التقدم البحثي في الآليات الجزيئية للموت المبرمج للخلايا في مرض الانسداد الرئوي المزمن وتدخل الطب الصيني

  • role: First author第一作者
  • Affiliation:

    Tianjin University of Traditional Chinese Medicine(TCM), Tianjin 301617,China

  • Email:1424762138@qq.com
  • Introduction:E-mail1424762138@qq.com
PENG Xin1,  
  • Affiliation:

    The Second Affiliated Hospital of Tianjin University of TCM, Tianjin 300250,China

LI Yunhui2,  
  • Affiliation:

    Tianjin University of Traditional Chinese Medicine(TCM), Tianjin 301617,China

LIANG Lei1,  
  • Affiliation:

    Tianjin University of Traditional Chinese Medicine(TCM), Tianjin 301617,China

LUAN Zheyu1,  
  • Affiliation:

    Tianjin University of Traditional Chinese Medicine(TCM), Tianjin 301617,China

WANG Hanxiao1,  
  • Affiliation:

    Tianjin University of Traditional Chinese Medicine(TCM), Tianjin 301617,China

XU Haotian1,  
  • Affiliation:

    Tianjin University of Traditional Chinese Medicine(TCM), Tianjin 301617,China

DANG Ziming1,  
  • role: Corresponding author通信作者
  • Affiliation:

    The Second Affiliated Hospital of Tianjin University of TCM, Tianjin 300250,China

  • Email:493507647@qq.com
  • Introduction:E-mail493507647@qq.com
FENG Jihong2*

ملخص

مرض الانسداد الرئوي المزمن (COPD) هو مرض مزمن في الجهاز التنفسي يؤثر بشكل خطير على صحة الإنسان على مستوى العالم، ويتميز بمعدل إصابة وإعاقة ووفيات مرتفع، مما يجعل وضع الوقاية والعلاج أكثر تحديًا. آلية حدوث COPD معقدة، ولا تزال الآليات الخلوية والجزيئية الكامنة غير واضحة بالكامل. الموت المبرمج للخلايا (PCD) هو عملية موت خلايا نشطة تحدث بعد تلقي الخلية لإشارة معينة أو تحفيز بعوامل محددة، للحفاظ على استقرار البيئة الداخلية. أظهرت الأبحاث الطبية الحديثة أن اضطرابات أنماط PCD مثل الاستماتة، الاستماتة النخرية، النخر الحُراري، الالتهام الذاتي والموت الحديدي ترتبط ارتباطًا وثيقًا بحدوث وتطور COPD، ويوفر توضيح الآليات الجزيئية لـPCD في COPD منظورًا جديدًا لفهم وعلاج المرض بعمق. تتميز الطب الصيني بقدرتها على التنظيم الكلي، وخلال السنوات الأخيرة، أجريت دراسات عديدة في مجال الطب الصيني تركز على تنظيم الاستماتة، الاستماتة النخرية، النخر الحُراري، الالتهام الذاتي والموت الحديدي لعلاج COPD، وحققت نتائج ملحوظة. لذلك، ستوضح هذه الورقة بشكل منهجي الآليات الجزيئية لـPCD في COPD، وستستعرض آليات التدخل المحتملة و الوضع الراهن لاستخدام الأعشاب الصينية في استهداف PCD لعلاج COPD، بهدف توفير أفكار ومرجع للوقاية السريرية والعلاج والبحوث المتعمقة لـCOPD.

مفهوم

الموت المبرمج للخلايا;مرض الانسداد الرئوي المزمن;الآليات الجزيئية;الطب الصيني;مراجعة

