sci， 2022， 23（5）： 2728.
37. 37.
    CHEN Z， WU J， LI S， et al. Inhibition of myocardial cell apoptosis is important mechanism for ginsenoside in the limitation of myocardial ischemia/reperfusion injury ［J］. Front Pharmacol， 2022， doi： .
38. 38.
    MORRIS J L， GILLET G， PRUDENT J， et al. Bcl-2 family of proteins in the control of mitochondrial calcium signalling： An old chap with new roles ［J］. Int J Mol Sci， 2021， 22（7）： 3730.
39. 39.
    HUANG L F， LIU C Q. Effects of astragalus polysaccharides on rats with myocardial ischemia-reperfusion injury based on NRG-1/ErbB signaling pathway ［J］. Chin J Integr Med Cardio-cardiovascular Dis， 2023， 21（18）： 3351-3356.
40. 40.
    SUN B， WAN L， LIN X J， et al. Study on the inhibitory effects of Pseudostellaria heterophylla polysaccharide on myocardial apoptosis of ischemia-reperfusion injury model rats ［J］. China Pharm， 2018， 29（16）： 2175-2179.
41. 41.
    FAN W， HUANG Y， ZHENG H， et al. Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases： Pharmacology and mechanisms ［J］. Biomed Pharmacother， 2020， doi： .
42. 42.
    SAITO T， SADOSHIMA J. Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart ［J］. Circ Res， 2015， 116（8）： 1477-1490.
43. 43.
    ZHOU H， HU S， JIN Q， et al. Mff-dependent mitochondrial fission contributes to the pathogenesis of cardiac microvasculature ischemia/reperfusion injury via induction of mROS-mediated cardiolipin oxidation and HK2/VDAC1 disassociation-involved mPTP opening ［J］. J Am Heart Assoc， 2017， 6（3）： e005328.
44. 44.
    AJOOLABADY A， CHIONG M， LAVANDERO S， et al. Mitophagy in cardiovascular diseases： Molecular mechanisms， pathogenesis， and treatment ［J］. Trends Mol Med， 2022， 28（10）： 836-849.
45. 45.
    MA X G， ZHAO S C， LI S X. Effects of red ginseng polysaccharide on myocardial fibrosis and mitochondrial energy metabolism in mice with coronary heart disease ［J］. Chin J Evid Cardiovasc， 2023， 15（6）： 740-744，748.
46. 46.
    YANG W S， STOCKWELL B R. Ferroptosis： Death by lipid peroxidation ［J］. Trends Cell Biol， 2016， 26（3）： 165-176.
47. 47.
    YAN H F， TUO Q Z， YIN Q Z， et al. The pathological role of ferroptosis in ischemia/reperfusion-related injury ［J］. Zool Res， 2020， 41（3）： 220-230.
48. 48.
    WU J R， TUO Q Z， LEI P. Ferroptosis， a recent defined form of critical cell death in neurological disorders ［J］. J Mol Neurosci， 2018， 66（2）： 197-206.
49. 49.
    ZHANG L B， YANG Y， WANG D S. Inhibitory effect of seaweed polysaccharide on cardiomyocyte injury and ferroptosis induced by hydroperoxide through regulating pathway of nuclear factor E₂ related factor 2 ［J］. Chin J Evid Cardiovasc， 2023， 15（6）： 712-715，720.
50. 50.
    LIU H， LI H Z， ZHANG H， et al. Effects of Polygona-polysaccharose on ferroptosis in diabetic nephropathy rats ［J］. Chin J Inf Tradit Chin Med， 2023， 30（8）： 126-130.
51. 51.
    YUAN J， MO H， LUO J， et al. PPARα activation alleviates damage to the cytoskeleton during acute myocardial ischemia/reperfusion in rats ［J］. Mol Med Rep， 2018， 17（5）： 7218-7226.
52. 52.
    SZABó P L， DOSTAL C， PILZ P M， et al. Remote ischemic perconditioning ameliorates myocardial ischemia and reperfusion-induced coronary endothelial dysfunction and aortic stiffness in rats ［J］. J Cardiovasc Pharmacol Ther， 2021， 26（6）： 702-713.
53. 53.
    KUNDUMANI-SRIDHARAN V， SUBRAMANI J， OWENS C， et al. Nrg1β released in remote ischemic preconditioning improves myocardial perfusion and decreases ischemia/reperfusion injury via ErbB2-mediated rescue of endothelial nitric oxide synthase and abrogation of Trx2 autophagy ［J］. Arterioscler Thromb Vasc Biol， 2021， 41（8）： 2293-2314.
54. 54.
