References
- 1.Chinese College of Cardiovascular Physicians.Chinese expert consensus on antithrombotic therapy of panvascular diseases (2024 edition)[J].Nat Med J China,2024,104(12):906-923.
- 2.YANG J,ZHANG Y M,GE J B .Panvascular disease prevention and control:From disease treatment to comprehensive management[J].Chin Video J Cardiol,2021,4(1):1-6.
- 3.YANG J,WANG K Q,HUO Y,et al.Scientific statement for the prevention and treatment of panvascular disease[J].Chin Circ J,2019,34(11):1041-1046.
- 4.XU S W,GE J B,WENG J P.Endothelial dysfunction and panvascular diseases[J].J Univ Sci Technol China,2021,51(8):577-585.
- 5.XU S W,ILYAS I,LITTLE P J,et al.Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond:From mechanism to pharmacotherapies[J].Pharmacol Rev,2021,73(3):924-967.
- 6.GAO H J,REN J Y,WANG R L,et al.Research progress on the role of endothelial cell injury and dysfunction in atherosclerosis[J].Chin Gen Pract,2025,28(21):2697-2704.
- 7.PAN Y S,JING J,CAI X L,et al.Prevalence and vascular distribution of multiterritorial atherosclerosis among community-dwelling adults in Southeast China[J].JAMA Netw Open,2022,5(6):e2218307.
- 8.GARLAND-BAIRD L,FRASER K.Conceptualization of the chronic care model:Implications for home care case manager practice[J].Home Healthc Now,2018,36(6):379-385.
- 9.VAINAUSKIENĖ V,VAITKIENĖ R.Enablers of patient knowledge empowerment for self-management of chronic disease:An integrative review[J].Int J Environ Res Public Health,2021,18(5):2247.
- 10.NUÑO R,COLEMAN K,BENGOA R,et al.Integrated care for chronic conditions:The contribution of the ICCC Framework[J].Health Policy,2012,105(1):55-64.
- 11.LI J,ZHANG H Y,YANG J.Implications of domestic and foreign typical chronic disease management models for rural chronic disease management in China[J].Chin Gen Pract,2022,25(16):1935-1941.
- 12.ZHU X,CHEN A Y.Enlightenment of foreign classical chronic disease management modes on the management of chronic diseases in China[J].Chin Gen Pract,2023,26(1):21-26.
- 13.YANG J,ZHANG Y M,GE J B.Screening and early detection of panvascular disease[J].Shanghai Med J,2022,45(5):293-297.
- 14.PHAM M H X,CHRISTENSEN D M,KRISTENSEN A T,et al.Association of overweight and obesity with coronary risk factors and the presence of multivessel disease in patients with obstructive coronary artery disease-a nationwide registry study[J].Int J Cardiol Cardiovasc Risk Prev,2024,22:200299.
- 15.GRANDHI G R,MIRBOLOUK M,DARDARI Z A,et al.Interplay of coronary artery calcium and risk factors for predicting CVD/CHD mortality:The CAC Consortium[J].JACC Cardiovasc Imaging,2020,13(5):1175-1186.
- 16.MITCHELL J D,FERGESTROM N,GAGE B F,et al.Impact of statins on cardiovascular outcomes following coronary artery calcium scoring[J].J Am Coll Cardiol,2018,72(25):3233-3242.
- 17.BAO X Y,FENG J,LAN M J,et al.A review of the scope of research on clinical biomarkers of pan-vascular diseases[J].Electrocardiol Circ,2023,42(6):596-600,604.
- 18.MAO Y Q,KANG D D,ZHANG B W,et al.Research progress of multidisciplinary team diagnosis and treatment model in China and abroad[J].Chin Hosp,2022,26(3):18-21.
- 19.PENG T T,JIANG Y,JIANG X Y,et al.Research on operation process and influencing factors of multi-disciplinary treatment based on group decision-making theory[J].Med Soc,2021,34(12):75-79.
- 20.YU J,DAI X X,HU L.Practice and experience of one-station service model of disease-based MDT[J].Chin Hosp Manage,2019,39(1):33-34.
- 21.BI Q.Multidisciplinary integrated management of panvascular diseases[J].Chin J Cerebrovasc Dis,2022,19(3):145-147.
- 22.WEI S L,ZHOU Y W,XU S W,et al.Risk factors of pan-vascular diseases and their interactions[J].Biomed Transform,2024,5(4):113-124.