References

  1. 1.
    WANG C,XU J Y,YANG L,et al.Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health[CPH] study):A national cross-sectional study[J].Lancet,2018,391(10131):1706-1717.
  2. 2.
    MURRAY C J L.Findings from the global burden of disease study 2021[J].Lancet,2024,403(10440):2259-2262.
  3. 3.
    Chronic Obstructive Pulmonary Disease Group of Chinese Thoracic Society,Chronic Obstructive Pulmonary Disease Committee of Chinese Association of Chest Physicians.Guidelines for the diagnosis and management of chronic obstructive pulmonary disease (revised version 2021)[J].Chin J Tuberc Respir Dis,2021,44(3):170-205.
  4. 4.
    AGUSTI A,FABBRI L M,SINGH D,et al.Inhaled corticosteroids in COPD:Friend or foe?[J].Eur Respir J,2018,52(6):1801219.
  5. 5.
    YUAN J Y,OFENGEIM D.A guide to cell death pathways[J].Nat Rev Mol Cell Biol,2024,25(5):379-395.
  6. 6.
    CUI Y N,CHEN Y.Programmed cell death and its research progress in chronic obstructive pulmonary disease[J].J Tuberc Lung Dis,2023,4(5):397-406.
  7. 7.
    CHEN Y,LI X H,YANG M F,et al.Research progress on morphology and mechanism of programmed cell death[J].Cell Death Dis,2024,15(5):327.
  8. 8.
    GALLUZZI L,VITALE I,AARONSON S A,et al.Molecular mechanisms of cell death:Recommendations of the nomenclature committee on cell death 2018[J].Cell Death Differ,2018,25(3):486-541.
  9. 9.
    CHEN L,LUO L J,KANG N X,et al.The protective effect of HBO1 on cigarette smoke extract-induced apoptosis in airway epithelial cells[J].Int J Chron Obstruct Pulmon Dis,2020,15:15-24.
  10. 10.
    WANG Y,CHENG C,HUANG F,et al.Investigation of the molecular mechanisms by which lncRNA MEG8 mediate the development of chronic obstructive pulmonary disease by regulating miR-367-3p/PTEN[J].Int J Lab Med,2024,45(13):1595-1601.
  11. 11.
    SONG Q,CHEN P,LIU X M.The role of cigarette smoke-induced pulmonary vascular endothelial cell apoptosis in COPD[J].Respir Res,2021,22(1):39.
  12. 12.
    LI X M,JIANG X H,ZENG R H,et al.Formononetin attenuates cigarette smoke-induced COPD in mice by suppressing inflammation,endoplasmic reticulum stress,and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways[J].Phytother Res,2024,38(3):1278-1293.
  13. 13.
    YANG L,ZHANG Y M,GUO M N,et al.Matrine attenuates lung injury by modulating macrophage polarization and suppressing apoptosis[J].J Surg Res,2023,281:264-274.
  14. 14.
    LEI L Q,DAI Z L.Exploring the improvement effect and mechanism of matrine on chronic obstructive pulmonary disease model rats based on TGF-β1/Smad3 pathway[J].Chin J Immunol,2025,41(6):1401-1406.
  15. 15.
    WEI P,CHEN Z B,WANG C E,et al.Protective function and mechanism of quercetin in chronic obstructive pulmonary disease[J].Chin J Immunol,2019,35(21):2570-2575.
  16. 16.
    LI Y P,LUO B L,ZHANG L,et al.Resveratrol attenuates endoplasmic reticulum stress and alveolar epithelial apoptosis in a rat model of chronic obstructive pulmonary disease[J].Chin J Tuberc Respir Dis,2014,37(1):30-35.
  17. 17.
    DU L F,HU J W,LU L,et al.The improvement of resveratrol on chronic obstructive pulmonary disease rat induced by smoking and lipopolysaccharide and regulation of lung Derlin-1 protein[J].Drugs Clin,2018,33(8):1865-1869.
  18. 18.
    XIE Y Y,YANG D F,WANG L.Crocin inhibits inflammatory response of rats with chronic obstructive pulmonary disease by mediating PGC-1α/SIRT3 signaling pathway[J].J Clin Pulm Med,2020,25(11):1648-1654.
  19. 19.
    ZHANG Y,WU J W,JIANG Q Y,et al.Effects of Qizhi Zhoufei granules on endoplasmic reticulum stress in chronic obstructive pulmonary disease rats[J].Chin J Inf Tradit Chin Med,2025,32(1):106-112.
  20. 20.
