تنظيم إشارات Nrf2/SLC7A11/GPX4 بمستخلص Angi Shaoyao San للتدخل في وفاة الحديد في الكبد الدهني غير الكحولي للفئران

  • role: First author第一作者
  • Affiliation:

    Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China

  • Email:1092331044@qq.com
  • Introduction:E-mail1092331044@qq.com
CHU Xinqiao1,  
  • Affiliation:

    College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang 050200, China

    International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei Province, Shijiazhuang 050200, China

BIAO Yaning23,  
  • Affiliation:

    College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang 050200, China

    International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei Province, Shijiazhuang 050200, China

GU Ying23,  
  • Affiliation:

    Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China

LI Meng1,  
  • Affiliation:

    Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China

JIANG Tiantong1,  
  • Affiliation:

    Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China

DING Yuan1,  
  • Affiliation:

    Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China

TAO Xiaping1,  
  • Affiliation:

    Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China

WANG Shaoli1,  
  • Affiliation:

    The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China

WEI Ziheng4,  
  • role: Corresponding author通信作者
  • Affiliation:

    Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China

  • Email:doctorliuzhen@126.com
  • Introduction:E-maildoctorliuzhen@126.com
LIU Zhen1*,  
  • role: Corresponding author通信作者
  • Affiliation:

    College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang 050200, China

    International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei Province, Shijiazhuang 050200, China

  • Email:hbzyx123@163.com
  • Introduction:E-mailhbzyx123@163.com
ZHANG Yixin23*

ملخص

غرض هذا البحث هو مراقبة تأثير مستخلص Angi Shaoyao San على وفاة الكبد بعد الحديد في الفئران غير الكحولية الدهنية (NAFLD)، واستكشاف آلية عملها استنادًا إلى مسار إشاري نووي E2 ذو الصلة (Nrf2) / عضو عائلة 7 لحاملات الذرات (SLC7A11) / إنزيم غلوتاثيون بيروكسيداز 4 (GPX4).

مفهوم

عشبة Angi Shaoyao San؛ مرض الكبد الدهني غير الكحولي؛ وفاة الحديد؛ عضو العائلة E2 ذو الصلة (Nrf2) / عضو عائلة 7 لحاملات الذرات (SLC7A11) / إنزيم غلوتاثيون بيروكسيداز 4 (GPX4)