- 23.SUZUKI Y,OZAWA T,KURATA T,et al.A molecular complex of Ca(v)1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation-transcription coupling[J].Proc Natl Acad Sci U S A,2022,119(16):e2117435119.
- 24.EDGAR L,AKBAR N,BRAITHWAITE A T,et al.Hyperglycemia induces trained immunity in macrophages and their precursors and promotes atherosclerosis[J].Circulation,2021,144(12):961-982.
- 25.BRANDTS J,RAY K K.Novel and future lipid-modulating therapies for the prevention of cardiovascular disease[J].Nat Rev Cardiol,2023,20(9):600-616.
- 26.YU W,LIU W D,XIE D,et al.High level of uric acid promotes atherosclerosis by targeting NRF2-mediated autophagy dysfunction and ferroptosis[J].Oxid Med Cell Longev,2022,2022:9304383.
- 27.CALIRI A W,TOMMASI S,BESARATINIA A.Relationships among smoking,oxidative stress,inflammation,macromolecular damage,and cancer[J].Mutat Res Rev Mutat Res,2021,787:108365.
- 28.RAMAN P,KHANAL S.Leptin in atherosclerosis:Focus on macrophages,endothelial and smooth muscle cells[J].Int J Mol Sci,2021,22(11):5446.
- 29.LANE M M,GAMAGE E,DU S T,et al.Ultra-processed food exposure and adverse health outcomes:Umbrella review of epidemiological Meta-analyses[J].Bmj,2024,384:e077310.
- 30.WU C L,GUO J X,YANG J L,et al.Effects of high-fat diet on rat aortic endothelial cell morphology and stiffness[J].Med Biomech,2020,35(4):449-454.
- 31.WEN J,SUN H,YANG B W,et al.Long-term polystyrene nanoplastic exposure disrupt hepatic lipid metabolism and cause atherosclerosis in ApoE-/- mice[J].J Hazard Mater,2024,466:133583.
- 32.DE BONT J,JAGANATHAN S,DAHLQUIST M,et al.Ambient air pollution and cardiovascular diseases:An umbrella review of systematic reviews and Meta-analyses[J].J Intern Med,2022,291(6):779-800.
- 33.WU Z N,CHEN T W,QIAN Y X,et al.High-dose ionizing radiation accelerates atherosclerotic plaque progression by regulating P38/NCOA4-mediated ferritinophagy/ferroptosis of endothelial cells[J].Int J Radiat Oncol Biol Phys,2023,117(1):223-236.
- 34.ZHANG X,ZHANG F,LI M L,et al.Application and challenges of intelligent robots in grassroots chronic disease management[J].Chin Gen Pract,2025,28(1):7-12,19.
- 35.XIAO J,LI M Y,CAI R W,et al.Smart pharmaceutical monitoring system with personalized medication schedules and self-management programs for patients with diabetes:Development and evaluation study[J].J Med Internet Res,2025,27:e56737.
- 36.PROCHASKA J O,DICLEMENTE C C.Transtheoretical therapy:Toward a more integrative model of change[J].Psychother Theory Res Pract,1982,19(3):276-288.
- 37.JIN G H,XU S M,ZHANG R,et al.A view of the construction of doctor-respected ethics from the cause analysis of conflicts between doctor and patient[J].Chin Med Ethics,2018,31(5):591-596.
- 38.LOMBARD J H.Depression,psychological stress,vascular dysfunction,and cardiovascular disease:Thinking outside the barrel [J].J Appl Physiol,2010,108(5):1025-1026.
- 39.ZHU Y Q,HADDAD Y,YUN H J,et al.Induced inflammatory and oxidative markers in cerebral microvasculature by mentally depressive stress [J].Mediators Inflamm,2023,2023:4206316.
- 40.KATON W,LIN E H B,KROENKE K.The association of depression and anxiety with medical symptom burden in patients with chronic medical illness [J].Gen Hosp Psychiatry,2007,29(2):147-155.
- 41.YUAN J,LIU Y,LIAO J W,et al.Clinical heterogeneity of post-stroke depression and post-coronary heart disease depression[J].Chin J Gerontol,2020,40(8):1765-1769.
- 42.MAISTO M,DIANA B,DI TELLA S,et al.Digital interventions for psychological comorbidities in chronic diseases-a systematic review[J].J Pers Med,2021,11(1):30.
