Früher|Nächster

Forschungsfortschritte zu den aktiven Komponenten von Chuanxiong und zugehörigen Präparaten in der Prävention und Behandlung der Atherosklerose

  • role： First author第一作者
  • Affiliation：

    Graduate School of Liaoning University of Traditional Chinese Medicine （TCM）， Shenyang 110847， China

  • Email：3060502366@qq.com
  • Introduction：宋丽佳，在读博士，从事中西医结合防治心血管疾病研究，E-mail：3060502366@qq.com
SONG Lijia1,  
  • Affiliation：

    Affiliated Hospital of Liaoning University of TCM， Shenyang 110032， China

WANG Shuai2,  
  • Affiliation：

    Graduate School of Liaoning University of Traditional Chinese Medicine （TCM）， Shenyang 110847， China

LU Wenrui1,  
  • Affiliation：

    Graduate School of Liaoning University of Traditional Chinese Medicine （TCM）， Shenyang 110847， China

XIA Yunfeng1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Affiliated Hospital of Liaoning University of TCM， Shenyang 110032， China

  • Email：wfr925@qq.com
  • Introduction：王凤荣，博士，主任医师，教授，从事中西医结合防治动脉粥样硬化研究，E-mail：wfr925@qq.com
WANG Fengrong2*

Resümee

Atherosklerose (AS) ist eine Gefäßerkrankung, die hauptsächlich große und mittlere Arterien betrifft und die pathologische Grundlage vieler kardiovaskulärer Erkrankungen darstellt, wobei sie weltweit eine hohe Komplikationsrate und Sterblichkeit verursacht. Die traditionelle chinesische Medizin spielt eine wichtige Rolle bei der Prävention und Behandlung von AS und zeigt durch multiplen Zielstrukturen und multiple Wege einzigartige therapeutische Vorteile. Chuanxiong, als in der Klinik häufig verwendetes chinesisches Arzneimittel, enthält wichtige aktive anti-AS-Komponenten wie Ligustrazin, Chuanxiong-Lacton, Gaoben-Lacton, Quercetin, Ferulasäure, Vanillinsäure, Chlorogensäure, Gallussäure, Katecholsäure, Kaffeesäure, Resveratrol, β-Sitosterol usw. Diese Studie wertet die jüngste Literatur aus und stellt fest, dass die aktiven Komponenten von Chuanxiong AS durch Verbesserung der Endothelzellfunktion, Korrektur von Fettstoffwechselstörungen, Hemmung der Makrophagen-Schaumzellbildung, Hemmung der Invasion, Proliferation und Migration glatter Muskelzellen, Hemmung der Apoptose, Antikoagulation und Hemmung der Thrombozytenaktivierung, Schutz der Mitochondrienfunktion sowie Regulation des Darmmikrobioms und seiner Metaboliten modulieren können, und dabei signifikante pharmakologische Aktivität und klinisches Potenzial zeigen; klinisch wird Chuanxiong häufig mit Danshen, Chishao, Danggui und Bingpian kombiniert, um die Wirksamkeit zu erhöhen und eine synergistische anti-AS-Wirkung zu erzielen. Komplexpräparate auf Chuanxiong-Basis sind vorwiegend blutaktivierend und zeigen eine deutliche Wirksamkeit bei unterschiedlichen AS-Typen. Der Artikel erläutert den aktuellen Forschungsstand zu den aktiven Komponenten, Arzneipaaren und komplexen Präparaten von Chuanxiong in der Prävention und Behandlung von AS, um eine Grundlage für weiterführende theoretische und klinische Studien zu AS und seinen Komplikationen zu schaffen.

Schlüsselwort

Atherosklerose;Anti-Atherosklerose-Mechanismen;Chuanxiong und aktive Komponenten;Chuanxiong-Arzneipaarungen;chinesische Komplexarzneimittel auf Chuanxiong-Basis

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