References

  1. 1.
    XU Y L, ZHAO J X, YANG L G. Epidemic status and risk factors of non-alcoholic fatty liver disease[J].Chin Gen Pract, 2024, 27(30): 3825-3834.
  2. 2.
    MUNDI M S,VELAPATI S,PATEL J,et al. Evolution of NAFLD and its management[J].Nutr Clin Pract,2020,35 (1):72-84.
  3. 3.
    LOOMBA R,FRIEDMAN S L,SHULMAN G I. Mechanisms and disease consequences of nonalcoholic fatty liver disease[J].Cell,2021,184 (10):2537-2564.
  4. 4.
    FOLGUERAS A R,FREITAS-RODRÍGUEZ S,RAMSAY A J,et al.Matriptase-2 deficiency protects from obesity by modulating iron homeostasis[J].Nat Commun,2018,9(1):1350.
  5. 5.
    HUANG C,FANG X G,CHEN L.Impact of atractylodin on ferroptosis in glioma cells by regulating the Nrf2/SLC7A11/GPX4 signaling pathway[J].Hebei Med J,2024,46(3): 325-329.
  6. 6.
    FAN Y, DOU R P, HU J L, et al. Modulation of iron death by Poric acid through Nrf2/SLC7A11/GPX4 signal pathway in the improvement of cognitive impairment of Alzheimer's disease rats[J].Chin Gen Pract, 2024, 27(2): 177-183.
  7. 7.
    BIAO Y N, ZHANG M Q, HAN X, et al. Danggui Shaoyao San regulates Keap1/Nrf2 signaling pathway in rats with nonalcoholic fatty liver disease[J].Pharm Clin Chin Mater Med, 2022, 38(1): 13-18.
  8. 8.
    CHEN Q.Methodologyfor pharmacological research of traditional Chinese medicine[M].Beiing:People's Medical Publishing House, 1993:1103-1104.
  9. 9.
    LIU J J,DAI L,DONG L,et al.Effects of polydatin on nonalcoholic fatty liver and related molecular mechanisms[J]. Chin J Immunol, 2019, 35(10): 1188-1191.
  10. 10.
    XIAO Y X, LIU Y, XU L L, et al. Research progress on the role of ferroptosis in the pathogenesis of non-alcoholic fatty liver disease[J]. Basic Clin Med, 2024, 44(2): 260-264.
  11. 11.
    YE M Q,XUE J D,LI F P,et al.Study on regulation and mechanism of Huazhi Fugan granules onTLR4/NF-κB pathway and fatty iron death in non-alcoholic fatty liver[J]. Mod J Integr Tradit Chin West Med,2021,30(30):3307-3312.
  12. 12.
    YANG L T, XU T, YANG F Q, et al. Effect and mechanism of TFRC on ferroptosis induced by iron overloadin cardiac myocytes of rats[J].Med J Chin People's Liber Army, 2022, 47(8): 781-788.
  13. 13.
    NATARAJ A,GOVINDAN S,RAMANI P,et al. Antioxidant,antitumour, and anticoagulant activities of polysaccharide from calocybe indica (APK2)[J]. Antioxidants (Basel), 2022, 11(9): 1694.
  14. 14.
    TANG W J, LUO Y D, ZHU J R, et al. Icariin ameliorates heart failure by attenuating ferroptosis through theupregulation of the SLC7A11/GPX4 axis[J]. J Zunyi Med Univ, 2024, 47(3): 211-217.
  15. 15.
    YIN D P, GUO Z X. The mechanism of Nrf2 regulating oxidative stress in diabetesnephropathy[J]. Chin J Clin Res, 2023, 36(5): 646-650.
  16. 16.
    YUAN Y, ZHAI Y, CHEN J, et al. Kaempferol ameliorates oxygen-glucose deprivation/reoxygenation-induced neuronal ferroptosis by actvating Nrf2/SLC7A11/GPX4 axis[J]. Biomolecules, 2021, 11(7):923.
  17. 17.
    SUN M Y, QIN H W, LI Y J, et al. Xueguan Ruanhua pills improve atherosclerosis by inhibiting ferroptosis through the Nrf2/xCT/GPX4 pathway[J].J Beijing Univ Tradit Chin Med, 2024, 47(3): 383-393.
  18. 18.
    ZHENG LL,GUO D Z.Effect of Buyang Huanwutang on ferroptosis in diabetic kidney disease mice[J].Chin J Exp Tradit Med Form,2023,29(17):34-41.
  19. 19.
    WANG F F,CHEN B Y,LI Q.Tumulosic acid inhibits oxygen-glucose deprivation/reoxygenation-induced cardiomyocyte ferroptosis by regulating Nrf2/SLC7A11/GPX4 signaling pathway[J].Chin J Integr Med Cardio-Cerebrovascular Dis, 2024, 22(2): 267-273.
  20. 20.
    JIANG X C,TIAN D Z,LIU Q,et al.Shenling Baizhusan improves spermatogenesis in hyperuricemia oligoasthenospermia mice by regulating Nrf2/ARE pathway[J].Chin J Exp Tradit Med Form,2023,29(15):22-30.
  21. 21.
    GAO S L,CAI Q Q,JIN X J,et al. Impacts of icariin on high glucose-induced microglial ferroptosis by regulating Nrf2/SLC7A11/GPX4 signaling pathway[J].Front Pharm Sci, 2022, 25(11): 1878-1883.

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