    WANG Y,SU N X,PAN S G,et al.Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases[J].Pharm Biol,2020,58(1):878-885.
  21. 21.
    FAN L,LI L,YU X H,et al.Jianpiyifei II granules suppress apoptosis of bronchial epithelial cells in chronic obstructive pulmonary disease via inhibition of the reactive oxygen species-endoplasmic reticulum stress-Ca2+ signaling pathway[J].Front Pharmacol,2020,11:581.
  22. 22.
    YU X H,HU T,MAO Y Q,et al.Mechanism of Jianpi Yifei Ⅱ on protecting lung tissue from apoptosis induced by cigarette smoke exposure combined with LPS instillation[J].Pharmacol Clin Chin Mater Med,2019,35(4):165-169.
  23. 23.
    ZHE Z,LIAO J S,LI W J,et al.Effects of Qingfei granule protecting airway injury of COPD rats by TLR4/NF-κB signaling pathway[J].Shanghai J Tradit Chin Med,2022,56(3):64-73.
  24. 24.
    FU T L,LI X P,TIAN H,et al.Effect of Zijin Bushui ointment on rats with chronic obstructive pulmonary disease based on the miR-30b-5p/BCL2L11 axis and the underlying mechanism[J].Hebei J Tradit Chin Med,2024,46(9):1493-1500.
  25. 25.
    SHI C X,CAO P,WANG Y K,et al.PANoptosis:A cell death characterized by pyroptosis,apoptosis,and necroptosis[J].J Inflamm Res,2023,16:1523-1532.
  26. 26.
    LIU Y P,LIU T,LEI T T,et al.RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)[J].Int J Mol Med,2019,44(3):771-786.
  27. 27.
    HANSON B.Necroptosis:A new way of dying?[J].Cancer Biol Ther,2016,17(9):899-910.
  28. 28.
    LU Z,VAN EECKHOUTTE H P,LIU G,et al.Necroptosis signaling promotes inflammation,airway remodeling,and emphysema in chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2021,204(6):667-681.
  29. 29.
    VAN EECKHOUTTE H P,DONOVAN C,KIM R Y,et al.RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD[J].Eur Respir J,2023,61(4):2201506.
  30. 30.
    ZOU Q,FU D D,FAN T Y,et al.Effects and mechanisms of wogonin on airway inflammation in rats with chronic obstructive pulmonary disease[J].Chin Pharm,2023,34(9):1060-1065.
  31. 31.
    LUAN G X,ZHU Z,WU K Y,et al.Theaflavin-3,3'-digallate attenuates cigarette smoke extract-induced pulmonary emphysema in mice by suppressing necroptosis[J].Exp Ther Med,2022,23(1):11.
  32. 32.
    CHEN Z,LIU G Y,XIE W Y,et al.Mechanism of modified Erchen decoction on COPD inflammation based on TNF-α/TNFR1/RIPKs pathway[J].Chin J Exp Tradit Med Form,2024,30(9):40-47.
  33. 33.
    RAO Z P,ZHU Y T,YANG P,et al.Pyroptosis in inflammatory diseases and cancer[J].Theranostics,2022,12(9):4310-4329.
  34. 34.
    LIU Y F,PAN R J,OUYANG Y Z,et al.Pyroptosis in health and disease:Mechanisms,regulation and clinical perspective[J].Signal Transduct Target Ther,2024,9(1):245.
  35. 35.
    ZHOU J,ZHANG L Y,LIU Y T,et al.Research progress on the role of NLRP3 inflammasome in chronic obstructive pulmonary disease[J].J Clin Pulm Med,2024,29(8):1254-1258.
  36. 36.
    ZHANG M Y,JIANG Y X,YANG Y C,et al.Cigarette smoke extract induces pyroptosis in human bronchial epithelial cells through the ROS/NLRP3/caspase-1 pathway[J].Life Sci,2021,269:119090.
  37. 37.
    WANG L,MENG J,WANG C C,et al.Hydrogen sulfide attenuates cigarette smoke-induced pyroptosis through the TLR4/NF-κB signaling pathway[J].Int J Mol Med,2022,49(5):56.
  38. 38.
    ZOU Q,OUYANG Y,ZOU L L,et al.Influences of morin hydrate on pyroptosis of alveolar epithelial cells in rats with chronic obstructive pulmonary disease by inhibiting NLRP3/Caspase-1/IL-1β signaling pathway[J].Chin J Immunol,2024,40(10):2052-2057.
  39. 39.
    ZENG J M,LIAO S D,LIANG Z,et al.Schisandrin A regulates the Nrf2 signaling pathway and inhibits NLRP3 inflammasome activation to interfere with pyroptosis in a mouse model of COPD[J].Eur J Med Res,2023,28(1):217.
