تأثير تنظيمي تتالي للأكسدة والخلوت الخلويل لعقار هي شياو ياو تسان على حماية الأعصاب للجرذان المصابة بمرض الزهايمر

  • role: First author第一作者
  • Affiliation:

    Gansu University of Chinese Medicine, Lanzhou 730000, China

  • Email:1513111208@qq.com
  • Introduction:E-mail1513111208@qq.com
CHEN Yiqin1,  
  • Affiliation:

    Gansu University of Chinese Medicine, Lanzhou 730000, China

YANG Jiao1,  
  • Affiliation:

    Gansu University of Chinese Medicine, Lanzhou 730000, China

PEI Wenli1,  
  • Affiliation:

    Gansu University of Chinese Medicine, Lanzhou 730000, China

HAN Yumei1,  
  • role: Corresponding author通信作者
  • Affiliation:

    Gansu University of Chinese Medicine, Lanzhou 730000, China

    Gansu Key Laboratory of Traditional Chinese Medicine(TCM) Excavation and Innovative Transformation,Lanzhou 730000, China

    Gansu Engineering Laboratory for New Products of TCM, Lanzhou 730000, China

  • Email:whp@gszy.edu.cn
  • Introduction:E-mailwhp@gszy.edu.cn
WANG Huping123*

ملخص

الغرض من الدراسة هو التحقيق في دور وآلية التأثير الوظيفي للطريقة الراسية لمساعدة حماية الخلايا ومنع مرض الزهايمر (AD) من خلال روابط تنظيمية تتالية لمساهمة مسار نشاط البروتين الحيوي B (Akt) / الانزيم المحفز لتخليق الجليكوجين-3 β (GSK-3 β ) / عامل 2 ذات الصلة بالحمض النووي E (Nrf2) / هيموكسيجين -1 (HO-1).

مفهوم

هي شياو ياو تسان; مرض الزهايمر; البروتين الحيوي B (Akt) / الانزيم المحفز لتخليق الجليكوجين-3 β (GSK-3 β ) / عامل 2 ذات الصلة بالحمض النووي E (Nrf2) / هيموكسيجين -1 (HO-1); الخلوت الخلويل; الأكسدة