- 43.HASKINS R,GARFINKEL I,MCLANAHAN S.Introduction:Two-generation mechanisms of child development[J].Future Child,2014,24(1):3-12.
- 44.LI H M,WU Y B,SUN J,et al.Family health and chronic disease control:The mediating role of health literacy,health behavior and trust in primary care services[J].Popul Dev,2023,29(5):145-160.
- 45.YAN J Q,MENG F L,CHEN Y S,et al.The relationship between perceived social support and medication adherence in patients[J].J Commun Med,2016,14(23):1-4.
- 46.GONG W Q,GUO Q,JIANG L.The effects of family communication patterns on middle-aged and elderly's coping behavior with epidemic diseases[J].J Zhejiang Univ:Human Soc Sci,2021,51(2):42-53.
- 47.WANG J Y,KONG X Q,WANG L,et al.Relationships among social support,self-efficacy,and frailty in disabled older adults and their family caregivers:The actor-partner interdependence analysis[J].Chin Nurs Manage,2024,24(12):1836-1841.
- 48.ZHANG Y,MEI D,XING F M,et al.The correlation between social support,coping styles and resilience among elderly people in the community[J].Chin J Gerontol,2024,44(7):1755-1758.
- 49.DELPINO F M,COSTA Â K,FARIAS S R,et al.Machine learning for predicting chronic diseases:A systematic review[J].Public Health,2022,205:14-25.
- 50.AFZAL N,SOHN S,ABRAM S,et al.Mining peripheral arterial disease cases from narrative clinical notes using natural language processing[J].J Vasc Surg,2017,65(6):1753-1761.
- 51.ROSS E G,SHAH N H,DALMAN R L,et al.The use of machine learning for the identification of peripheral artery disease and future mortality risk[J].J Vasc Surg,2016,64(5):1515-1522.
- 52.LIU Q,ZHANG M,HE Y F,et al.Predicting the risk of incident type 2 diabetes mellitus in Chinese elderly using machine learning techniques[J].J Pers Med,2022,12(6):905.
- 53.LI Q,CAMPAN A,REN A,et al.Automating and improving cardiovascular disease prediction using machine learning and EMR data features from a regional healthcare system[J].Int J Med Inf,2022,163:104786.
- 54.JOHRI A M,SINGH K V,MANTELLA L E,et al.Deep learning artificial intelligence framework for multiclass coronary artery disease prediction using combination of conventional risk factors,carotid ultrasound,and intraplaque neovascularization[J].Comput Biol Med,2022,150:106018.
- 55.JOSHI M,MELO D P,OUYANG D,et al.Current and future applications of artificial intelligence in cardiac CT[J].Curr Cardiol Rep,2023,25(3):109-117.
- 56.PAN C L,LIU L C,PAN D.Integration of CNN and Transformer for 3D coronary artery CT image segmentation[J].Electron Meas Technol,2025,48(6):143-151.
- 57.CAO Y H,LI C,YANG J J,et al.Application status of AI in diagnosis and treatment of cardiovascular diseases[J].Chin Bull Life Sci,2022,34(8):918-928.
- 58.AL'AREF S J,MALIAKAL G,SINGH G,et al.Machine learning of clinical variables and coronary artery calcium scoring for the prediction of obstructive coronary artery disease on coronary computed tomography angiography:Analysis from the CONFIRM registry[J].Eur Heart J,2020,41(3):359-367.
- 59.KOLOSSVÁRY M,PARK J,BANG J I,et al.Identification of invasive and radionuclide imaging markers of coronary plaque vulnerability using radiomic analysis of coronary computed tomography angiography[J].Eur Heart J Cardiovasc Imaging,2019,20(11):1250-1258.
- 60.YANG S,KOO B K,HOSHINO M,et al.CT angiographic and plaque predictors of functionally significant coronary disease and outcome using machine learning[J].JACC Cardiovasc Imag,2021,14(3):629-641.
- 61.SHI Z,ZHU C C,DEGNAN A J,et al.Identification of high-risk plaque features in intracranial atherosclerosis:Initial experience using a radiomic approach[J].Eur Radiol,2018,28(9):3912-3921.
- 62.SU J,ZHANG Y,KE Q Q,et al.Mobilizing artificial intelligence to cardiac telerehabilitation[J].Rev Cardiovasc Med,2022,23(2):45.
