سابِق|تال

تقدم البحث في علاج سرطان المريء باستخدام الطب الصيني التقليدي بناءً على مسار إشارة PI3K/Akt

  • role： First author第一作者
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

  • Email：507389736@qq.com
  • Introduction：郭伟，在读硕士，从事中西医结合防治恶性肿瘤疾病研究，E-mail：507389736@qq.com
GUO Wei12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

PENG Chen12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

WANG Yikun12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

YU Zixuan12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

LIU Jintao12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

DING Jing12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

LI Yijing12,  
  • role： Corresponding author通信作者
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

  • Email：447334004@qq.com
  • Introduction：孙宏新，博士，主任医师，从事中西医结合防治恶性肿瘤疾病研究，E-mail：447334004@qq.com
SUN Hongxin1*

ملخص

سرطان المريء (EC) هو نوع شائع من الأورام الخبيثة في بلادنا، ومسار الإشارة فسفاتيديلينوسيتول 3-كيناز (PI3K)/بروتين كيناز B (Akt) كأحد المسارات الرئيسية المسببة للسرطان، يمكنه تعزيز تقدم دورة الخلية، التكاثر، الهجرة والاقتحام لخلايا EC، وتحفيز مقاومة الخلايا للعلاج الإشعاعي والكيميائي وقمع موت الخلايا المبرمج والالتهام الذاتي. الطب الصيني التقليدي، بفضل تعدد أهدافه ومكوناته، يمكنه استهداف مسار الإشارة PI3K/Akt لعلاج EC. تستكشف هذه الورقة الميكانيزمات الجزيئية ودور مسار PI3K/Akt في EC، وتوضح بالتفصيل الأهداف الفعالة والعلاجية للأدوية الصينية التي تدخل في علاج EC عبر التدخل في هذا المسار خلال السنوات الخمس الأخيرة. تشمل الأدوية الصينية التي تثبط مسار PI3K/Akt في EC الأعشاب المفردة والمستخلصات مثل الأبسفون الطبيعي، مسحوق أبواغ عشبة الريشي المنزوعة الجدران، مستخلصات ساق الأفعى الجنوبية، مستخلص جذر الهندباء، ومحلول بذور الزيت. المكونات الفعالة تشمل الفلافونويدات، التربين، السابونينات، الفينولات، السكريات، القلويات ومركبات أخرى. التركيبات العشبية تشمل تشي جيه سان، هو تشي سان، شوان فو داي شيه تانغ، تونغ يو تانغ ومشتقاتها، ليو جون زي تانغ وفورمولات السيليكون والجينسنغ، بالإضافة إلى مستحضرات حقن مركبة من الأعشاب مثل مشتقات عشبة القلقاس والمستخلصات الآمنية. تستعرض هذه الورقة الميكانيزمات وتأثيرات التدخل الصيني التقليدي في مسار PI3K/Akt بهدف تقديم مرجع لبحث وتطبيق أدوية جديدة لعلاج EC.

مفهوم

فسفاتيديلينوسيتول 3-كيناز (PI3K)/بروتين كيناز B (Akt);سرطان المريء;الطب الصيني التقليدي;تقدم البحث

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