  40. 40.
    WANG W.Discussion on molecular mechanism of glaucocalyxin a intervening COPD based on autophagy and pyroptosis[D].Wuhu:Anhui Polytechnic University,2023.
  41. 41.
    TANG W Y.Study on the effects of salidroside on the pyroptosis of pulmonary tissues in emphysematous mouse[D].Guiyang:Guizhou Medical University,2022.
  42. 42.
    WU B H,YU F C,XIE G Y,et al.Effect and mechanism of Liuwei Buqi formula on pyroptosis in COPD[J].Chin J Integr Tradit Chin West Med,2024,44(5):583-591.
  43. 43.
    ZHANG T G.Shiwei Qingjin decoction inhibits COPD airway inflammation via suppressing Akt mediated bronchial epithelial pyroptosis[D].Guangzhou:Guangzhou University of Chinese Medicine,2023.
  44. 44.
    WU D,WANG X L,GAO Y T,et al.Shenqi Wenfei formula alleviates chronic obstructive pulmonary disease in rats with pulmonary qi deficiency syndrome by regulating NLRP3/GSDMD pyroptosis pathway[J].J South Med Univ,2023,43(9):1500-1508.
  45. 45.
    LIU M,WANG Q Z,LIU Y,et al.Mechanism of compound Tinglizi decoction in improving pulmonary vascular remodeling in COPD-related pulmonary arterial hypertension rats[J].J Hunan Univ Chin Med,2022,42(3):380-386.
  46. 46.
    WU X C,LIU Y,BAI Z P.Compound Tinglizi decoction intervenes COPD-associated pulmonary hypertension through regulation of HMGB1-mediated pyroptosis and immune imbalance[J].Chin J Chin Mater Med,2023,48(11):3055-3065.
  47. 47.
    WU X C,LIU Y,BAI Z P.Intervention mechanism of compound Tinglizi decoction on COPD-PH based on HMGB1-mediated pulmonary artery smooth muscle cell pyroptosis[J].J Liaoning Univ Tradit Chin Med,2025,27(1):12-21.
  48. 48.
    KLIONSKY D J,PETRONI G,AMARAVADI R K,et al.Autophagy in major human diseases[J].EMBO J,2021,40(19):e108863.
  49. 49.
    GALLUZZI L,GREEN D R.Autophagy-independent functions of the autophagy machinery[J].Cell,2019,177(7):1682-1699.
  50. 50.
    XIANG Y L,ZHANG J Q.Tobacco-induced autophagy dysregulation and chronic obstructive pulmonary disease[J].Int J Respir,2024,44(3):255-260.
  51. 51.
    PAN X J,FAN J Q,XIA G Q.Puerarin inhibits alveolar epithelial cell apoptosis in rats with chronic obstructive pulmonary disease by regulating PINK1-parkin signaling pathway-mediated mitophagy[J].Chin J Pathophysiol,2022,38(10):1833-1839.
  52. 52.
    WANG L,JIANG W Z,WANG J,et al.Puerarin inhibits FUNDC1-mediated mitochondrial autophagy and CSE-induced apoptosis of human bronchial epithelial cells by activating the PI3K/Akt/mTOR signaling pathway[J].Aging,2022,14(3):1253-1264.
  53. 53.
    LIU Z,ZENG Y,LI R,et al.Treatment of chronic obstructive pulmonary disease by traditional Chinese medicine Morin monomer regulated by autophagy[J].J Thorac Dis,2024,16(9):6052-6063.
  54. 54.
    GAO Y.The protective effects and mechanisms of hyperoside on PM2.5-induced airway injury and acute exacerbation of COPD in mice[D].Changchun:Jilin University,2021.
  55. 55.
    JIA L D,LIU X F,LIU X G,et al.Bufei Yishen formula protects the airway epithelial barrier and ameliorates COPD by enhancing autophagy through the Sirt1/AMPK/FoxO3 signaling pathway[J].Chin Med,2024,19(1):32.
  56. 56.
    TANG F,LING C H.Curcumin ameliorates chronic obstructive pulmonary disease by modulating autophagy and endoplasmic reticulum stress through regulation of SIRT1 in a rat model[J].J Int Med Res,2019,47(10):4764-4774.
  57. 57.
    LIU M,XIE L,PI M,et al.Effect of Jingui Shenqi pill on inhibition of apoptosis and autophagy of lung tissue through AMPK/mTOR pathway in rats with chronic obstructive pulmonary disease[J].Tianjin J Tradit Chin Med,2021,38(6):782-787.
  58. 58.