    SHIRAISHI M， YAMAGUCHI A， SUZUKI K. Nrg1/ErbB signaling-mediated regulation of fibrosis after myocardial infarction ［J］. FASEB J， 2022， 36（2）： e22150.
55. 55.
    MENEZES-RODRIGUES F S， ERRANTE P R， ARAÚJO E A， et al. Cardioprotection stimulated by resveratrol and grape products prevents lethal cardiac arrhythmias in an animal model of ischemia and reperfusion ［J］. Acta Cir Bras， 2021， 36（3）： e360306.
56. 56.
    HOTZ P W， WIESNET M， TASCHER G， et al. Profiling the murine SUMO proteome in response to cardiac ischemia and reperfusion injury ［J］. Molecules， 2020， 25（23）： 5571.
57. 57.
    VINCENT A， COVINHES A， BARRèRE C， et al. Acute and long-term cardioprotective effects of the traditional Chinese medicine MLC901 against myocardial ischemia-reperfusion injury in mice ［J］. Sci Rep， 2017， 7（1）： 14701.
58. 58.
    RAWLINGS N， LEE L， NAKAMURA Y， et al. Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury ［J］. PLoS One， 2019， 14（4）： e0213331.
59. 59.
    CHANG X， LI H L， CHU S F， et al. Astragalus polysaccharide reduces myocardial tissue apoptosis through NRG-1/ErbB signal pathway in rats ［J］. J Basic Chin Med， 2016， 22（9）： 1192-1195，1218.
60. 60.
    ZHANG K J， WANG Y Q， CHU Q G， et al. Influence of Didang Xianxiong decoction on apoptosis of podocytes in diabetes rats through PI3K/Akt signaling pathway ［J］. Chin J Exp Tradit Med Formulae， 2024， 30（12）： 62-69.
61. 61.
    FORINI F， NICOLINI G， IERVASI G. Mitochondria as key targets of cardioprotection in cardiac ischemic disease： Role of thyroid hormone triiodothyronine ［J］. Int J Mol Sci， 2015， 16（3）： 6312-6336.
62. 62.
    YUE Z R， ZHANG Y， TANG J C， et al. Icariin regulates glucocorticoid-induced autophagy of bone microvascular endothelial cells through PI3K/Akt/mTOR pathway ［J］. Chin J Exp Tradit Med Formulae， 2024， 30（15）： 73-80.
63. 63.
    ZHANG Y N， LU H F， WANG P， et al. Shenghui granules improve learning memory in Alzheimer's disease mice by inhibiting PI3K/Akt/mTOR signaling pathway ［J］. Chin J Integr Tradit West Med， 2024， 44（3）： 324-330.
64. 64.
    CHEN Q Y， SUN Y， GAO C H， et al. Effects of Hedysarum polybotys polysaccharide on isoproterenol-induced mouse myocardial hypertrophy via PI3K/Akt signaling pathway ［J］. Chin Tradit Pat Med， 2023， 45（11）： 3598-3603.
65. 65.
    TONELLI C， CHIO I I C， TUVESON D A. Transcriptional regulation by Nrf2 ［J］. Antioxid Redox Signal， 2018， 29（17）： 1727-1745.
66. 66.
    CHANG C， CAI R P， SU Y M， et al. Mesenchymal stem cell-derived exosomal noncoding RNAs as alternative treatments for myocardial ischemia-reperfusion injury： Current status and future perspectives ［J］. J Cardiovasc Transl Res， 2023， 16（5）： 1085-1098.
67. 67.
    SONI D， KUMAR P. GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders ［J］. Pharmacol Rep ： PR， 2022， 74（4）： 557-569.
68. 68.
    XU J， ZHU K， WANG Y， et al. The dual role and mutual dependence of heme/HO-1/Bach1 axis in the carcinogenic and anti-carcinogenic intersection ［J］. J Cancer Res Clin Oncol， 2023， 149（1）： 483-501.
69. 69.
    ZHENG T. Study on the improvement of myocardial ischemia-reperfusion injury based on Nrf2/HO-1/NLRP3 signaling pathway by ethanol extract of Taraxacum mongolicum Hand-Mazz and dandelion polysaccharide ［D］. Yanbian： Yanbian University， 2022.
70. 70.
    JANSEN T， KVANDOVá M， DAIBER A， et al. The AMP-activated protein kinase plays a role in antioxidant defense and regulation of vascular inflammation ［J］. Antioxidants （Basel）， 2020， 9（6）： 525.
71. 71.
    DENGLER F. Activation of AMPK under hypoxia： Many roads leading to rome ［J］. Int J Mol Sci， 2020， 21（7）： 2428.