References

  1. 1.
    KANEKAR S,POOT J D. Neuroimaging of vascular dementia [J]. Radiol Clin North Am,2014, 52(2): 383-401
  2. 2.
    GUO R W,XIE W J,YU B,et al. Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer's disease mice[J].Zool Res,2024,45 (4):924-936.
  3. 3.
    MARTÍNEZ-IGLESIAS O,NAIDOO V,CARRIL J C,et al. Gene expression profiling as a novel diagnostic tool for neurodegenerative disorders[J].Int J Mol Sci,2023,24 (6):5746.
  4. 4.
    CORRIVEAU-LECAVALIER N,MACHULDA M M,BOTHA H,et al. Phenotypic subtypes of progressive dysexecutive syndrome due to Alzheimer's disease:A series of clinical cases[J].J Neurol,2022,269 (8):4110-4128.
  5. 5.
    CUI L,HOU N N,WU H M,et al. Prevalence of Alzheimer's disease and Parkinson's disease in China:An updated systematical analysis[J].Front Aging Neurosci,2020,12:603854.
  6. 6.
    LI X,FENG X,SUN X,et al. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2019[J].Front Aging Neurosci,2022,14:937486.
  7. 7.
    MATTAP S M,MOHAN D,MCGRATTAN A M,et al. The economic burden of dementia in low- and middle-income countries (LMICs):A systematic review[J].BMJ Glob Health,2022,7(4):e007409.
  8. 8.
    AGRAWAL N,SKELTON A A. Structure and function of Alzheimer's amyloid β proteins from monomer to fibrils:A mini review[J].Protein J,2019,38 (4):425-434.
  9. 9.
    BUTTERFIELD D A,BOYD-KIMBALL D.Oxidative stress,amyloid-β peptide,and altered key molecular pathways in the pathogenesis and progression of Alzheimer's disease[J].J Alzheimers Dis,2018,62 (3):1345-1367.
  10. 10.
    CUI W,ZHANG Y,YANG C,et al.Hydrogen sulfide prevents Abeta-induced neuronal apoptosis by attenuating mitochondrial translocation of PTEN[J].Neuroscience,2016,325:165-174.
  11. 11.
    ALI T, KIM T, REHMAN S U, et al.Natural dietary supplementation of anthocyanins via PI3K/Akt/Nrf2/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse model of Alzheimer's disease [J]. Mol Neurobiol, 2018, 55(7): 6076-6093.
  12. 12.
    SONG M,ZHANG S,YU W,et al. Gomisin N rescues cognitive impairment of Alzheimer's disease by targeting GSK-3β and activating Nrf2 signaling pathway[J].Phytomedicine,2024,132:155811.
  13. 13.
    HUANG Q Q.Ferula improves oxidative stress and apoptosis by regulating the PI3K/Akt/GSK-3β/Nrf2/HO-1 pathway, exerting neuroprotective effects[D].Beijing:Beijing University of Chinese Medicine,2022.
  14. 14.
    ZHANG C H,WEI J H.Studies on flurbiprofen exate modulating Akt/GSK-3β/Nrf2/HO-1 signaling pathways to ameliorate H/R-induced neuronal damage[J].World Clin Drug,2023,44(6):567-573,637.
  15. 15.
    FARHAT F,NOFAL S,RAAFAT E M,et al. Akt/GSK-3β/Nrf2/HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity[J].Neuropharmacology,2021,196:108654.
  16. 16.
    HU Y Y, LYU Y J, MENG Z P,et al. Hei Xiaoyaosan affects synaptic plasticity of hippocampal neurons in APP/PS1 double transgenic mice of AD via cAMP/PKA/NMDAR signaling pathway[J].Chin J Exp Tradit Med Form, 2024,30(17):27-34.
  17. 17.
    LI M C, ZHOU J, HU Y Y, et al. Heixiaoyao powder interferes with microglia polarization in AD model mice by regulating NOX2/ROS/NF-κB signaling pathway[J]. China J Chin Mater Med, 2023,48(15): 4027-4038.
  18. 18.
    LI X, HU Y M, WEI C X, et al. Effect of Hei Xiaoyaosan on neuroinflammation in AD model rats:Based on Wnt/β-catenin signaling pathway[J].Chin J Exp Tradit Med Form, 2022, 28(11): 33-41.
  19. 19.
    LYU Y J, HU Y Y, MENG Z P, et al. Hei Xiaoyaosan in treating Alzheimer's disease:A review[J].Chin J Exp Tradit Med Form, 2024,30(17):43-50.
  20. 20.
    MI C Y, PENG C, ZHOU J, et al. The effect of Hei Xiaoyaosan regulating the p38 MAPK/ATF2/COX-2 signaling pathway on neuroinflammation in Alzheimer's disease rats[J].Chin Tradit Pat Med, 2024, 46(2): 590-595.
  21. 21.
    WANG H P, CHEN Y Q, YANG J, et al. Hei Xiaoyaosan regulates Fas/FasL/Caspase-8/Caspase-3 signaling pathway to inhibit neuronal apoptosis in AD rats[J]. Chin J Exp Tradit Med Form, 2024,30(17):18-26.
