التقدم في دراسة آلية عمل أستركالوسيد في تنظيم مسار الجزيئات PI3K/Akt في الوقاية والعلاج من مضاعفات مرض السكري

  • role: First author第一作者
  • Affiliation:

    Anhui University of Chinese Medicine,Hefei 230012,China

  • Email:hkx835031518@163.com
  • Introduction:胡可心,在读硕士,住院医师,从事中医药防治内分泌疾病研究,E-mail:hkx835031518@163.com
HU Kexin1,  
  • Affiliation:

    Anhui University of Chinese Medicine,Hefei 230012,China

ZHU Jinru1,  
  • Affiliation:

    Anhui University of Chinese Medicine,Hefei 230012,China

WU Qing1,  
  • Affiliation:

    Anhui University of Chinese Medicine,Hefei 230012,China

WANG Shengmao1,  
  • Affiliation:

    Anhui University of Chinese Medicine,Hefei 230012,China

WANG Mengfan1,  
  • Affiliation:

    Anhui University of Chinese Medicine,Hefei 230012,China

QIAN Ai1,  
  • role: Corresponding author通信作者
  • Affiliation:

    The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China

    Key Laboratory of Xin'an Medical Education Department,Anhui University of Chinese Medicine, Hefei 230038,China

  • Email:fangzhaohui1111@163.com
  • Introduction:方朝晖,博士,教授,主任医师,博士生导师,从事中医药防治内分泌疾病研究,E-mail:fangzhaohui1111@163.com
FANG Zhaohui23*

ملخص

داء السكري (DM) هو مرض استقلابي ناتج عن نقص مطلق أو نسبي في إفراز الإنسولين وانخفاض حساسية الخلايا المحيطية للإنسولين، وقد أثر بشكل كبير على صحة البشرية جمعاء. المضاعفات المزمنة التي يسببها في مراحله المتأخرة يمكن أن تؤدي إلى تدهور أو فقدان وظائف عدة أعضاء مثل العين والقلب والكبد والكلى والأعصاب والأقدام، وهي السبب الرئيس لوفيات مرضى السكري. حققت الطب الحديث بعض التقدم في علاج المضاعفات، لكنه لا يزال يواجه مشاكل مثل ارتفاع التكلفة والآثار الجانبية الكبيرة للأدوية، لذا فإن البحث عن أدوية منخفضة التكلفة وفعالة هو أولوية حالياً. الأستراغالوس هو جوهرة باهرة في كنز الطب الصيني التقليدي، وأظهرت العديد من الدراسات أن مركبه الرئيسي أستركالوسيد يمتلك خصائص مضادة للالتهابات، مضادة للأكسدة، مضادة للفيروسات، ويحسن وظائف القلب والدماغ، ويحسن التوصيل العصبي ويقي عضلة القلب. في نفس الوقت، مسار إشارة فسفاتيديلينوسيتول 3-كينا / بروتين كيناز ب (PI3K/Akt) هو مسار إشارة مهم ينظم آليات متعددة مثل الإجهاد التأكسدي، الاستجابة الالتهابية، موت الخلايا المبرمج والالتهام الذاتي. أظهرت العديد من التجارب أهميته الكبيرة في مضاعفات السكري المختلفة، وشهدت الأبحاث تعاوناً واسعاً بين الاثنين. يستعرض هذا المقال الدراسات التي تبين كيف يساهم أستركالوسيد في تقليل سمية خلايا البنكرياس لدى مرضى السكري عن طريق تنظيم مسار PI3K/Akt، وحماية الوظائف الأساسية للقلب، وكبح تلف خلايا الشبكية، وتحسين خلل وظائف الأعصاب في الدماغ، وتقليل الأضرار المزمنة في الكلى والكبد، وتخفيف الضرر السمي في أعصاب وأوعية الأطراف السفلية، مما يوفر مرجعاً لتطبيق الأستراغالوس ومركبه الأحادي أستركالوسيد في العلاج السريري للسكري ومضاعفاته.

مفهوم

أستركالوسيد; مسار إشارة فسفاتيديلينوسيتول 3-كينا / بروتين كيناز ب (PI3K/Akt); مضاعفات مرض السكري; تقدم الأبحاث الدوائية

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