72. 72.
    LIU Y， CAI M H， WANG C， et al. Effects of capsaicin on cardiac function and miR-34a/SIRT1 axis in rats with myocardial ischemia-reperfusion injury ［J］. Chin J Gerontol， 2023， 43（8）： 1894-1899.
73. 73.
    ZHANG X， YU Y， LEI H， et al. The Nrf-2/HO-1 signaling axis： A ray of hope in cardiovascular diseases ［J］. Cardiol Res Pract， 2020， doi： .
74. 74.
    NIU X W. Angelica sinensis polysaccharide protects against myocardial ischemia/reperfusion injury via Oip5-as1 mediated SIRT1-AMPK-PGC1α pathway ［D］. Lanzhou： Lanzhou University， 2019.
75. 75.
    LIU Y J， ZHANG Y Q， FANG Y L， et al. Regulation of SIRT1/AMPK/PGC-1α signaling pathway by Polygonatum polysaccharide improves H₂O₂-induced oxidative damage in HT22 cells ［J］. Chin J Mod Appl Pharm， 2021， 38（16）： 1952-1957.
76. 76.
    ZHANG X， FU L J. The study of salvianolic acid B on the improvement of myocardial fibrosis in diabetic rats by RhoA/ROCK1 pathway ［J］. Chin Pharmacol Bull， 2022， 38（10）： 1487-1491.
77. 77.
    CROSAS-MOLIST E， SAMAIN R， KOHLHAMMER L， et al. Rho GTPase signaling in cancer progression and dissemination ［J］. Physiol Rev， 2022， 102（1）： 455-510.
78. 78.
    LEE T M， LIN S Z， CHANG N C. Membrane ERα attenuates myocardial fibrosis via RhoA/ROCK-mediated actin remodeling in ovariectomized female infarcted rats ［J］. J Mol Med （Berl）， 2013， 92（1）： 43-51.
79. 79.
    SHEN Y L， LIU C H， WANG S K， et al. Experimental study of baicalin alleviating hypoxia-induced H9c2 cell injury through ROS-dependent Rho A/ROCK pathway ［J］. J Hainan Med Univ， 2024， 30（7）： 481-488.
80. 80.
    XING X P， REN C Z， JIANG H G， et al. Study on mechanism of angelica and hedysari polysaccharide on radiation-induced H9C2 cardiac cells based on Rho/Rock pathway ［J］. Liaoning J Tradit Chin Med， 2021， 48（7）： 228-231，262.
81. 81.
    SHINDE M Y， SIDOLI S， KULEJ K， et al. Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing ［J］. J Biol Chem， 2017， 292（44）： 18240-18255.
82. 82.
    DONG X Y， REN J， SHENG J Z. Research on development of pathogenic mechanism of GSK-3β and influence in related diseases ［J］. Prog Physiol Sci， 2018， 49（2）： 87-91.
83. 83.
    LIU X Y， GU M H， XU Y L， et al. Dingxin recipe Ⅰ prevents myocardial ischemia reperfusion injury through GSK3β/Nrf2/HO-1 pathway ［J］. Tradit Chin Drug Res Clin Pharmacol， 2020， 31（11）： 1265-1270.
84. 84.
    FARHAT F， NOFAL S， RAAFAT E M， et al. Akt / GSK3β / Nrf2 / HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity ［J］. Neuropharmacology， 2021， 196： 108654.
85. 85.
    SONG J H， ZHANG L， CHEN H B. To study the protective effect of polysaccharide from Chinese yam on myocardial cell injury induced by high glucose based on Wnt/β-catenin ［J］. Chin Tradit Pat Med， 2023， 45（2）： 626-629.
86. 86.
    NIU S M， WANG L P， YANG Y T， et al. Myocardial remodeling and protective effects of ganoderma lucidum polysaccharide based on p-Akt/p-GSK3β/GSK3β pathway in diabetic rats ［J］. Anhui Med Pharm J， 2023， 27（12）： 2361-2366.
87. 87.
    YANG J， LI Y， ZENG L， et al. Traditional Chinese medicine against fibrotic diseases： A review ［J］. Chin J Exp Tradit Med Form， 2024， 30（3）： 270-278.
88. 88.
    ZHANG J Q， GUO J， CHEN Y X， et al. Regulation of lung cancer-related signaling pathways by Chinese medicine： A review ［J］. Chin J Exp Tradit Med Form， 2024， 30（19）： 233-244.
89. 89.
