تقدم بحث الطب الصيني في التدخل في مسارات الاشارات المتعلقة بتضخم البروستات الحميد

  • role: First author第一作者
  • Affiliation:

    School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China

  • Email:2827033782@qq.com
  • Introduction:西E-mail2827033782@qq.com
LI Shenglong1,  
  • Affiliation:

    School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China

LU Ganggang1,  
  • Affiliation:

    School of Basic Medical Sciences,Gansu University of Chinese Medicine,Lanzhou 730000,China

LIANG Yonglin2,  
  • Affiliation:

    School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China

MA Xu1,  
  • Affiliation:

    Graduate School,Heilongjiang Academy of Chinese Medicine,Harbin 150006,China

GONG Meisheng3,  
  • Affiliation:

    School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China

LI Hui1,  
  • Affiliation:

    School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China

ZHAO Yuanbo1,  
  • Affiliation:

    School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China

TIAN Dacheng1,  
  • role: Corresponding author通信作者
  • Affiliation:

    Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China

  • Email:1114221808@qq.com
  • Introduction:尿E-mail1114221808@qq.com
ZHAO Yongqiang4*,  
  • role: Corresponding author通信作者
  • Affiliation:

    Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China

  • Email:lixixiang929@163.com
  • Introduction:E-maillixixiang929@163.com
LI Xixiang4*

ملخص

تضخم البروستات الحميد (BPH) هو مرض مزمن ومتقدم شائع لدى الرجال في الوسط وكبار السن، حيث يتمثل في تضخم البروستات وانسداد مخرج المثانة، مما يؤدي إلى أعراض مثل التبول المتكرر والرغبة الشديدة في التبول وصعوبة التبول. تتضمن ميزانية الإصابة بـ BPH عامل الزيادة في العمر واضطرابات استقلاب الهرمونات الجنسية والاستجابة الالتهابية وعدم التوازن بين انقسام الخلايا ونخسارتها. حاليا، تتضمن الأساليب العلاجية الرئيسية لـ BPH العلاج الدوائي والعلاج الفيزيائي والجراحة، إلا أن العلاج الدوائي قد يؤدي إلى اضطرابات الوظيفة الجنسية وانخفاض ضغط الدم وتأثيرات جانبية أخرى، وفعالية العلاج الفيزيائي محدودة، وتحمل الجراحة مخاطر ومضاعفات بعد العملية. لذلك، يجب بحاجة ماسة إلى البحث عن خيارات علاجية أكثر أمانًا وفعالية. تتميز الطب الصيني بميزتها في التشخيص والعلاج على أساس التمييز بين الأعراض والرؤية الشاملة، وتظهر مزايا العلاج من خلال مسارات متعددة وآليات متعددة. وقد أظهرت الأبحاث في السنوات الأخيرة أن الطب الصيني يمكنه من خلال تنظيم مسارات الإشارة مثل فوسفوينوزيتيد 3-أوكسيداز كيناز/بروتين كيناز بي (PI3K/Akt) وعامل التحويل-β (TGF-β)/سماد وعامل محفز-1ε المرتبط بعامل 2/عنصر تفاعل مضاد للأكسدة (Nrf2/ARE) ومستقبل الهرمون الذكري (AR) وعامل محفز نمو الأوعية الدموية-1α/فايسينيدو ذات البنية الأساسية (HIF-1α/VEGF)، والقضاء على التوتر التأكسدي والاستجابة الالتهابية وتقليل انقسام خلايا البروستات، وتعزيز خسارتها، لتحقيق تأثير علاجي. من خلال تلخيص وتحليل أدوار المسارات المذكورة أعلاه في نشوئ BPH وآلية التدخل الطبي في الطب الصيني، يتوقع أن يقدم هذا المقال بعض الأسس العلمية لعلاج BPH السريري وتطوير الأدوية.

مفهوم

تضخم البروستات الحميد؛ الطب الصيني؛ مسارات الاشارات؛ تقدم البحث

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