- 63.CAPPON G,VETTORETTI M,SPARACINO G,et al.Continuous glucose monitoring sensors for diabetes management:A review of technologies and applications[J].Diabetes Metab J,2019,43(4):383-397.
- 64.BEQUETTE B W.Continuous glucose monitoring:Real-time algorithms for calibration,filtering,and alarms[J].J Diabetes Sci Technol,2010,4(2):404-418.
- 65.VETTORETTI M,CAPPON G,FACCHINETTI A,et al.Advanced diabetes management using artificial intelligence and continuous glucose monitoring sensors[J].Sensors (Basel),2020,20(14):3870.
- 66.GEHI A K,ALI S,NA B,et al.Self-reported medication adherence and cardiovascular events in patients with stable coronary heart disease:The heart and soul study [J].Arch Intern Med,2007,167(16):1798-1803.
- 67.MARTANI A,GENEVIÈVE L D,POPPE C,et al.Digital pills:A scoping review of the empirical literature and analysis of the ethical aspects [J].BMC Med Ethics,2020,21(1):3.
- 68.CHEN T Y,ZHANG X L,JIANG H T,et al.Are you smoking? Automatic alert system helping people keep away from cigarettes[J].Smart Health,2018,9-10:158-169.
- 69.LI S,ZHANG L D,CHENG Y Y,et al.Discussion on rhythmical changes and treatment of blood pressure of hypertension from TCM time medicine[J].China J Tradit Chin Med Pharm,2020,35(6):3011-3014.
- 70.HUI X S.Mechanism of Panax notoginseng regulating miR-370-3p/IRAK2/NF-κB pathway to improve vascular endothelial function injury in hyperlipidemia[D].Beijing:China Academy of Chinese Medical Sciences,2022.
- 71.WANG J Y.The mechanism of Xueguan Kangshuai Formula via the regulation of miR-146a/TRAF6/NF-κB to improve vascular aging[D].Beijing:China Academy of Chinese Medical Sciences,2021.
- 72.CHEN H W,LI J,LIN F,et al.Effect of Xuanbi Antong formula in improving ventricular remodeling in myocardial infarction rats and its mechanism[J].Chin J Exp Tradit Med Form,2017,23(23):71-78.
- 73.WANG J,YAO K W,XING Y W,et al.Clinical research and practice on the combination of coronary heart disease symptoms and conditions[J].J Tradit Chin Med,2015,56(24):2089-2092,2097.
- 74.WANG J,YAO K W,LI J,et al.Researches on the theoretical innovation and clinical application of "phlegm-blood stasis-stagnation-deficiency" in coronary heart disease[J].Chin J Integr Med,2019,39(8):1015-1019.
- 75.WANG J,LI J S,YAO K W,et al.Research on quantified diagnosis and combining diseases with syndrome of blood stasis[J].J Chin Integr Med,2003,1(1):21-24.
- 76.LI H Z,WANG J,HE H Q,et al.Construction of diagnosis-treatment knowledge model of diseases and syndrome combination for coronary heart disease angina pectoris:Based on traditional Chinese medicine thinking[J].J Tradit Chin Med,2019,60(15):1288-1293.
- 77.HAN X X,ZHU H X,TANG Z S,et al.Research status and prospects of artificial intelligence in clinical application of traditional Chinese medicine[J].Chin J Tradit Chin Med Pharm,2025,40(4):1527-1531.
- 78.LI H Z,WANG J,GUO Y C,et al.Research on diagnosis and prescription system of coronary heart disease with syndrome elements based on improved Transformer algorithm[J].Chin J Exp Tradit Med Form,2023,29(1):148-154.
- 79.YANG B Y,YE X M,XIA S T,et al.Study on the development of dual referral system and the hierarchical medical system[J].Chin Health Stand Manage,2018,9(23):22-25.
- 80.CHEN J,HE X W,YAN Z J,et al.Study on influencing factors of doctors' two-way referral behavior in urban medical association:A case study of a hospital medical association in Beijing[J].Chin J Soc Med,2022,39(6):693-698.
- 81.LI J L,JIANG S H,CHEN W,et al.Discussion on the construction of emergency passageway and two-way referral platform[J].Chin Commun Doct,2024,40(22):148-150.


