الدراسة التقدمية للعلاج الطبي الصيني التقليدي لسرطان خلايا الكبد المستند إلى مسار إشارات NF-κB

  • role: First author第一作者
  • Affiliation:

    Henan University of Chinese Medicine,Zhengzhou 450046,China

  • Email:1350355659@qq.com
  • Introduction:杨韧,在读硕士,从事中医药防治肝胆脾胃病的研究,E-mail:1350355659@qq.com
YANG Ren1,  
  • Affiliation:

    Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China

LI Mengge2,  
  • Affiliation:

    Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China

DANG Zhibo2,  
  • Affiliation:

    Henan University of Chinese Medicine,Zhengzhou 450046,China

GUO Biaobiao1,  
  • Affiliation:

    Henan University of Chinese Medicine,Zhengzhou 450046,China

LIU Shilong1,  
  • role: Corresponding author通信作者
  • Affiliation:

    Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China

  • Email:dzhqn@126.com
  • Introduction:党中勤,主任医师,博士生导师,从事中西医结合治疗肝胆脾胃疾病的研究,E-mail:dzhqn@126.com
DANG Zhongqin2*

ملخص

يسود سرطان خلايا الكبد (HCC) كنوع رئيسي من سرطان الكبد الأولي، ويحتل معدلات عالية في الإصابة والوفيات بين الأورام الخبيثة في بلدنا. في المراحل المبكرة، قد تكون الأعراض غير واضحة، وتنبؤ الحالة السريرية ضعيف، مما يؤدي إلى انخفاض معدل بقاء المرضى على قيد الحياة، وهو مرض يشكل تهديدًا بالغًا للصحة العامة. يرتبط حدوثه بعدوى فيروس التهاب الكبد، وشرب الكحول، والسمنة، والأضرار الدوائية، واضطراب المناعة، وغيرها من العوامل المتعددة التي قد تتكامل للتسبب في المرض. تشمل العلاجات الحديثة لسرطان الكبد استئصال الجراحة، وزراعة الكبد، والاستئصال بالترددات الراديوية، والعلاج الإشعاعي والكيميائي، لكنها جميعًا ذات حدود معينة مثل وجود آثار جانبية كبيرة وتنبؤ بحالة متدنية، مما يسبب عبء نفسي واقتصادي كبير على المرضى. العلاج الطبي الصيني التقليدي له تاريخ طويل في علاج سرطان الكبد، وله مزايا مثل استهداف متعدد، مستويات علاج متعددة، آثار جانبية قليلة، ومعدل انتكاس منخفض، ولا يقتصر على تعزيز فعالية العلاج بل يقلل أيضًا من الآثار الجانبية بعد العلاج الإشعاعي والكيميائي والجراحة، لذلك يحظى باهتمام واسع. أظهرت العديد من الدراسات أن العلاج الطبي الصيني التقليدي له تأثيرات مضادة للأورام، ومضادة للالتهابات، ومضادة للأكسدة، وقد يرتبط آليته بتنظيم مسار إشارات العامل النووي-κB (NF-κB)، مما يؤثر على مراحل متعددة في حدوث سرطان الكبد مثل تكاثر الخلايا، الغزو، الانتقال، والموت الخلوي المبرمج. أصبح دور مسار إشارات NF-κB في علاج سرطان الكبد بالطب الصيني التقليدي أحد الاتجاهات البحثية المهمة في وقتنا الحالي. بناءً على أساس البحث الحالي، تم استخدام منهج مراجعة منهجية للأدبيات لاسترجاع وتحليل الأدبيات الصينية والإنجليزية الحديثة ذات الصلة. من خلال دمج الآليات الجزيئية لتنظيم مسار إشارات NF-κB ودوره الأساسي في تطور سرطان الكبد، يمكن دراسة التقدم البحثي الحديث لتدخل الطب الصيني في هذا المسار لعلاج سرطان الكبد بعمق، مما يساعد على توفير أساس نظري جديد وفكرة تطبيق سريري للوقاية والعلاج بالطب الصيني التقليدي.

مفهوم

العامل النووي-κB (NF-κB); مسار الإشارة; سرطان خلايا الكبد; الطب الصيني التقليدي; التقدم البحثي

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