  22. 22.
    WANG H P, HU Y Y, LYU Y J, et al. Effect of Hei Xiaoyaosan regulating p38 MAPK/Beclin-1/Bcl-2 pathway on autophagy level in Alzheimer's disease model rats[J]. China J Chin Mater Med, 2024, 49(12): 3348-3355.
  23. 23.
    WANG H P, HU Y Y, LYU Y J, et al. Effect of Hei Xiaoyaosan regulating p38 MAPK/Beclin-1/Bcl-2 pathway on autophagy level in Alzheimer's disease model rats[J]. Chin J Exp Tradit Med Form, 2024, 30(17):35-42.
  24. 24.
    WANG H P, YANG J, CHEN Y Q. Exploring improvement effect of Hei Xiaoyao San on learning and memory ability in Alzheimer's disease rats based on mechanism of cell apoptosis[J].Chin J Exp Tradit Med Form,2025,doi:.
  25. 25.
    YANG J, CHEN Y Q, PEI W L, et al.Hei Xiaoyaosan inhibits ferroptosis by regulating SIRT1/p53/SLC7A11 signaling pathway to ameliorate cognitive dysfunction in rat model of AD[J].Chin J Exp Tradit Med Form,2025,doi:.
  26. 26.
    WANG H P, MI C Y, ZHOU J, et al. Intervention of Hei Xiaoyaosan in Alzheimer's disease immune inflammation based on liver-kidney homology[J].Chin J Exp Tradit Med Form, 2022,28(17):180-187.
  27. 27.
    WANG H P, MI C Y, ZHOU J, et al. The improvement effect of Hei Xiaoyao San on Alzheimer's disease rats by regulating the PP2A/GSK-3β pathway[J].Chin Tradit Pat Med, 2022,44(10):3311-3314.
  28. 28.
    ZHOU J,LI M C,LYU Y J,et al.Effect of Hei Xiaoyaosan on neuroinflammation and NLRP3/Caspase-1/GSDMD signaling pathway in APP/PS1 mice[J].Chin J Exp Tradit Med Form,2025,doi:.
  29. 29.
    HUANG H Y,SALINAS S,CORNELL J,et al.CCR5 regulates Aβ1-42-induced learning and memory deficits in mice[J].Neurobiol Learn Mem,2024,208:107890.
  30. 30.
    ZHUGE Q C, The rat brain in stereotaxic coordinates[M]. Beijing: People's Medical Publishing House, 2005:16-20.
  31. 31.
    XU S Y,BIAN R L,CHEN X.Methodology of pharmacological experiment[M].Beijing: People's Medical Publishing House, 2002:202-203.
  32. 32.
    FENG Y,WANG X.Antioxidant therapies for Alzheimer's disease[J].Oxid Med Cell Longev, 2012,2012:472932.
  33. 33.
    WU Y F,XU L L,DI B, et al. Application of Nrf2 activators in the treatment of Alzheimer's disease[J].J China Pharm Univ,2019,50(6):648-658.
  34. 34.
    PERSSON T,POPESCU B O,CEDAZO-MINGUEZ A. Oxidative stress in Alzheimer's disease:Why did antioxidant therapy fail?[J].Oxid Med Cell Longev,2014,2014:427318.
  35. 35.
    SINGH A,KUKRETI R,SASO L,et al. Oxidative stress: A key modulator in neurodegenerative diseases[J].Molecules,2019,24 (8):1583.
  36. 36.
    MATSUDA S,IKEDA Y,MURAKAMI M,et al. Roles of PI3K/Akt/GSK-3 pathway involved in psychiatric illnesses[J].Diseases,2019,7 (1):22.
  37. 37.
    LI D D,WANG X H,CHEN J. Research progress on the use of traditional Chinese medicine monomers to regulate the PI3K/Akt signaling pathway in the treatment of Alzheimer's disease[J].Acta Chin Med,2024,doi:.
  38. 38.
    KOISTINAHO J,MALM T,GOLDSTEINS G. Glycogen synthase kinase-3β:A mediator of inflammation in Alzheimer's disease?[J].Int J Alzheimers Dis,2011,2011:129753.
  39. 39.
    ZHANG J,LI Q,ZHOU Y Y. Regulation of Nrf2 pathway by traditional Chinese medicine in prevention and treatment of Alzheimer's disease:A review[J].Chin J Exp Tradit Med Form, 2024,30(9):219-227.
  40. 40.
    SCHIEBER M,CHANDEL N S.ROS function in redox signaling and oxidative stress[J].Curr Biol,2014,24(10):R453-R462.
  41. 41.
    GU Z R,XU A X,LI F, et al. Progress of central neuroprotective effects of TCMs and its active constituents based on PI3K/Akt signaling pathway[J]. Chin J New Drugs,2019,28(13):1593-1599.

قراءة النص الكامل

The above content is generated by Large Model Translation. The translated content is for reference only. We do not assume any commercial or legal responsibilty for any consequences arising from the use of our website