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Forschungsfortschritte zu den molekularen Mechanismen der aktiven Bestandteile von Danshen gegen kolorektales Karzinom

  • role： First author第一作者
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

  • Email：15957478520@163.com
  • Introduction：郭嘉宁，在读硕士，从事中医基础理论和中医药抗肿瘤研究，E-mail： 15957478520@163.com
GUO Jianing12,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

NI Xiaochen12,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

ZHANG Kaiyuan12,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

FAN Wei12,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

WANG Chuhang12,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Cancer Hospital， Hangzhou 310022，China

XU Chao13,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

    Traditional Chinese Medicine ''Preventing Disease'' Wisdom Health Project Research Center of Zhejiang， Hangzhou 310053，China

HUANG Jianbo124,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

    Traditional Chinese Medicine ''Preventing Disease'' Wisdom Health Project Research Center of Zhejiang， Hangzhou 310053，China

JIANG Tao124,  
  • role： Corresponding author通信作者
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

    Traditional Chinese Medicine ''Preventing Disease'' Wisdom Health Project Research Center of Zhejiang， Hangzhou 310053，China

  • Email：zgjtcm@zcmu.edu.cn
  • Introduction：张光霁，博士，主任医师，教授，从事中医基础理论和中医药抗肿瘤研究，E-mail： zgjtcm@zcmu.edu.cn
ZHANG Guangji124*

Resümee

Kolorektales Karzinom (CRC) ist eine der häufigsten Krebsarten mit einer hohen Inzidenz unter verschiedenen Krebsarten und die zweithäufigste Todesursache bei Krebspatienten weltweit. CRC zeigt in frühen Stadien keine spezifischen Symptome, die meisten Patienten werden erst im mittleren oder späten Stadium diagnostiziert, was CRC zu einem aktuellen Forschungsschwerpunkt im Bereich der Tumoren des Verdauungssystems macht. Derzeit ist die chirurgische Behandlung von CRC mit hohen Risiken verbunden, häufig treten Metastasen, Rezidive, Medikamentenresistenzen sowie erhebliche Nebenwirkungen von Chemo- und Strahlentherapie auf. Mit der Entwicklung und Anwendung der Traditionellen Chinesischen Medizin wurde entdeckt, dass chinesische Arzneimittel und deren aktive Bestandteile die Proliferation, Invasion, Migration und Angiogenese von CRC-Zellen effektiv durch multipolare, mehrstufige und multifunktionale Mechanismen hemmen, außerdem Apoptose und Autophagie der CRC-Zellen fördern und somit das Fortschreiten von CRC verlangsamen, was ein aktueller Forschungsschwerpunkt in der CRC-Behandlung ist. Salvia miltiorrhiza (Danshen) besitzt Wirkungen wie die Aktivierung der Blutzirkulation, Beseitigung von Stasen, Freimachung der Meridiane und Schmerzlinderung, Kühlung des Blutes und Abbau von Abszessen, sie enthält viele chemische Bestandteile einschließlich Diterpenoide, Phenolsäuren, Flavonoide, Polysaccharide sowie stickstoffhaltige Verbindungen, Steroide und Laktone. Dieser Artikel gibt einen Überblick über die molekularen Mechanismen der aktiven Bestandteile von Danshen gegen CRC, die ihre anti-CRC-Wirkung durch verschiedene molekulare Mechanismen ausüben, einschließlich Blockierung des Zellzyklus von CRC, Förderung der Apoptose, Hemmung der Invasion und Migration von Zellen, Induktion der Autophagie, Unterdrückung der Tumorangio­genese und Umgestaltung des Tumormikromilieus, mit dem Ziel, neue Ansätze für die Medikamentenentwicklung und klinische Praxis bei der Behandlung von CRC mit Danshen zu bieten.

Schlüsselwort

Danshen;aktive Bestandteile;kolorektales Karzinom;molekulare Mechanismen;Forschungsfortschritte

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