    ZHAO M,LI J,WANG G Y,et al.Effect of Qingjin Huatan decoction on COPD rats with phlegm heat stagnation of lung based on Akt/mTOR and beclin-1 signal pathway[J].J Pract Tradit Chin Intern Med,2023,37(5):38-40,153-154.
  59. 59.
    WU L N,ZHAO M,XU G L.Effect of Qingjin Huatan decoction on COPD of rat inflammatory response by regulating autophagy[J].Chin J Exp Tradit Med Form,2019,25(18):30-35.
  60. 60.
    ZHANG Y,XUE X M,MENG L H,et al.Xuanfei Pingchuan capsules ameliorate autophagy in chronic obstructive pulmonary disease by inhibiting p38 phosphorylation[J].Mod J Integr Tradit Chin West Med,2022,31(24):3366-3371.
  61. 61.
    LI D,XUE X M,CAI H Y,et al.Study on the mechanism of Xuanfei Pingchuan capsule in treating autophagy related genes in chronic obstructive pulmonary disease by transcriptome sequencing[J].J Lishizhen Trad Chin Med,2024,35(12):2891-2897.
  62. 62.
    WANG Y Y.Research on mechanism of Shenqi Huatan formula in the treatment of COPD based on mTOR signal pathway regulating autophagy[D].Hefei:Anhui University of Chinese Medicine,2022.
  63. 63.
    LI X D,LIU W,GAO W W,et al.The impact and mechanism of pulmonary and renal replenishing method intervention on cell autophagy in COPD-related pulmonary vascular remodeling via TLR4/NF-κB pathway[J].Guangdong Med J,2024,45(5):553-559.
  64. 64.
    XIE K,LIANG Y J,BIAN Q Q,et al.Mechanism of Bufei Yishen formula in treating COPD on autophagy of A549 cells by PI3K/Akt/mTOR signaling pathway[J].Chin J Tradit Chin Med Pharm,2021,36(4):2294-2298.
  65. 65.
    CHEN X,COMISH P B,TANG D,et al.Characteristics and biomarkers of ferroptosis[J].Front Cell Dev Biol,2021,9:637162.
  66. 66.
    JIN X,TANG J R,QIU X Y,et al.Ferroptosis:Emerging mechanisms,biological function,and therapeutic potential in cancer and inflammation[J].Cell Death Discov,2024,10(1):45.
  67. 67.
    PHILIPPOT Q,DESLÉE G,ADAIR-KIRK T L,et al.Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease[J].PLoS One,2014,9(5):e96285.
  68. 68.
    CHEN Y N,QIN H,ZHAO H.Research progress of iron homeostasis and ferroptosis in chronic obstructive pulmonary disease[J].Chin J Respir Crit Care Med,2024,23(10):756-760.
  69. 69.
    YOSHIDA M,MINAGAWA S,ARAYA J,et al.Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis[J].Nat Commun,2019,10(1):3145.
  70. 70.
    LIU X M,MA Y M,LUO L J,et al.Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway[J].Phytomedicine,2022,96:153894.
  71. 71.
    LIU L,ZHANG Y S,WANG L,et al.Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase[J].Phytother Res,2023,37(10):4587-4606.
  72. 72.
    YANG Q J,WANG H,XU S Y,et al.Shenqi Tiaoshen Formula alleviates airway inflammation in rats with chronic obstructive pulmonary disease and kidney qi deficiency syndrome by inhibiting ferroptosis via regulating the Nrf2/SLC7A11/GPX4 signaling pathway[J].J South Med Univ,2024,44(10):1937-1946.
  73. 73.
    XIE J H,LIU M X,GAO Y T,et al.Integration of metabolomics and network pharmacology to reveal the protective mechanism underlying Qibai Pingfei capsule on chronic obstructive pulmonary disease[J].Front Pharmacol,2023,14:1258138.
  74. 74.
    ZOU J Y,WANG T J,ZANG N Z,et al.Pathogenesis of chronic obstructive pulmonary disease and modulating effect of traditional chinese medicine:A review[J].Chin J Exp Tradit Med Form,2025,31(1):287-298.
  75. 75.
    CHEN X,TSVETKOV A S,SHEN H M,et al.International consensus guidelines for the definition,detection,and interpretation of autophagy-dependent ferroptosis[J].Autophagy,2024,20(6):1213-1246.

قراءة النص الكامل

The above content is generated by Large Model Translation. The translated content is for reference only. We do not assume any commercial or legal responsibilty for any consequences arising from the use of our website