    ZHOU Q， ZHANG M F， REN H Y， et al. Effect of hydrogen sulfide intervention on the expression of MAPK pathway in myocardial fibrosis in mice ［J］. Chin J Gerontol， 2018， 38（12）： 2981-2984.
90. 90.
    CAO J， QIN G， SHI R， et al. Overproduction of reactive oxygen species and activation of MAPKs are involved in apoptosis induced by PM_2.5 in rat cardiac H9c2 cells ［J］. J Appl Toxicol， 2016， 36（4）： 609-617.
91. 91.
    ZOU Y， XIAO M， MENG Y H， et al. Effect and mechanism of action of epimedii folium polysaccharides on mice with exercise-induced fatigue based on p38 MAPK/NF-κB signaling pathway ［J］. Chin J Exp Tradit Med Form， 2024， 30（10）： 20-28.
92. 92.
    HUANG Q， LIN P H， ZHENG D D， et al. Study on the effects of prophylactic administration of ramulus mori polysaccharides on inflammatory responses of renal ischemia reperfusion injury model mice and its mechanism ［J］. China Pharm， 2019， 30（13）： 1786-1791.
93. 93.
    SANTOS-GALLEGO C G， REQUENA-IBANEZ J A， SAN ANTONIO R ， et al. Empagliflozin ameliorates adverse left ventricular remodeling in nondiabetic heart failure by enhancing myocardial energetics ［J］. J Am Coll Cardiol， 2019， 73（15）： 1931-1944.
94. 94.
    LI D N， Y B. Mechanism of bone marrow mesenchymal stem cells in treatment of cardiovascular diseases complicated by psychological disorder ［J］. Chin J Evid Cardiovasc Med， 2019， 11（10）： 1267-1269.
95. 95.
    LOPASCHUK G D. Metabolic modulators in heart disease： Past， present， and future ［J］. Can J Cardiol. 2017， 33（7）： 838-849.
96. 96.
    SUN H， LU Y. Regulation of Portulaca oleracea polysaccharide on cardiac energy metabolism in rats ［J］. Cereals Oils， 2018， 31（7）： 94-97.
97. 97.
    FILLMORE N， WAGG CS， ZHANG L， et al. Cardiac branched-chain amino acid oxidation is reduced during insulin resistance in the heart ［J］. Am J Physiol Endocrinol Metab， 2018， 315（5）： E1046-E1052.
98. 98.
    WANG J， XUE Z， HUA C， et al. Metabolomic analysis of the ameliorative effect of enhanced proline metabolism on hypoxia-induced injury in cardiomyocytes ［J］. Oxid Med Cell Longev， 2020， doi： .
99. 99.
    HUANG H， HUANG L J， ZHONG A H， et al. Extraction technology of polysaccharide from euryale ferox salisb by response surface methodology and antioxidant activity in vitro ［J］. Food Ferment Sci Technol， 2024， 60（2）： 26-33，71.
100. 100.
     REN D， FEDOROVA J， DAVITT K， et al. Activated protein C strengthens cardiac tolerance to ischemic insults in aging ［J］. Circ Res， 2022， 130（2）： 252-272.
101. 101.
     AA N， LU Y， YU M， et al. Plasma metabolites alert patients with chest pain to occurrence of myocardial infarction ［J］. Front Cardiovasc Med， 2021， doi： .
102. 102.
     ZHENG P， XIE Z， YUAN Y， et al. Plin5 alleviates myocardial ischaemia/reperfusion injury by reducing oxidative stress through inhibiting the lipolysis of lipid droplets ［J］. Sci Rep， 2017， doi： .
103. 103.
     ZHANG L， DAI Z， GUO R， et al. Metabolomics reveal dynamic changes in eicosanoid profile in patients with ST-elevation myocardial infarction after percutaneous coronary intervention ［J］. Clin Exp Pharmacol Physiol， 2021， 48（4）： 463-470.
104. 104.
     GUO M， FAN X， TUERHONGJIANG G， et al. Targeted metabolomic analysis of plasma fatty acids in acute myocardial infarction in young adults ［J］. Nutr Metab Cardiovasc Dis， 2021， 31（11）： 3131-3141.
105. 105.
     HUANG A， FANG X Y， HE W W， et al. Research progress in Danshen（Salviae Miltiorrhizae Radix et Rhizoma） in regulation of glucose and lipid metabolism ［J］. Cent South Pharm， 2024， 22（3）： 733-741.
106. 106.
     CAI W B， ZHAO Y J， LIU L， et al. Redox environment metabolomic evaluation （REME） of the heart after myocardial ischemia/reperfusion injury ［J］. Free Radic Biol Med， 2021， 173： 7-18.